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141.
Karen L Svenson Molly A Bogue Luanne L Peters 《Journal of applied physiology》2003,94(4):1650-9; discussion 1673
The mouse is a proven model for studying human disease. Many strains exist that exhibit either natural or engineered genetic variation and thereby enable the elucidation of pathways involved in the development of cardiovascular disease. Although those mouse models have been fundamental to advancing our knowledge base, we are still at an early stage in understanding how genes contribute to complex disorders. There remains a need for new animal models that closely represent human disease. To expedite their development, we have established the Center for New Mouse Models of Heart, Lung, Blood, and Sleep Disorders at The Jackson Laboratory. We are using a phenotype-driven approach to identify mutations leading to atherosclerosis, hypertension, obesity, blood disorders, lung dysfunction, thrombosis, and disordered sleep. Our high-throughput, comprehensive phenotyping draws from two sources for new models: 1) the natural variation among over 40 inbred mouse strains and 2) chemically induced, whole-genome mutagenized mice. Here, we review our cardiovascular screens and present some hypertensive, obese, and cardiovascular models identified with this approach. 相似文献
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Molly Lee 《American anthropologist》2000,102(2):421-422
Trading Identities: The Souvenir in Native North American Art from the Northeast, 1700-1900. Ruth B. Phillips. Seattle: University of Washington Press, 1998. 334 pp. 相似文献
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CTP:cholinephosphate cytidylyltransferase (EC 2.7.7.15) was purified from pea (Pisum sativum) stems. The purification involved ammonium sulphate fractionation, ion exchange chromatography, removal of proteases with α2-macroglobulin and gel filtration. The purified enzyme had Km values for phosphorylcholine and CTP of 2.1 mM and 0.55 mM respectively. It was found to have a pH optimum of 7.5, a requirement for Mg2+ and an Mr of 56000. It could not utilize phosphorylethanolamine and its activity was not stimulated by added phospholipids. 相似文献
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A Technique for the Temporary Application and Augmentation of Pigment Patterns in Fish 总被引:3,自引:0,他引:3
Chad D. Hoefler & Molly R. Morris 《Ethology : formerly Zeitschrift fur Tierpsychologie》1999,105(5):431-438
Secondary sexual characteristics, such as pigment patterns in male fish, have significant roles in female mating preferences. Vertical body-bar pigmentation, one such characteristic, is found in a variety of Xiphophorus species. Prior investigations have revealed that these bars function as a signal attracting females and deterring rival males in at least two species. Furthermore, it has been shown that X. cortezi females prefer vertical bar symmetry as well as more bars in conspecific males. Because of the shortcomings of prior techniques used for pigment elimination and permanent color marking, a temporary method for augmenting pigment patterns with an artificial dye was developed. This technique was tested using the known preference that female X. cortezi have for more bars in conspecific males. The results corroborate previous findings as female X. cortezi preferred males with more artificial vertical bars in comparison with males with fewer. Therefore, the method of applying temporary, artificial pigment patterns using an antiseptic dye would appear to be an effective way to control and manipulate secondary sexual pigmentation for behavioral investigations in fish. 相似文献