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101.
Carney WP Schilling PW McKee AE Holderman BS Stunkard JA 《Journal of wildlife diseases》1970,6(4):422-429
Eurytrema procyonis is reported from the pancreatic ducts of domestic cats from North Carolina and Virginia. There were extensive histopathological alterations to the pancreas, especially the pancreatic ducts. However, there was no clinical evidence of infections. The incorporation of a synanthropic host in the life history of E. procyonis allows for rapid distribution of this fluke over its potential geographical range. 相似文献
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Víctor Faundes William G. Newman Laura Bernardini Natalie Canham Jill Clayton-Smith Bruno Dallapiccola Sally J. Davies Michelle K. Demos Amy Goldman Harinder Gill Rachel Horton Bronwyn Kerr Dhavendra Kumar Anna Lehman Shane McKee Jenny Morton Michael J. Parker Julia Rankin Siddharth Banka 《American journal of human genetics》2018,102(1):175-187
108.
Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain
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Sarah E. McKee Sisi Zhang Li Chen Joshua D. Rabinowitz Teresa M. Reyes 《Journal of neurochemistry》2018,145(5):362-373
109.
C P Tan K K McKee D H Weinberg T MacNeil O C Palyha S D Feighner D L Hreniuk L H Van Der Ploeg D J MacNeil A D Howard 《FEBS letters》1999,451(2):137-141
The primary hormonal regulator of pigmentation is melanocyte stimulating hormone derived from proopiomelanocortin by proteolytic processing. The melanocortin-1 receptor serves a key role in the regulation of pigmentation. We describe the identification of the first intron within a melanocortin receptor. A new melanocortin-1 receptor isoform, generated by alternative mRNA splicing, encodes an additional 65 amino acids at the predicted intracellular, C-terminal tail of the melanocortin-1 receptor. When expressed in heterologous cells, the new spliced form of the melanocortin-1 receptor (melanocortin-1 receptor B) appears pharmacologically similar to the non-spliced melanocortin-1 receptor. Melanocortin-1 receptor B is expressed in testis, fetal heart and melanomas. 相似文献
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Andrew G. McKee Charles P. Kuntz Joseph T. Ortega Hope Woods Victoria Most Francis J. Roushar Jens Meiler Beata Jastrzebska Jonathan P. Schlebach 《The Journal of biological chemistry》2021,297(6)
Membrane protein variants with diminished conformational stability often exhibit enhanced cellular expression at reduced growth temperatures. The expression of “temperature-sensitive” variants is also typically sensitive to corrector molecules that bind and stabilize the native conformation. There are many examples of temperature-sensitive rhodopsin variants, the misfolding of which is associated with the molecular basis of retinitis pigmentosa. In this work, we employ deep mutational scanning to compare the effects of reduced growth temperature and 9-cis-retinal, an investigational corrector, on the plasma membrane expression of 700 rhodopsin variants in HEK293T cells. We find that the change in expression at reduced growth temperatures correlates with the response to 9-cis-retinal among variants bearing mutations within a hydrophobic transmembrane domain (TM2). The most sensitive variants appear to disrupt a native helical kink within this transmembrane domain. By comparison, mutants that alter the structure of a polar transmembrane domain (TM7) exhibit weaker responses to temperature and retinal that are poorly correlated. Statistical analyses suggest that this observed insensitivity cannot be attributed to a single variable, but likely arises from the composite effects of mutations on the energetics of membrane integration, the stability of the native conformation, and the integrity of the retinal-binding pocket. Finally, we show that the characteristics of purified temperature- and retinal-sensitive variants suggest that the proteostatic effects of retinal may be manifested during translation and cotranslational folding. Together, our findings highlight several biophysical constraints that appear to influence the sensitivity of genetic variants to temperature and small-molecule correctors. 相似文献