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91.
92.
COLIN J. YATES JANE ELITH ANDREW M. LATIMER DAVID LE MAITRE GUY F. MIDGLEY FRANK M. SCHURR ADAM G. WEST 《Austral ecology》2010,35(4):374-391
Increasing evidence shows that anthropogenic climate change is affecting biodiversity. Reducing or stabilizing greenhouse gas emissions may slow global warming, but past emissions will continue to contribute to further unavoidable warming for more than a century. With obvious signs of difficulties in achieving effective mitigation worldwide in the short term at least, sound scientific predictions of future impacts on biodiversity will be required to guide conservation planning and adaptation. This is especially true in Mediterranean type ecosystems that are projected to be among the most significantly affected by anthropogenic climate change, and show the highest levels of confidence in rainfall projections. Multiple methods are available for projecting the consequences of climate change on the main unit of interest – the species – with each method having strengths and weaknesses. Species distribution models (SDMs) are increasingly applied for forecasting climate change impacts on species geographic ranges. Aggregation of models for different species allows inferences of impacts on biodiversity, though excluding the effects of species interactions. The modelling approach is based on several further assumptions and projections and should be treated cautiously. In the absence of comparable approaches that address large numbers of species, SDMs remain valuable in estimating the vulnerability of species. In this review we discuss the application of SDMs in predicting the impacts of climate change on biodiversity with special reference to the species‐rich South West Australian Floristic Region and South African Cape Floristic Region. We discuss the advantages and challenges in applying SDMs in biodiverse regions with high levels of endemicity, and how a similar biogeographical history in both regions may assist us in understanding their vulnerability to climate change. We suggest how the process of predicting the impacts of climate change on biodiversity with SDMs can be improved and emphasize the role of field monitoring and experiments in validating the predictions of SDMs. 相似文献
93.
94.
Rothman RB Cadet JL Dersch CM McCoy MT Lehrmann E Becker KG Bader M Alenina N Baumann MH 《PloS one》2011,6(3):e17735
The use of fenfluramines can increase the risk of developing pulmonary arterial hypertension (PAH) in humans, but the mechanisms responsible are unresolved. A recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (Tph1(-/-) mice) were protected from PAH caused by chronic dexfenfluramine, suggesting a pivotal role for peripheral serotonin (5-HT) in the disease process. Here we tested two alternative hypotheses which might explain the lack of dexfenfluramine-induced PAH in Tph1(-/-) mice. We postulated that: 1) Tph1(-/-) mice express lower levels of pulmonary 5-HT transporter (SERT) when compared to wild-type controls, and 2) Tph1(-/-) mice display adaptive changes in the expression of non-serotonergic pulmonary genes which are implicated in PAH. SERT was measured using radioligand binding methods, whereas gene expression was measured using microarrays followed by quantitative real time PCR (qRT-PCR). Contrary to our first hypothesis, the number of pulmonary SERT sites was modestly up-regulated in female Tph1(-/-) mice. The expression of 51 distinct genes was significantly altered in the lungs of female Tph1(-/-) mice. Consistent with our second hypothesis, qRT-PCR confirmed that at least three genes implicated in the pathogenesis of PAH were markedly up-regulated: Has2, Hapln3 and Retlna. The finding that female Tph1(-/-) mice are protected from dexfenfluramine-induced PAH could be related to compensatory changes in pulmonary gene expression, in addition to reductions in peripheral 5-HT. These observations emphasize the intrinsic limitation of interpreting data from studies conducted in transgenic mice that are not fully characterized. 相似文献
95.
Schrey AW Grispo M Awad M Cook MB McCoy ED Mushinsky HR Albayrak T Bensch S Burke T Butler LK Dor R Fokidis HB Jensen H Imboma T Kessler-Rios MM Marzal A Stewart IR Westerdahl H Westneat DF Zehtindjiev P Martin LB 《Molecular ecology》2011,20(6):1133-1143
Introduced species offer unique opportunities to study evolution in new environments, and some provide opportunities for understanding the mechanisms underlying macroecological patterns. We sought to determine how introduction history impacted genetic diversity and differentiation of the house sparrow (Passer domesticus), one of the most broadly distributed bird species. We screened eight microsatellite loci in 316 individuals from 16 locations in the native and introduced ranges. Significant population structure occurred between native than introduced house sparrows. Introduced house sparrows were distinguished into one North American group and a highly differentiated Kenyan group. Genetic differentiation estimates identified a high magnitude of differentiation between Kenya and all other populations, but demonstrated that European and North American samples were differentiated too. Our results support previous claims that introduced North American populations likely had few source populations, and indicate house sparrows established populations after introduction. Genetic diversity also differed among native, introduced North American, and Kenyan populations with Kenyan birds being least diverse. In some cases, house sparrow populations appeared to maintain or recover genetic diversity relatively rapidly after range expansion (<50 years; Mexico and Panama), but in others (Kenya) the effect of introduction persisted over the same period. In both native and introduced populations, genetic diversity exhibited large-scale geographic patterns, increasing towards the equator. Such patterns of genetic diversity are concordant with two previously described models of genetic diversity, the latitudinal model and the species diversity model. 相似文献
96.
Understory vegetation as an indicator for floodplain forest restoration in the Mississippi River Alluvial Valley,U.S.A. 下载免费PDF全文
Diane De Steven Stephen P. Faulkner Bobby D. Keeland Michael J. Baldwin John W. McCoy Steven C. Hughes 《Restoration Ecology》2015,23(4):402-412
In the Mississippi River Alluvial Valley (MAV), complete alteration of river‐floodplain hydrology allowed for widespread conversion of forested bottomlands to intensive agriculture, resulting in nearly 80% forest loss. Governmental programs have attempted to restore forest habitat and functions within this altered landscape by the methods of tree planting (afforestation) and local hydrologic enhancement on reclaimed croplands. Early assessments identified factors that influenced whether planting plus tree colonization could establish an overstory community similar to natural bottomland forests. The extent to which afforested sites develop typical understory vegetation has not been evaluated, yet understory composition may be indicative of restored site conditions. As part of a broad study quantifying the ecosystem services gained from restoration efforts, understory vegetation was compared between 37 afforested sites and 26 mature forest sites. Differences in vegetation attributes for species growth forms, wetland indicator classes, and native status were tested with univariate analyses; floristic composition data were analyzed by multivariate techniques. Understory vegetation of restoration sites was generally hydrophytic, but species composition differed from that of mature bottomland forest because of young successional age and differing responses of plant growth forms. Attribute and floristic variation among restoration sites was related to variation in canopy development and local wetness conditions, which in turn reflected both intrinsic site features and outcomes of restoration practices. Thus, understory vegetation is a useful indicator of functional progress in floodplain forest restoration. 相似文献
97.
JULES ANGST THOMAS D. MEYER ROLF ADOLFSSON PETER SKEPPAR MAURO CARTA FRANCO BENAZZI RU‐BAND LU YI‐HSUAN WU HAI‐CHEN YANG CHENG‐MEI YUAN PAOLO MORSELLI PETER BRIEGER JUDITH KATZMANN INES ALICE TEIXEIRA LEÃO JOSÉ ALBERTO DEL PORTO DORIS HUPFELD MORENO RICARDO A. MORENO ODEILTON T. SOARES EDUARD VIETA ALEX GAMMA 《World psychiatry》2010,9(1):41-49
This study examined the transcultural robustness of a screening instrument
for hypomania, the Hypomania Checklist-32, first revised version (HCL-32 R1).
It was carried out in 2606 patients from twelve countries in five geographic
regions (Northern, Southern and Eastern Europe, South America and East Asia).
In addition, GAMIAN Europe contributed data from its members. Exploratory
and confirmatory factor analyses were used to examine the transregional stability
of the measurement properties of the HCL-32 R1, including the influence of
sex and age as covariates. Across cultures, a two-factor structure was confirmed:
the first factor (F1) reflected the more positive aspects of hypomania (being
more active, elated, self-confident, and cogni-tively enhanced); the second
factor (F2) reflected the more negative aspects (being irritable, impulsive,
careless, more substance use). The measurement properties of the HCL-32 R1
were largely invariant across cultures. Only few items showed transcultural
differences in their relation to hypomania as measured by the test. F2 was
higher among men and in more severe manic syndromes; F1 was highest in North
and East Europe and lowest in South America. The scores decreased slightly
with age. The frequency of the 32 items showed remarkable similarities across
geographic areas, with two excep-tions: South Europeans had lower symptom
frequencies in general and East Europeans higher rates of substance use. These
findings support the interna-tional applicability of the HCL-32 R1 as a screening
instrument for hypomania. 相似文献
98.
Mannaioni G Orr AG Hamill CE Yuan H Pedone KH McCoy KL Berlinguer Palmini R Junge CE Lee CJ Yepes M Hepler JR Traynelis SF 《The Journal of biological chemistry》2008,283(29):20600-20611
Protease-activated receptor-1 (PAR1) is activated by a number of serine proteases, including plasmin. Both PAR1 and plasminogen, the precursor of plasmin, are expressed in the central nervous system. In this study we examined the effects of plasmin in astrocyte and neuronal cultures as well as in hippocampal slices. We find that plasmin evokes an increase in both phosphoinositide hydrolysis (EC(50) 64 nm) and Fura-2/AM fluorescence (195 +/- 6.7% above base line, EC(50) 65 nm) in cortical cultured murine astrocytes. Plasmin also activates extracellular signal-regulated kinase (ERK1/2) within cultured astrocytes. The plasmin-induced rise in intracellular Ca(2+) concentration ([Ca(2+)](i)) and the increase in phospho-ERK1/2 levels were diminished in PAR1(-/-) astrocytes and were blocked by 1 microm BMS-200261, a selective PAR1 antagonist. However, plasmin had no detectable effect on ERK1/2 or [Ca(2+)](i) signaling in primary cultured hippocampal neurons or in CA1 pyramidal cells in hippocampal slices. Plasmin (100-200 nm) application potentiated the N-methyl-D-aspartate (NMDA) receptor-dependent component of miniature excitatory postsynaptic currents recorded from CA1 pyramidal neurons but had no effect on alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate- or gamma-aminobutyric acid receptor-mediated synaptic currents. Plasmin also increased NMDA-induced whole cell receptor currents recorded from CA1 pyramidal cells (2.5 +/- 0.3-fold potentiation over control). This effect was blocked by BMS-200261 (1 microm; 1.02 +/- 0.09-fold potentiation over control). These data suggest that plasmin may serve as an endogenous PAR1 activator that can increase [Ca(2+)](i) in astrocytes and potentiate NMDA receptor synaptic currents in CA1 pyramidal neurons. 相似文献
99.
Jane M. Natividad Xianxi Huang Emma Slack Jennifer Jury Yolanda Sanz Chella David Emmanuel Denou Pinchang Yang Joseph Murray Kathy D. McCoy Elena F. Verdú 《PloS one》2009,4(7)
Background and Aims
Excessive uptake of commensal bacterial antigens through a permeable intestinal barrier may influence host responses to specific antigen in a genetically predisposed host. The aim of this study was to investigate whether intestinal barrier dysfunction induced by indomethacin treatment affects the host response to intestinal microbiota in gluten-sensitized HLA-DQ8/HCD4 mice.Methodology/Principal Findings
HLA-DQ8/HCD4 mice were sensitized with gluten, and gavaged with indomethacin plus gluten. Intestinal permeability was assessed by Ussing chamber; epithelial cell (EC) ultra-structure by electron microscopy; RNA expression of genes coding for junctional proteins by Q-real-time PCR; immune response by in-vitro antigen-specific T-cell proliferation and cytokine analysis by cytometric bead array; intestinal microbiota by fluorescence in situ hybridization and analysis of systemic antibodies against intestinal microbiota by surface staining of live bacteria with serum followed by FACS analysis. Indomethacin led to a more pronounced increase in intestinal permeability in gluten-sensitized mice. These changes were accompanied by severe EC damage, decreased E-cadherin RNA level, elevated IFN-γ in splenocyte culture supernatant, and production of significant IgM antibody against intestinal microbiota.Conclusion
Indomethacin potentiates barrier dysfunction and EC injury induced by gluten, affects systemic IFN-γ production and the host response to intestinal microbiota antigens in HLA-DQ8/HCD4 mice. The results suggest that environmental factors that alter the intestinal barrier may predispose individuals to an increased susceptibility to gluten through a bystander immune activation to intestinal microbiota. 相似文献100.
J Daugherty TM Evans T Skillom LE Watson NP Money 《Fungal genetics and biology : FG & B》1998,24(3):354-363
Classical studies on spore release within the Saprolegniaceae (Oomycetes) led to the proposition that different mechanisms of sporangial emptying represent steps in an evolutionary transition series. We have reevaluated this idea in a phylogenetic framework using internal transcribed spacer sequences of four genera. These data were compared with the response to osmotic stress exhibited by each taxon. Saprolegnia emerges as the most basal genus, sister to Achlya, Thraustotheca, and Dictyuchus. Achlya and Thraustotheca are most closely related, while Dictyuchus appears to have evolved along a separate evolutionary lineage. The resulting phylogenetic framework is consistent with the idea that the mechanism of sporangial emptying exhibited by Saprolegnia represents the plesiomorphic condition from which the other mechanisms were derived independently. These alternative mechanisms of spore release may have resulted from a small number of mutations that inhibited axonemal development and altered the temporal and spatial expression of lytic enzymes that degrade the sporangial wall. Copyright 1998 Academic Press. 相似文献