Toxic epidermal necrolysis associated with radiotherapy and phenytoin in a patient with non-Hodking's lymphoma: A case report

Toxic epidermal necrolysis (TEN) is a disease which is characterized by fever and desquamation of the skin and mucosal membranes. It is usually related with drugs, especially aromatic anticonvulsants which are recognized as the most common cause of this disorder. Cranial irradiation may act as a precipitating factor along with anticonvulsants for the development of TEN. We report a 28-year-old patient with central nervous system (CNS) relapsed non-Hodgkin lymphoma (NHL) who developed TEN after cranial radiotherapy and concurrent phenytoin treatment.     

Is the lateral angle of the internal acoustic canal sexually dimorphic in non-adults? An investigation by routine cranial magnetic resonance imaging

The lateral angle of the internal acoustic canal is one of the measurements of petrous bone that has been previously studied for sex estimation, mostly in adults. We aimed at evaluating the effects of age, side, and sex on the lateral angle of the internal acoustic canal in pediatric patients.Pediatric routine cranial MRI studies were retrospectively investigated for this study. The lateral angle was measured on T2-weighted axial images when the anterior and posterior lips of the meatus and the cochlea were clearly visible on the same image. The data were evaluated for age, side and sex-related changes. Although 552 temporal bones from 273 patients were inspected, due to exclusion criteria lateral angle could be satisfactorily measured only in 101 temporal bones from 58 patients. The measurements did not differ significantly between sexes. An age-related, statistically significant decrease was observed for the entire pediatric sample studied, as well as for the males, but not for females. The measurements did not differ from side to side.The significant age-related decrease in lateral angle in male pediatric patients that was not detected in female counterparts may be the reflection of a sex-related difference in temporal bone development during childhood. Routine cranial MRI data may help investigators study age and sex-related changes in lateral angle in children.     

Evaluation the Weekly Intake of Some Wild Edible Indigenous Mushrooms Collected in Different Regions in Tunceli,Turkey

Biological Trace Element Research - The quantity of some essential and non-essential elements of wild edible mushroom samples collected from Tunceli Province of Turkey was determined by using flame...     

Characterization of Water-Soluble Complexes of Polyacrylic Acid with α-Amylase from <Emphasis Type="Italic">Aspergillus oryzae</Emphasis>

Polycomplex formation of α-Amylase from Aspergillus oryzae (TAKA) with polyacrylic acid (PAA) was studied by pH titration, fluorescence, and high performance liquid chromatography (HPLC) methods in water solutions. Acording to the our results, the complex formation and its solubility were depended on nature of enzyme and the pH of solutions. Both of them correlates isoelectric points (PI). The stability of PAA–amylase complexes was negligibly weak at pH 7 [pH > pI (isoelectric pH)]. Stable water-soluble polycomplexes were formed at pH 5 (pI ~4.5) and coexisted with free protein molecules. Insoluble complexes has been observed at pH < 4.5. The frozen storage stabilities of the obtained complexes were also studied by measuring the activities at different pH.     

Effects of continuous positive airway pressure on upper airway and respiratory muscle activity

To study the effects of continuous positive airway pressure (CPAP) on lung volume, and upper airway and respiratory muscle activity, we quantitated the CPAP-induced changes in diaphragmatic and genioglossal electromyograms, esophageal and transdiaphragmatic pressures (Pes and Pdi), and functional residual capacity (FRC) in six normal awake subjects in the supine position. CPAP resulted in increased FRC, increased peak and rate of rise of diaphragmatic activity (EMGdi and EMGdi/TI), decreased peak genioglossal activity (EMGge), decreased inspiratory time and inspiratory duty cycle (P less than 0.001 for all comparisons). Inspiratory changes in Pes and Pdi, as well as Pes/EMGdi and Pdi/EMGdi also decreased (P less than 0.001 for all comparisons), but mean inspiratory airflow for a given Pes increased (P less than 0.001) on CPAP. The increase in mean inspiratory airflow for a given Pes despite the decrease in upper airway muscle activity suggests that CPAP mechanically splints the upper airway. The changes in EMGge and EMGdi after CPAP application most likely reflect the effects of CPAP and the associated changes in respiratory system mechanics on the afferent input from receptors distributed throughout the intact respiratory system.