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941.
Qiang Liu Shilong Piao Matteo Campioli Mengdi Gao Yongshuo H. Fu Kai Wang Yue He Xiangyi Li Ivan A. Janssens 《Global Change Biology》2020,26(7):4104-4118
Autumnal leaf senescence signals the end of photosynthetic activities in temperate deciduous trees and consequently exerts a strong control on various ecological processes. Predicting leaf senescence dates (LSD) with high accuracy is thus a prerequisite for better understanding the climate–ecosystem interactions. However, modeling LSD at large spatial and temporal scales is challenging. In this study, first, we used 19972 site‐year records (848 sites and four deciduous tree species) from the PAN European Phenology network to calibrate and evaluate six leaf senescence models during the period 1980–2013. Second, we extended the spatial analysis by repeating the procedure across Europe using satellite‐derived end of growing season and a forest map. Overall, we found that models that considered photoperiod and temperature interactions outperformed models using simple temperature or photoperiod thresholds for Betula pendula, Fagus sylvatica and Quercus robur. On the contrary, no model displayed reasonable predictions for Aesculus hippocastanum. This inter‐model comparison indicates that, contrary to expectation, photoperiod does not significantly modulate the accumulation of cooling degree days (CDD). On the other hand, considering the carryover effect of leaf unfolding date could promote the models’ predictability. The CDD models generally matched the observed LSD at species level and its interannual variation, but were limited in explaining the inter‐site variations, indicating that other environmental cues need to be considered in future model development. The discrepancies remaining between model simulations and observations highlight the need of manipulation studies to elucidate the mechanisms behind the leaf senescence process and to make current models more realistic. 相似文献
942.
Fabio Pranovi Simone Libralato Matteo Zucchetta Marco Anelli Monti Jason S. Link 《Global Change Biology》2020,26(2):786-797
Implementing the Ecosystem Approach in marine ecosystems is moving from preliminary steps—dedicated to defining the optimal features for indicators and developing efficient indicator frameworks—towards an operational phase where multisector marine management decisions are executed using this information. Within this operational context, emergent ecosystem properties are becoming quite promising as they have been demonstrated to be globally widespread and repeatable, and to be quite effective in detecting significant state variations of complex systems. Biomass accumulation across TLs (CumB‐TL) combines two important emergent properties of an ecosystem (energy flow, in terms of transfer efficiency, and storage, expressed as biomass), both amenable to detecting rapid ecosystem change. However, for further application, it is crucial to understand which types of drivers an indicator is sensitive to and how robust it is in relation to modifications of the external conditions and/or the system state. Here we address some outstanding questions of these CumB‐TL curves related to their sensitivity to various drivers by carrying out a global scale assessment (using data from 62 LMEs) over six decades (1950–2010). We confirm the consistency of the S‐pattern across all the LMEs, independent from latitude, ecosystem, environmental conditions, and stress level. The dynamics of the curve shape showed a tendency to stretch (i.e. decrease of steepness), in the presence of external disturbance and conversely to increase in steepness and shift towards higher TL in the case of recovery from stressed conditions. Our results suggest the presence of three main types of ecosystem dynamics, those showing an almost continuous increase in ecological state over time, those showing a continuous decrease in ecological state over time, and finally those showing a mixed behaviour flipping between recovering and degrading phases. These robust patterns suggest that the CumB‐TL curve approach has some useful properties for use in further advancing the implementation of the Ecosystem Approach, allowing us to detect the state of a given marine ecosystem based on the dynamics of its curve shape, by using readily available time series data. The value of being able to identify conditions that might require management actions is quite high and, in many respects, represents the main objective in the context of an Ecosystem Approach, with large applications for detecting and responding to global changes in marine ecosystems. 相似文献
943.
Matteo Saladini Monica Nizzardo Alessandra Govoni Michela Taiana Nereo Bresolin Giacomo P. Comi Stefania Corti 《Journal of cellular and molecular medicine》2020,24(2):1169-1178
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a rare autosomal recessive neuromuscular disorder caused by mutations in the IGHMBP2 gene, which encodes immunoglobulin μ‐binding protein 2, leading to progressive spinal motor neuron degeneration. We review the data available in the literature about SMARD1. The vast majority of patients show an onset of typical symptoms in the first year of life. The main clinical features are distal muscular atrophy and diaphragmatic palsy, for which permanent supportive ventilation is required. No effective treatment is available yet, but novel therapeutic approaches, such as gene therapy, have shown encouraging results in preclinical settings and thus represent possible methods for treating SMARD1. Significant advancements in the understanding of both the SMARD1 clinical spectrum and its molecular mechanisms have allowed the rapid translation of preclinical therapeutic strategies to human patients to improve the poor prognosis of this devastating disease. 相似文献
944.
Caroline F. Wright Nicholas M. Quaife Laura Ramos-Hernández Petr Danecek Matteo P. Ferla Kaitlin E. Samocha Joanna Kaplanis Eugene J. Gardner Ruth Y. Eberhardt Katherine R. Chao Konrad J. Karczewski Joannella Morales Giuseppe Gallone Meena Balasubramanian Siddharth Banka Lianne Gompertz Bronwyn Kerr Amelia Kirby Nicola Whiffin 《American journal of human genetics》2021,108(6):1083-1094
945.
Gregorio Oxilia Eugenio Bortolini Federica Badino Federico Bernardini Valentina Gazzoni Federico Lugli Matteo Romandini Anita Radini Gabriele Terlato Giulia Marciani Sara Silvestrini Jessica C. Menghi Sartorio Ursula Thun Hohenstein Luca Fiorenza Ottmar Kullmer Claudio Tuniz Jacopo Moggi Cecchi Sahra Talamo Federica Fontana Marco Peresani Stefano Benazzi Emanuela Cristiani 《American journal of physical anthropology》2021,174(2):232-253
946.
Gregorio Oxilia Jessica C. Menghi Sartorio Eugenio Bortolini Giulia Zampirolo Andrea Papini Marco Boggioni Sergio Martini Filippo Marciani Simona Arrighi Carla Figus Giulia Marciani Matteo Romandini Sara Silvestrini Maria Elena Pedrosi Tommaso Mori Alessandro Riga Ottmar Kullmer Rachel Sarig Luca Fiorenza Melchiore Giganti Rita Sorrentino Maria Giovanna Belcastro Jacopo Moggi Cecchi Stefano Benazzi 《American journal of physical anthropology》2021,175(4):847-864
947.
Nuclear molecules control the functional properties of the chromatin fiber by shaping its morphological properties. The biophysical mechanisms controlling how bridging molecules compactify chromatin are a matter of debate. On the one side, bridging molecules could cross-link faraway sites and fold the fiber through the formation of loops. Interacting bridging molecules could also mediate long-range attractions by first tagging different locations of the fiber and then undergoing microphase separation. Using a coarse-grained model and Monte Carlo simulations, we study the conditions leading to compact configurations both for interacting and noninteracting bridging molecules. In the second case, we report on an unfolding transition at high densities of the bridging molecules. We clarify how this transition, which disappears for interacting bridging molecules, is universal and controlled by entropic terms. In general, chains are more compact in the case of interacting bridging molecules because interactions are not valence limited. However, this result is conditional on the ability of our simulation methodology to relax the system toward its ground state. In particular, we clarify how, unless using reaction dynamics that change the length of a loop in a single step, the system is prone to remain trapped in metastable, compact configurations featuring long loops. 相似文献
948.
Marianna Carinci Beatrice Testa Matteo Bordi Giacomo Milletti Massimo Bonora Laura Antonucci Caterina Ferraina Marta Carro Mukesh Kumar Donatella Ceglie Franziska Eck Roberta Nardacci Francois le Guerrou Stefania Petrini Maria E Soriano Ignazio Caruana Valentina Doria Maria Manifava Camille Peron Matteo Lambrughi Valeria Tiranti Christian Behrends Elena Papaleo Paolo Pinton Carlotta Giorgi Nicholas T Ktistakis Franco Locatelli Francesca Nazio Francesco Cecconi 《The EMBO journal》2021,40(10)
The early secretory pathway and autophagy are two essential and evolutionarily conserved endomembrane processes that are finely interlinked. Although growing evidence suggests that intracellular trafficking is important for autophagosome biogenesis, the molecular regulatory network involved is still not fully defined. In this study, we demonstrate a crucial effect of the COPII vesicle‐related protein TFG (Trk‐fused gene) on ULK1 puncta number and localization during autophagy induction. This, in turn, affects formation of the isolation membrane, as well as the correct dynamics of association between LC3B and early ATG proteins, leading to the proper formation of both omegasomes and autophagosomes. Consistently, fibroblasts derived from a hereditary spastic paraparesis (HSP) patient carrying mutated TFG (R106C) show defects in both autophagy and ULK1 puncta accumulation. In addition, we demonstrate that TFG activity in autophagy depends on its interaction with the ATG8 protein LC3C through a canonical LIR motif, thereby favouring LC3C‐ULK1 binding. Altogether, our results uncover a link between TFG and autophagy and identify TFG as a molecular scaffold linking the early secretion pathway to autophagy. 相似文献
949.
Brenes-Peralta Laura Jiménez-Morales María Fernanda Campos-Rodríguez Rooel Vittuari Matteo 《The International Journal of Life Cycle Assessment》2021,26(10):2056-2071
The International Journal of Life Cycle Assessment - Several frameworks coincide in the importance of addressing social impacts to ensure sustainability. However, the agri-food sector, regarded as... 相似文献
950.