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81.
Chen Qiumin Yu Guangchao Wang Xiangyu Meng Xiangnan Lv Chunmao 《Journal of Plant Growth Regulation》2021,40(1):147-153
Journal of Plant Growth Regulation - Powdery mildew (PM) is one of the most severe foliar diseases in cucumbers (Cucumis sativus L.), but the inheritance of PM resistance remains unclear. The... 相似文献
82.
Fang Yong E Cailing Wu Shixing Meng Zudong Qin Guifang Wang Rongying 《Cytotechnology》2021,73(6):775-785
Cytotechnology - Psoriasis is a skin disorder that is classed as an autoimmune disease. It is characterized by excessive proliferation, abnormal migration and differentiation of keratinocytes, as... 相似文献
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Duan S. B. Wei S. S. Wang H. M. Ding S. H. Chen Y. Z. Tian J. J. Wang Y. J. Chen W. Chen J. Meng Q. L. 《Molecular Biology》2021,55(6):884-888
Molecular Biology - When expressing streptavidin recombinant polypeptide on magnetosomes (called bacterial magnetic nanoparticles, or BMPs), the presence of endogenous bacterial biotin might be... 相似文献
85.
Zhang Changjie Jiang Xingyi Li Meng Liang Jinlian Liu Jianping Liang Wei 《Journal of Ethology》2021,39(3):393-398
Journal of Ethology - Imperfect Batesian mimicry is common in nature. Female common cuckoos (Cuculus canorus), for instance, seem to be imperfect mimics of hawks (Accipiter spp.) in both appearance... 相似文献
86.
Jinnan Wang Houjun Zhou Yanqiu Zhao Cheng Jiang Jihong Li Fang Tang Yingli Liu Shutang Zhao Jianjun Hu Xueqin Song Meng‐Zhu Lu 《植物学报(英文版)》2021,63(10):1683-1694
87.
Lin Zhu Xiaoyan Yang Juyi Li Xiong Jia Xiangli Bai Ying Zhao Wenzhuo Cheng Meng Shu Yan Zhu Si Jin 《遗传学报》2021,48(2):134-146
Gene therapy has become the most effective treatment for monogenic diseases. Congenital LEPTIN deficiency is a rare autosomal recessive monogenic obesity syndrome caused by mutations in the Leptin gene. Ob/ob mouse is a monogenic obesity model, which carries a homozygous point mutation of C to T in Exon 2 of the Leptin gene. Here, we attempted to edit the mutated Leptin gene in ob/ob mice preadipocytes and inguinal adipose tissues using CRISPR/Cas9 to correct the C to T mutation and restore the production of LEPTIN protein by adipocytes. The edited preadipocytes exhibit a correction of 5.5% of Leptin alleles and produce normal LEPTIN protein when differentiated into mature adipocytes. The ob/ob mice display correction of 1.67% of Leptin alleles, which is sufficient to restore the production and physiological functions of LEPTIN protein, such as suppressing appetite and alleviating insulin resistance. Our study suggests CRISPR/Cas9-mediated in situ genome editing as a feasible therapeutic strategy for human monogenic diseases, and paves the way for further research on efficient delivery system in potential future clinical application. 相似文献
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Hong Zhou Xu-dong Zheng Chang-ming Lin Jie Min Shuang Hu Ying Hu Liang-yun Li Jia-si Chen Yu-min Liu Hao-dong Li Xiao-ming Meng Jun Li Ya-ru Yang Tao Xu 《International journal of biological sciences》2021,17(2):651
Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from pre-mRNA back-splicing and comes in to play by adequate expression. The differential expression in prostate tissues compared with the control reveals the promising capacity in modulating processes including carcinogenesis and metastasis. However, the biological mechanisms of regulatory network in PC needs to systemically concluded. In this review, we enlightened the comprehensive studies on the definite mechanisms of circRNAs affecting tumor progression and metastasis. What''s more, we validated the potential clinical application of circRNAs serving as diagnostic and prognostic biomarker. The discussion and analysis in circRNAs will broaden our knowledge of the pathogenesis of PC and further optimize the current therapies against different condition. 相似文献