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991.
992.
Ana Luiza Tardem Maciel Thayana da Conceio Barbosa Caroline Barbieri Blunck Karolyne Wolch Amanda de Albuquerque Lopes Machado Elaine Sobral da Costa Lavínia Lustosa Bergier Mrcia Trindade Schramm Maura Rosane Valrio Ikoma-Coltutato Mecneide Mendes Lins Thais Ferraz Aguiar Marcela Braga Mansur Mariana Emerenciano 《Translational oncology》2022,15(1)
Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell precursor acute lymphoblastic leukaemia (B-ALL). In ∼50% of these cases, the mechanisms underlying this dysregulation are unknown. IKAROS Family Zinc Finger 1 (IKZF1) is a possible candidate to play a role in this dysregulation since it binds to the CRLF2 promoter region and suppresses its expression. We hypothesised that IKZF1 loss of function, caused by deletions or its short isoforms expression, could be associated with CRLF2 overexpression in B-ALL. A total of 131 paediatric and adult patients and 7 B-ALL cell lines were analysed to investigate the presence of IKZF1 deletions and its splicing isoforms expression levels, the presence of CRLF2 rearrangements or mutations, CRLF2 expression and JAK2 mutations. Overall survival analyses were performed according to the CRLF2 and IKZF1 subgroups. Our analyses showed that 25.2% of patients exhibited CRLF2 overexpression (CRLF2-high). CRLF2-high was associated with the presence of IKZF1 deletions (IKZF1del, p = 0.001), particularly with those resulting in dominant-negative isoforms (p = 0.006). Moreover, CRLF2 expression was higher in paediatric samples with high loads of the short isoform IK4 (p = 0.011). It was also associated with the occurrence of the IKZF1 plus subgroup (p = 0.004). Furthermore, patients with CRLF2-high/IKZF1del had a poorer prognosis in the RELLA05 protocol (p = 0.067, 36.1 months, 95%CI 0.0-85.9) and adult cohort (p = 0.094, 29.7 months, 95%CI 11.8–47.5). In this study, we show that IKZF1 status is associated with CRLF2-high and dismal outcomes in B-ALL patients regardless of age. 相似文献
993.
994.
Crypthecodinium cohnii with emphasis on DHA production: a review 总被引:3,自引:0,他引:3
Ana Mendes Alberto Reis Rita Vasconcelos Pedro Guerra Teresa Lopes da Silva 《Journal of applied phycology》2009,21(2):199-214
Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid (PUFA) that belongs to the ω-3 group. In recent years, DHA has
attracted much attention because of its recognized beneficial effect on human health. At present, fish oil is the major source
of DHA, but it may be produced by microorganisms with additional benefits. Marine microorganisms may contain large amounts
of DHA and are considered a potential source of this important fatty acid. Some of these organisms can be grown heterotrophically
on organic substrates without light, offering the possibility of greatly increasing microalgal cell concentration under controlled
and monitored conditions, resulting in a very high quality product. Among the heterotrophic marine dinoflagellates, Crypthecodinium cohnii has been identified as a prolific producer of DHA. The organism is extraordinary in that it produces no other PUFAs than
DHA in its cell lipid in any significant amount, which makes the DHA purification process very attractive, particularly for
pharmaceutical and nutraceutical applications. This paper reviews recent advances in the biotechnological production of DHA
by C. cohnii. 相似文献
995.
Emygdio Ana Paula Mendes Degobbi Cristiane Carotenuto Federico Castro e Silva Dulcilena de Matos Quintino Thaysla Beluco Zanetti Rafael Henrique de Souza Mantoani Mauricio C. Boschilia Solana Meneghel Guerra Lara Chaves Carvalho da Silva Dias Pedro Leite Morris Cindy E. Gonalves Fbio Luiz Teixeira 《Aerobiologia》2022,38(1):85-101
Aerobiologia - Primary biological aerosol particles (PBAPs) are involved in multiple phenomena ranging from seasonal allergies to pandemic diseases. Furthermore, PBAPs that act as ice nuclei, might... 相似文献
996.
de Menezes Luiz Henrique Sales do Esprito Santo Eliezer Luz dos Santos Marta Maria Oliveira de Carvalho Tavares Iasnaia Maria Mendes Adriano Aguiar Franco Marcelo de Oliveira Julieta Rangel 《Biotechnology letters》2022,44(1):89-99
Biotechnology Letters - To immobilize Candida rugosa lipase in Accurel MP 1000 (CRL-AMP) by physical adsorption in organic medium and apply in the synthesis of wax esters dodecanoyl octadecanoate 1... 相似文献
997.
de Oliveira Carvalho Andra da Consolao Kerr Rodrigo Tavano Virginia Maria Mendes Carlos Rafael B. 《Biogeochemistry》2022,159(2):139-158
Biogeochemistry - The structure of the phytoplankton community is strongly influenced by environmental variables linked with variations in sea–air CO2 net fluxes (FCO2). However, compared to... 相似文献
998.
A new species of spore, Costatoperforosporites friisiae sp. nov., is described from the Early Cretaceous (late Aptian–early Albian) deposits of Catefica in the Lusitanian Basin, western Portugal. Although the morphology of the muri is clearly of the Cicatricosisporites type, the presence of micropores on these sculptural elements and within the intervening grooves is a particularly distinctive feature and more typical of spores that have been attributed previously to Costatoperforosporites. As a result, this genus is emended not only to accommodate Costatoperforosporites friisiae but also to differentiate it more clearly from other, similar, murornate genera. It is considered to represent the family Anemiaceae. So far, Costatoperforosporites friisiae has only been encountered in the Catefica palynoflora. The presence of many other pteridophyte spores, especially of schizaealean derivation, together with abundant cheirolepidiacean remains at this locality, strongly suggests a warm, moist climate and diverse source vegetation. 相似文献
999.
1000.
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA 下载免费PDF全文
Alexandre Dalet Philippe Pierre Alexandre Dalet Rafael J Argüello Alexis Combes Lionel Spinelli Sebastien Jaeger Mathieu Fallet Thien-Phong Vu Manh Andreia Mendes Jessica Perego Marisa Reverendo Voahirana Camosseto Marc Dalod Tobias Weil Manuel A Santos Evelina Gatti Philippe Pierre 《The EMBO journal》2017,36(6):761-782