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661.
Ohne Zusammenfassung 相似文献
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Die Autorinnen legen drei neuen Fachausdrücke für die an Samen der FamilieFabaceae festgestellten Gebilde for. Macula cicatricularis—ein Makel um die Narbe (cicatricula), macula raphalis—ein Makel um die Sammennaht (raphe), und fissum hilare—eine linienförmige Vertiefung inmitten des Nabels (hilum). 相似文献
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Petronela Žižková Dušan Blaškovič Magdaléna Májeková L’ubomír Švorc Lucia Račková L’ubica Ratkovská Miroslav Veverka L’ubica Horáková 《Molecular and cellular biochemistry》2014,386(1-2):1-14
Sarco/endoplasmic reticulum calcium ATP-ase (SERCA) is regulated by low concentrations of peroxynitrite and inhibited by high levels, as indicated in human diseases. We studied quercetin (Q) and its novel derivatives monochloropivaloylquercetin (MPQ) and chloronaphthoquinonequercetin (CHQ) as agents with expected preventive properties against peroxynitrite-induced SERCA impairment. Q and MPQ protected the SERCA1 against peroxynitrite induced activity decrease, while CHQ potentiated the inhibitory effect of peroxynitrite. Quercetin derivatives were found to be weaker antioxidants compared with Q, as indicated by their ability to scavenge peroxynitrite and prevent of SERCA1 carbonylation, both decreasing in the order (Q > MPQ > CHQ). Quantum-chemical values of theoretical parameter E HOMO also indicated lower antioxidant capacities for MPQ and CHQ. Prooxidant properties estimated by calculations of frontier molecular orbitals (E LUMO) correlated with experimentally determined SH-group decrease induced by the compounds studied. Both methods showed a decrease of prooxidant properties as follows: CHQ > MPQ > Q. In addition, experimentally measured half-wave potentials indicated stronger prooxidant properties of quercetin derivatives as compared to Q. More expressive alterations of conformation in the transmembrane region of SERCA1 induced by quercetin derivatives, as compared with Q, may at least partially correlate with their higher lipophilicities. The protective effects of Q and MPQ on different isoforms of SERCA activity may be useful in prevention and treatment of inflammation or muscle diseases. The inhibitory effect of CHQ on SERCA isoforms may be beneficial in therapeutic approaches aimed at anti-tumor treatment. 相似文献
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Željko Jurjević Stephen W. Peterson Michele Solfrizzo Maja Peraica 《Mycotoxin Research》2013,29(3):141-145
Nine recently described Aspergillus species and four known species in section Versicolores were tested for their ability to produce sterigmatocystin on two liquid media, Czapek w/20 % Sucrose Broth and Yeast Extract Broth grown in the dark for 1 week at 25 °C. Detection and quantification of ST were performed by reversed-phase liquid chromatography coupled with electrospray ionization ion trap mass spectrometry. Limit of detection was 3 ng/mL and limit of quantification was 10 ng/mL. Nine newly described Aspergillus species from various substrates, A. amoenus, A. creber, A. cvjetkovicii, A. fructus, A. jensenii, A. puulaauensis, A. subversicolor, A. tennesseensis and A. venenatus in section Versicolores were found to produce sterigmatocystin. Production was confirmed in recently collected isolates of A. protuberus and A. versicolor. A. austroafricanus and A. tabacinus did not produce sterigmatocystin. 相似文献
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E. Sarantopoulou Z. Kollia A.C. Cefalas S. Kobe Z. SamardŽija 《Journal of biological physics》2003,29(2-3):149-158
In order to access the damaging mechanismsof DNA and its bases on themolecular level by T Hz radiation, it isnecessary to create a database of assessingdamage at different spectral regions.Possible damage by T Hz radiation will beassessed by comparison. Furthermore, theexpose of the cytosine to radiation at157 nm, suggest that photochemical bondbreaking is the only damaging mechanism inthe vacuum ultraviolet region of thespectrum, (157–170) nm where one photonbreaks one chemical bond. 相似文献
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Matej Ore?i? 《Disease models & mechanisms》2012,5(5):614-620
Primary obesity and psychotic disorders are similar with respect to the associated changes in energy balance and co-morbidities, including metabolic syndrome. Such similarities do not necessarily demonstrate causal links, but instead suggest that specific causes of and metabolic disturbances associated with obesity play a pathogenic role in the development of co-morbid disorders, potentially even before obesity develops. Metabolomics – the systematic study of metabolites, which are small molecules generated by the process of metabolism – has been important in elucidating the pathways underlying obesity-associated co-morbidities. This review covers how recent metabolomic studies have advanced biomarker discovery and the elucidation of mechanisms underlying obesity and its co-morbidities, with a specific focus on metabolic syndrome and psychotic disorders. The importance of identifying metabolic markers of disease-associated intermediate phenotypes – traits modulated but not encoded by the DNA sequence – is emphasized. Such markers would be applicable as diagnostic tools in a personalized healthcare setting and might also open up novel therapeutic avenues. 相似文献