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921.
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923.
Verónica Crespo-Pérez Olivier Dangles Cristina Ibarra Rodrigo Espinosa Patricio Andino Dean Jacobsen Sophie Cauvy-Fraunié 《Freshwater Biology》2020,65(8):1348-1362
- In many mountainous areas, glaciers feed streams characterised by harsh environmental conditions, such as low water temperature, high turbidity, low channel stability, and high temporal variability in flow. Additionally, in many glacierised catchments, the mixture of streams arising from different water sources (glacier melt, groundwater, rainfall) generates high levels of environmental heterogeneity, which enhance species turnover rates and increase regional diversity.
- Studies from mainly temperate regions have revealed some consistent patterns: a predominance of traits adaptive to harsh environmental conditions and reduced functional diversity with increased glaciality, both strongly related to environmental filtering. Here, we investigated variation in functional structure and diversity between macroinvertebrate communities from 15 stream sites, with different water sources (five glacier-fed, five groundwater-fed, and five mixed source) and level of glacier influence, in a glacierised catchment in the Ecuadorian Andes.
- Our results revealed functional differences between communities inhabiting the different stream types. As found in temperate regions, high levels of glaciality were associated with an increase of small-sized taxa that do not swim but are temporarily attached to or burrow in the substrate, have a flying-adult stage, and feed by collecting–gathering. Similarly, we found a general decrease in functional diversity at sites with higher glacier influence. A null modelling approach suggested that in some of our glacier-fed sites, environmental filtering may be the main driver of community assembly, whereas other mechanisms, mainly regional (such as dispersal), but also local (such as intraspecific competition), may gain importance as glacier influence decreases.
- Assemblage composition in streams in tropical glacierised catchments may be driven by both local and regional processes that generate a gradient of decreasing functional diversity with stronger glacier influence. However, lack of knowledge of relevant traits for taxa in tropical glacierised streams currently poses a substantial obstacle to predicting changes likely to arise from global warming and glacier melt in this region.
924.
Juan Diego Maya Bruce K. Cassels Patricio Iturriaga-Vsquez Jorge Ferreira Mario Faúndez Norbel Galanti Arturo Ferreira Antonio Morello 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》2007,146(4):601
Current knowledge of the biochemistry of Trypanosoma cruzi has led to the development of new drugs and the understanding of their mode of action. Some trypanocidal drugs such as nifurtimox and benznidazole act through free radical generation during their metabolism. T. cruzi is very susceptible to the cell damage induced by these metabolites because enzymes scavenging free radicals are absent or have very low activities in the parasite. Another potential target is the biosynthetic pathway of glutathione and trypanothione, the low molecular weight thiol found exclusively in trypanosomatids. These thiols scavenge free radicals and participate in the conjugation and detoxication of numerous drugs. Inhibition of this key pathway could render the parasite much more susceptible to the toxic action of drugs such as nifurtimox and benznidazole without affecting the host significantly. Other drugs such as allopurinol and purine analogs inhibit purine transport in T. cruzi, which cannot synthesize purines de novo. Nitroimidazole derivatives such as itraconazole inhibit sterol metabolism. The parasite's respiratory chain is another potential therapeutic target because of its many differences with the host enzyme complexes. The pharmacological modulation of the host's immune response against T. cruzi infection as a possible chemotherapeutic target is discussed. A large set of chemicals of plant origin and a few animal metabolites active against T. cruzi are enumerated and their likely modes of action are briefly discussed. 相似文献
925.
Guadalupe Valdés Sonia V. González Dania López García Patricio Márquez 《Anthropology & education quarterly》2003,34(1):3-26
In this article we investigate language ideology in a department of Spanish. We are concerned with examining the acquisition and transmission of linguistic culture in departments of foreign languages within university settings and the ways in which views about non-English languages that are part of the American cultural dialogue are maintained and nurtured by educational institutions. Using long-term participant-observation data and focused interviews, we contend that foreign language departments in U.S. colleges and universities, although involved in a nonhegemonic practice—that is, in the teaching of non-English languages—are nevertheless working in concert with deeply held American ideologies about bilingualism and monolingualism. 相似文献
926.
Ivone de Bem Oliveira Rodrigo Rampazo Amadeu Luis Felipe Ventorim Ferro Patricio R. Muoz 《Heredity》2020,125(6):437
Blueberry (Vaccinium spp.) is an important autopolyploid crop with significant benefits for human health. Apart from its genetic complexity, the feasibility of genomic prediction has been proven for blueberry, enabling a reduction in the breeding cycle time and increasing genetic gain. However, as for other polyploid crops, sequencing costs still hinder the implementation of genome-based breeding methods for blueberry. This motivated us to evaluate the effect of training population sizes and composition, as well as the impact of marker density and sequencing depth on phenotype prediction for the species. For this, data from a large real breeding population of 1804 individuals were used. Genotypic data from 86,930 markers and three traits with different genetic architecture (fruit firmness, fruit weight, and total yield) were evaluated. Herein, we suggested that marker density, sequencing depth, and training population size can be substantially reduced with no significant impact on model accuracy. Our results can help guide decisions toward resource allocation (e.g., genotyping and phenotyping) in order to maximize prediction accuracy. These findings have the potential to allow for a faster and more accurate release of varieties with a substantial reduction of resources for the application of genomic prediction in blueberry. We anticipate that the benefits and pipeline described in our study can be applied to optimize genomic prediction for other diploid and polyploid species. 相似文献
927.
Samuel Zamora Eladio Lin Patricio Domínguez Alonso Rodolfo Gozalo Jos A. Gmez Vintaned 《Annales de Paléontologie》2007,93(4):249-260
A Middle Cambrian edrioasteroid belonging to the genus Cambraster is described from the Middle Cambrian Murero biota (Cadenas Ibéricas, NE Spain). Up to now, this genus was known only from Australia and France. This represents the first record of the class Edrioasteroidea in the Cambrian of Spain. Moreover, preliminary results on the diversity and biostratigraphic position of Cincta, Eocrinoidea and Edrioasteroidea from this area are reported. 相似文献
928.
Heinze Christin Dundão Mateus Domingos Francisco Neinhuis Christoph Lautenschläger Thea 《Economic botany》2019,73(1):96-111
Economic Botany - This study examines the economic potential of 12 native Angolan plant species. In October/November 2016, field trips and market analyses were conducted in the province of Cuanza... 相似文献
929.
Seth B Roberts Jennifer L Robichaux Arvind K Chavali Patricio A Manque Vladimir Lee Ana M Lara Jason A Papin Gregory A Buck 《BMC systems biology》2009,3(1):52
Background
Trypanosoma cruzi is a Kinetoplastid parasite of humans and is the cause of Chagas disease, a potentially lethal condition affecting the cardiovascular, gastrointestinal, and nervous systems of the human host. Constraint-based modeling has emerged in the last decade as a useful approach to integrating genomic and other high-throughput data sets with more traditional, experimental data acquired through decades of research and published in the literature. 相似文献930.