全文获取类型
收费全文 | 774篇 |
免费 | 72篇 |
国内免费 | 1篇 |
专业分类
847篇 |
出版年
2022年 | 7篇 |
2021年 | 14篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2016年 | 17篇 |
2015年 | 24篇 |
2014年 | 28篇 |
2013年 | 34篇 |
2012年 | 47篇 |
2011年 | 37篇 |
2010年 | 39篇 |
2009年 | 18篇 |
2008年 | 41篇 |
2007年 | 33篇 |
2006年 | 36篇 |
2005年 | 31篇 |
2004年 | 20篇 |
2003年 | 27篇 |
2002年 | 28篇 |
2001年 | 21篇 |
2000年 | 25篇 |
1999年 | 14篇 |
1998年 | 13篇 |
1997年 | 7篇 |
1996年 | 5篇 |
1995年 | 9篇 |
1993年 | 12篇 |
1992年 | 9篇 |
1991年 | 10篇 |
1990年 | 17篇 |
1989年 | 19篇 |
1988年 | 13篇 |
1987年 | 13篇 |
1986年 | 5篇 |
1985年 | 6篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1973年 | 13篇 |
1972年 | 5篇 |
1971年 | 6篇 |
1970年 | 5篇 |
1958年 | 5篇 |
1956年 | 4篇 |
1954年 | 4篇 |
1951年 | 5篇 |
1950年 | 6篇 |
排序方式: 共有847条查询结果,搜索用时 15 毫秒
841.
842.
James J. McKenna 《Human nature (Hawthorne, N.Y.)》1990,1(2):145-177
This paper and its subsequent parts (Part II and Part III) build on an earlier publication (McKenna 1986). They suggest that
important clinical data on the relationship between infantile constitutional deficits and microenvironmental factors relevant
to SIDS can be acquired by examining the physiological regulatory effects (well documented among nonhuman primates) that parents
assert on their infants when they sleep together.
I attempt to show why access to parental sensory cues (movement, touch, smell, sound) that induce arousals in infants while
they sleep could possibly help one of many different subclasses of infants either to override certain kinds of sleep-induced
breathing control errors suspected to be involved in SIDS or to avoid them altogether. I do not suggest that solitary nocturnal
sleep “causes” SIDS, that all parents should sleep with their infants, or that traditional SIDS research strategies should
be abandoned. However, using evolutionary data, I do suggest that an adaptive fit exists between parent-infant sleep contact
and the natural physiological vulnerabilities of the neurologically immature human infant, whose breathing system is more
complex than that of other mammals owing to its speech-breathing abilities. This “fit” is best understood, it is argued, in
terms of the 4–5 million years of human evolution in which parent-infant contact was almost certainly continuous during at
least the first year of an infant’s life. Thus, to dismiss the idea that solitary sleep has no physiological consequences
for infants does not accord with scientific facts.
James J. McKenna is Associate Professor of Anthropology and Chair of the Department of Sociology and Anthropology at Pomona
College. He also has an appointment as an Adjunct Clinical Assistant Professor in the Departments of Pediatrics, Child Psychiatry,
and Human Behavior at the University of California, Irvine, School of Medicine. His primary research interests and many of
his publications concern aspects of primate parenting and infant development among both human and nonhuman primates. For the
past seven years he has been investigating from an anthropological perspective possible environmental correlates of the sudden
infant death syndrome (SIDS) and has just finished a preliminary study on the physiological correlates of human parent-infant
co-sleeping. His earlier monograph on the subject (cited in this paper) has received much international attention. He and
his colleagues (Mosko and Dungy) are the first to have used standard polysomnographic techniques to document simultaneously
human parent-infant co-sleeping. He has won three awards for distinguished teaching at Pomona College. 相似文献
843.
Dopamine inhibits angiotensin II-stimulated aldosterone production by an effect on the late phase of biosynthesis. This study was undertaken to investigate the effect of dopamine on potassium-stimulated aldosterone biosynthesis in adrenal glomerulosa cells in vitro. As potassium concentrations were increased from 0 to 12 mM, aldosterone production increased up to 6 mM potassium, but not beyond this concentration. Dopamine (10(-5)M) inhibited the aldosterone response to potassium. The effect of potassium on pregnenolone accumulation (the early phase of aldosterone biosynthesis) was assessed in cells treated with trilostane which inhibits the conversion of pregnenolone onward to aldosterone. Increasing potassium concentrations up to 12 mM gave increasing pregnenolone accumulation; however dopamine did not influence this effect. The potassium stimulated conversion of corticosterone to aldosterone, an index of activity in the late phase of aldosterone biosynthesis, was assessed using aminoglutethimide to prevent cholesterol side-chain cleavage. Significantly more corticosterone was converted to aldosterone at 6 mM potassium than at 0 or 12 mM; dopamine inhibited the conversion of corticosterone to aldosterone at 6 mM potassium. These data indicate that dopamine inhibits potassium-stimulated aldosterone production by an effect restricted to the late phase of the aldosterone biosynthetic pathway similar to its previously established effect on angiotensin II-stimulated aldosterone biosynthesis. 相似文献
844.
845.
Terence J. McKenna Donald P. Island Wendell E. Nicholson Grant M. Liddle 《Steroids》1978,32(1):127-136
Adrenal glands obtained from patients undergoing therapeutic adrenalectomy were used to study the effects of angiotensin on human adrenal steroidogenesis. It was observed that angiotensin stimulated cortisol biosynthesis. Although this has been demonstrated to occur in canine and bovine adrenals, angiotensin-induced cortisol biosynthesis has not been established in man. The possibility that angiotensin merely stimulated glomerulosa cells to secrete precursor steroids which accumulated in the medium and then diffused into fasciculata cells to provide substrate for cortisol biosynthesis was excluded by demonstrating that 3β-hydroxy-5-pregnen-20-one (pregnenolone) and progesterone (the only pertinent precursors) did not accumulate in angiotensinstimulated cell suspensions. In addition, angiotensin stimulated cortisol biosynthesis in a fasciculata cell suspension in which angiotensin did not stimulate aldosterone production. Therefore, in human adrenal cell suspensions angiotensin appeared to act directly to stimulate cortisol synthesis by fasciculata cells. In normal subjects pre-treated with dexamethasone, angiotensin infusions failed to stimulate an increase in plasma cortisol. The physiological importance of angiotensin as a regulator of cortisol secretion remains, therefore, to be established. 相似文献
846.
847.