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71.
Enantiomeric 4‐Acylamino‐6‐alkyloxy‐2 Alkylthiopyrimidines As Potential A3 Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy 下载免费PDF全文
Daniela Rossi Rita Nasti Annamaria Marra Silvia Meneghini Giuseppe Mazzeo Giovanna Longhi Maurizio Memo Barbara Cosimelli Giovanni Greco Ettore Novellino Federico Da Settimo Claudia Martini Sabrina Taliani Sergio Abbate Simona Collina 《Chirality》2016,28(5):434-440
The chiral separation of enantiomeric couples of three potential A3 adenosine receptor antagonists: (R/S)‐N‐(6‐(1‐phenylethoxy)‐2‐(propylthio)pyrimidin‐4‐yl)acetamide ( 1 ), (R/S)‐N‐(2‐(1‐phenylethylthio)‐6‐propoxypyrimidin‐4‐yl)acetamide ( 2 ), and (R/S)‐N‐(2‐(benzylthio)‐6‐sec‐butoxypyrimidin‐4‐yl)acetamide ( 3 ) was achieved by high‐performance liquid chromatography (HPLC). Three types of chiroptical spectroscopies, namely, optical rotatory dispersion (ORD), electronic circular dichroism (ECD), and vibrational circular dichroism (VCD), were applied to enantiomeric compounds. Through comparison with Density Functional Theory (DFT) calculations, encompassing extensive conformational analysis, full assignment of the absolute configuration (AC) for the three sets of compounds was obtained. Chirality 28:434–440, 2016. © 2016 Wiley Periodicals, Inc. 相似文献
72.
73.
Impact of bariatric surgery on type 2 diabetes 总被引:4,自引:0,他引:4
Meneghini LF 《Cell biochemistry and biophysics》2007,48(2-3):97-102
The management and prevention of diabetes through lifestyle modifications and weight loss should be the mainstay of therapy
in appropriate candidates. Although the results from the Diabetes Prevention Trial and the Finnish Prevention Study support
this approach, over 95% of patients not participating in a prevention research study are unable to achieve and maintain any
significant weight loss over time. Bariatric surgery for weight loss is an emerging option for more sustainable weight loss
in the severely obese subject, especially when obesity is complicated by diabetes or other co-morbidities. The two most common
types of procedures currently used in the United States are adjustable gastric bands and Roux-en-Y gastric bypass. These procedures
can be performed laparoscopically, further reducing the perioperative morbidity and mortality associated with the surgery.
While the gastric bypass procedure usually results is greater sustained weight loss (40–50%) than adjustable gastric banding
(20–30%), it also carries greater morbidity and nutritional/metabolic issues, such as deficiencies in iron, B12, calcium,
and vitamin D. Following bariatric surgery most subjects experience improvements in diabetes control, hypertension, dyslipidemia,
and other obesity-related conditions. In patients with impaired glucose tolerance most studies report 99–100% prevention of
progression to diabetes, while in subjects with diabetes prior to surgery, resolution of the disease is reported in 64–93%
of the cases. While improvements in insulin resistance and beta-cell function are related to surgically induced weight loss,
the rapid post-operative improvement in glycemia is possibly due to a combination of decreased nutrient intake and changes
in gut hormones as a result of the bypassed intestine. Post-prandial hyperinsulinemic hypoglycemia associated with nesidioblastosis
has been described in a series of patients following gastric bypass surgery, and may be related to the described changes in
GLP-1 and other gut hormones. 相似文献
74.
Wanessa LF Tavares Gleidice E Lavalle Mariana S Figueiredo Aline G Souza Angelica C Bertagnolli Fernando AB Viana Paulo RO Paes Rubens A Carneiro Guilherme AO Cavalcanti Marilia M Melo Geovanni D Cassali 《Acta veterinaria Scandinavica》2010,52(1):1-6
Background
Hypertension and proteinuria are medical complications associated with the multisystemic effects of long-term hypercortisolism in dogs with hyperadrenocorticism (HAC).Methods
This study investigated the relationships among adrenocorticotropic hormone (ACTH)-stimulation test results, systemic blood pressure, and microalbuminuria in clinically-healthy dogs (n = 100), in dogs affected with naturally occurring pituitary-dependent (PDH; n = 40), or adrenal-dependent hyperadrenocorticism (ADH; n = 30).Results
Mean systemic blood pressure was similar between clinically healthy dogs and dogs with HAC (p = 0.803). However the incidence of hypertension was highest in dogs with ADH (p = 0.017), followed by dogs with PDH, with the lowest levels in clinically healthy dogs (p = 0.019). Presence of microalbuminuria and albuminuria in clinically healthy dogs and dogs affected with HAC was significantly different (p < 0.001); incidences of albuminuria followed the same pattern of hypertension; highest incidence in dogs with ADH, and lowest level in clinically healthy dogs; but microalbuminuria showed a different pattern: clinically healthy dogs had highest incidences and dogs with ADH had lowest incidence. The presence of albuminuria was not associated with blood pressure values, regardless of whether dogs were clinically healthy or affected with ADH or PDH (p = 0.306).Conclusions
Higher incidence of hypertension and albuminuria, not microalbuminuria was seen in dogs affected with HAC compared to clinically healthy dogs; incidence of hypertension and albuminuria was significantly higher in dogs affected with ADH compared to PDH. However, presence of albuminuria was not correlated with systemic blood pressure. 相似文献75.
Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species 总被引:6,自引:0,他引:6
Active oxygen species are suspected as being a cause of the cellular damage that occurs at the site of inflammation. Phagocytic cells accumulate at these sites and produce superoxide ion, hydrogen peroxide and hydroxyl radical. The ultimate killing species, the cellular target and the mechanism whereby the lethal injury is produced are unknown. We exposed mouse fibroblasts to xanthine oxidase and acetaldehyde, a system which mimics the membrane of phagocytic cells in terms of production of oxygen species. We observed that the generation of these species produced DNA strand breaks and cellular death. The metal chelator o-phenanthroline completely abolished the former effect, and at the same time it effectively protected the cells from lethal injuries. Because complexing iron o-phenanthroline prevents the formation of hydroxyl radical by the Fendon reaction (Fe(II) + H2O2----Fe(III) + OH- + OH.), it is proposed that most of the cell death and DNA damage are brought about by OH radical, produced from other species by iron-mediated reactions. 相似文献
76.
V79 Chinese-hamster cells rendered resistant to high cadmium concentration also become resistant to oxidative stress. 总被引:3,自引:0,他引:3 下载免费PDF全文
Chinese hamster cells (V79) resistant to high concentrations of Cd2+ in the medium were obtained by using the procedure of Beach & Palmiter [(1981) Proc. Natl. Acad. Sci. U.S.A. 78, 2110-2114], which in mouse led to amplification of metallothionein (MT) genes and to an enrichment in cellular MT. The Cd-resistant V79 clones isolated were significantly more resistant than parental cells to oxidative stress by extracellular H2O2 or a mixture of H2O2 and superoxide anion (O2-) generated by xanthine oxidase plus acetaldehyde. On a per-cell basis, there was no difference between the two cells in their total H2O2-decomposing or O2-(-)dismutating activity. The most likely explanation is that an enrichment in MT content in the Cd-resistant cells was responsible for this effect, because of the antioxidant properties already described for this protein. 相似文献
77.
Marcelo Calderaro Elizabeth A. L. Martins Rogerio Meneghini 《Molecular and cellular biochemistry》1993,126(1):17-23
Menadione produces DNA strand breaks (DNA sb) in cultured Chinese hamster fibroblasts which are, to a great extent, mediated by OH radical. A reasonable hypothesis is that H2O2, a product of menadione metabolism, reacts with nuclear iron and produces OH radicalin situ. Consistent with that, 1,10-phenanthroline (PHEN) prevents menadione-induced DNA sb at low (<200 M) concentrations of the chelator. However, at higher PHEN concentrations, the effect is reversed and an enhancement of DNA sb is observed. The PHEN-induced enhancement of DNA sb becomes more evident at high (>60 M) menadione concentrations and is strongly prevented by neocuproine (NEO), an efficient copper chelator. However, NEO offers only a slight protection against DNA sb caused by menadione alone. The results are consistent with the following events: (i) the products of menadione metabolism causes copper ion release from some cellular compartment; (ii) in the presence of PHEN, a Cu(PHEN)2 complex is formed; (iii) the Cu(PHEN)2 complex is known to be very clastogenic, inducing DNA damage in a reducing environment.Evidence is also presented that menadione metabolism causes an increase in intracellular chelatable iron: in the presence of a constant 2,2-dipyridyl concentration, the DNA sb produced by increasing concentrations of menadione become progressively less susceptible to inhibition by the chelator.Therefore the DNA damage originated from menadione metabolism seems to be caused by two conjugated and synergistic events, viz., the production of reactive oxygen species and the release of copper and iron from a cellular storage site into a free form pool, capable of catalyzing DNA damaging reactions.Abbreviations sb
strand breaks
- PHEN
1,10-phenanthroline
- PBS
phosphate-buffered saline (8.1 mM Na2HPO4, 1.47 mM KH2PO4, 1.68 mM KCl, 137 mM NaCl, pH 7.0)
- HP
Hydrogen Peroxide
- Md
Menadione
- NEO
Neocuproine 相似文献
78.
An increase in bioavailable tin in the environment could result in bioaccumulation thereof in agricultural crops, and therefore, have adverse health consequences on humans that eat these crops. The aims of the current study were thus to assess the uptake of Sn by spinach plants, and the subsequent effects this will have on the uptake of Na, Zn, K, Ca, and Mg as well as the growth of spinach plants. Spinach plants were grown in sand culture and received tin at concentrations of 0.02, 0.2, 2 and 20 mg/L along with a nutrient solution. The uptake of tin at detectible concentrations only occurred at the highest concentrations (2 and 20 mg/L), and it was mostly retained in the roots of the plants. Tin additions also resulted in no visual toxicity symptoms, and might be beneficial to biomass production. Further field trials are needed to ensure that these experimental results remain true under field conditions. 相似文献
79.
80.