全文获取类型
收费全文 | 871篇 |
免费 | 110篇 |
国内免费 | 1篇 |
出版年
2022年 | 5篇 |
2021年 | 17篇 |
2019年 | 5篇 |
2018年 | 10篇 |
2017年 | 13篇 |
2016年 | 13篇 |
2015年 | 25篇 |
2014年 | 22篇 |
2013年 | 26篇 |
2012年 | 34篇 |
2011年 | 41篇 |
2010年 | 27篇 |
2009年 | 41篇 |
2008年 | 37篇 |
2007年 | 33篇 |
2006年 | 41篇 |
2005年 | 44篇 |
2004年 | 29篇 |
2003年 | 40篇 |
2002年 | 25篇 |
2001年 | 36篇 |
2000年 | 31篇 |
1999年 | 36篇 |
1998年 | 19篇 |
1997年 | 22篇 |
1996年 | 14篇 |
1995年 | 10篇 |
1994年 | 13篇 |
1993年 | 11篇 |
1992年 | 15篇 |
1991年 | 24篇 |
1990年 | 21篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 15篇 |
1986年 | 11篇 |
1985年 | 13篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1978年 | 14篇 |
1977年 | 13篇 |
1976年 | 9篇 |
1975年 | 10篇 |
1974年 | 6篇 |
1973年 | 9篇 |
1971年 | 7篇 |
1968年 | 5篇 |
排序方式: 共有982条查询结果,搜索用时 15 毫秒
951.
Thomas R. Gaborski Michael N. Sealander Richard E. Waugh James L. McGrath 《European biophysics journal : EBJ》2013,42(11-12):851-855
Lateral organization and mobility of adhesion molecules play a significant role in determining the avidity with which cells can bind to target cells or surfaces. Recently, we have shown that the lateral mobility of the principal adhesion molecules on neutrophils is lower for rolling associated adhesion molecules (RAAMs: L-selectin and PSGL-1) than for β2 integrins (LFA-1 and Mac-1). Here we report that all four adhesion molecules exhibit distinct punctate distributions that are mobile on the cell surface. Using uniform illumination image correlation microscopy, we measure the lateral mobility of these topologically distinct domains. For all four molecules, we find that diffusion coefficients calculated from domain mobility agree with measurements we made previously using fluorescence recovery after photobleaching. This agreement indicates that the transport of receptors on the surface of the resting neutrophil is dominated by the lateral movement of domains rather than individual molecules. The diffusion of pre-assembled integrin domains to zones of neutrophil/endothelial contact may provide a mechanism to facilitate high avidity adhesion during the earliest stages of firm arrest. 相似文献
952.
953.
K. Lawlor A. M. Chaudri S. P. McGrath P. R. Hirsch 《Letters in applied microbiology》1999,28(4):317-320
Transfer of metal resistance plasmids into two pseudomonad recipients, Pseudomonas aureofaciens and Ps. putida , from soil bacteria donor populations, was investigated in agricultural soil contaminated predominantly with Zn and Cu. The putative donor and recipient numbers on selective agar were not affected by the concentration of metals in the soils, nor were the number of transconjugants. However, there were differences in transfer frequencies of Hg and Cu resistance from the different soil samples. This is the first time that transfer of Cu resistance has been observed from native bacteria present in agricultural soils. 相似文献
954.
Daorong Feng Jianwen Wei Sounak Gupta Barbara C McGrath Douglas R Cavener 《BMC cell biology》2009,10(1):61
Background
A deficiency in Perk (EIF2AK3) causes multiple neonatal defects in humans known as the Wolcott Rallison syndrome. Perk KO mice exhibit the same array of defects including permanent neonatal diabetes (PND). PND in mice was previously shown by us to be due to a decrease in beta cell proliferation and insulin secretion. The aim of this study was to determine if acute ablation of PERK in the 832/13 beta cells recapitulates these defects and to identify the primary molecular basis for beta cell dysfunction. 相似文献955.
Stefano Burgio Everly Conway de Macario Alberto JL Macario Francesco Cappello 《Cell stress & chaperones》2021,26(4):611
A few reports suggest that molecular mimicry can have a role in determining the more severe and deadly forms of COVID-19, inducing endothelial damage, disseminated intravascular coagulation, and multiorgan failure. Heat shock proteins/molecular chaperones can be involved in these molecular mimicry phenomena. However, tumor cells can display on their surface heat shock proteins/molecular chaperones that are mimicked by SARS-CoV-2 molecules (including the Spike protein), similarly to what happens in other bacterial or viral infections. Since molecular mimicry between SARS-CoV-2 and tumoral proteins can elicit an immune reaction in which antibodies or cytotoxic cells produced against the virus cross-react with the tumor cells, we want to prompt clinical studies to evaluate the impact of SARS-CoV-2 infection on prognosis and follow up of various forms of tumors. These topics, including a brief historical overview, are discussed in this paper. 相似文献
956.
Sean McGrath Hojoon Sohn Russell Steele Andrea Benedetti 《Biometrical journal. Biometrische Zeitschrift》2020,62(1):69-98
We consider the problem of meta-analyzing two-group studies that report the median of the outcome. Often, these studies are excluded from meta-analysis because there are no well-established statistical methods to pool the difference of medians. To include these studies in meta-analysis, several authors have recently proposed methods to estimate the sample mean and standard deviation from the median, sample size, and several commonly reported measures of spread. Researchers frequently apply these methods to estimate the difference of means and its variance for each primary study and pool the difference of means using inverse variance weighting. In this work, we develop several methods to directly meta-analyze the difference of medians. We conduct a simulation study evaluating the performance of the proposed median-based methods and the competing transformation-based methods. The simulation results show that the median-based methods outperform the transformation-based methods when meta-analyzing studies that report the median of the outcome, especially when the outcome is skewed. Moreover, we illustrate the various methods on a real-life data set. 相似文献
957.
958.
A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers. 总被引:7,自引:0,他引:7
下载免费PDF全文
![点击此处可从《American journal of human genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
959.
960.