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D J Mewissen A S Ugarte J H Rust 《Comptes rendus des séances de la Société de biologie et de ses filiales》1984,178(2):230-235
An heritable multiple intestinal adenocarcinoma was observed in the offspring of an outcross between a male (or female) parent originating from our C57 Black/6M strain and his female (or male) mating counterpart originating from an experimental subline of the same strain, propagated following multigeneration exposure of the male parent to low level tritium, as drinking water (10 microCi/ml) for 35 days prior to mating. 相似文献
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Loree Heller Reynald Thinard Melanie Chevalier Sezgi Arpag Yu Jing Ruth Greferath Richard Heller Claude Nicolau 《Journal of cellular and molecular medicine》2020,24(15):8772-8778
In neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis, neuroinflammation can lead to blood‐brain barrier (BBB) breakdown. After intravenous or intra‐arterial injection into mice, endothelial progenitor cells (EPCs) home to the damaged BBB to promote neurovascular repair. Autologous EPCs transfected to express specific therapeutic proteins offer an innovative therapeutic option. Here, we demonstrate that EPC transfection by electroporation with plasmids encoding the reporter protein GFP or an anti‐β‐amyloid antibody fragment (Fab) leads to secretion of each protein. We also demonstrate the secreted anti‐β‐amyloid Fab protein functions in β‐amyloid aggregate solubilization. 相似文献
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Schlacher Thomas A. Gilby Ben L. Olds Andrew D. Henderson Christopher J. Connolly Rod M. Peterson Charles H. Voss Christine M. Maslo Brooke Weston Michael A. Bishop Melanie J. Rowden Ashley 《Ecosystems》2020,23(4):906-916
Ecosystems - Ecotones can form hot spots of biodiversity by containing species from multiple ecosystems. Because biodiversity is often linked to ecological function, we posit that rates of key... 相似文献
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Murray Kimberley R. Bird Melanie Strack Maria Cody Michael Xu Bin 《Wetlands Ecology and Management》2021,29(2):281-299
Wetlands Ecology and Management - Oil sands exploration activities across the Alberta boreal peatlands requires tree clearing and results in sites being left compressed and with altered understory... 相似文献
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Amy R. Sweeny Melanie Clerc Paulina A. Pontifes Saudamini Venkatesan Simon A. Babayan Amy B. Pedersen 《Proceedings. Biological sciences / The Royal Society》2021,288(1943)
Gastrointestinal (GI) helminths are common parasites of humans, wildlife, and livestock, causing chronic infections. In humans and wildlife, poor nutrition or limited resources can compromise an individual''s immune response, predisposing them to higher helminth burdens. This relationship has been tested in laboratory models by investigating infection outcomes following reductions of specific nutrients. However, much less is known about how diet supplementation can impact susceptibility to infection, acquisition of immunity, and drug efficacy in natural host–helminth systems. We experimentally supplemented the diet of wood mice (Apodemus sylvaticus) with high-quality nutrition and measured resistance to the common GI nematode Heligmosomoides polygyrus. To test whether diet can enhance immunity to reinfection, we also administered anthelmintic treatment in both natural and captive populations. Supplemented wood mice were more resistant to H. polygyrus infection, cleared worms more efficiently after treatment, avoided a post-treatment infection rebound, produced stronger general and parasite-specific antibody responses, and maintained better body condition. In addition, when applied in conjunction with anthelmintic treatment, supplemented nutrition significantly reduced H. polygyrus transmission potential. These results show the rapid and extensive benefits of a well-balanced diet and have important implications for both disease control and wildlife health under changing environmental conditions. 相似文献