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排序方式: 共有897条查询结果,搜索用时 15 毫秒
891.
892.
Hesam Shahabifard Mahdi Zarei Keihan Kookli Nazgol Esmalian Afyouni Narges Soltani Sairan Maghsoodi Ali Adili Javad Mahmoudi Navid Shomali Siamak Sandoghchian Shotorbani 《Biotechnology progress》2023,39(5):e3356
Genetically modified immune cells, especially CAR-T cells, have captured the attention of scientists over the past 10 years. In the fight against cancer, these cells have a special place. Treatment for hematological cancers, autoimmune disorders, and cancers must include CAR-T cell therapy. Determining the therapeutic targets, side effects, and use of CAR-T cells in neurological disorders, including cancer and neurodegenerative diseases, is the goal of this study. Due to advancements in genetic engineering, CAR-T cells have become crucial in treating some neurological disorders. CAR-T cells have demonstrated a positive role in treating neurological cancers like Glioblastoma and Neuroblastoma due to their ability to cross the blood–brain barrier and use diverse targets. However, CAR-T cell therapy for MS diseases is being researched and could be a potential treatment option. This study aimed to access the most recent studies and scientific articles in the field of CAR-T cells in neurological diseases and/or disorders. 相似文献
893.
Anooshe Kafash Shima Malakoutikhah Masoud Yousefi Farhad Ataei Hamid Heidari Eskandar Rastegar-Pouyani 《Zoology in the Middle East.》2018,64(1):47-54
The Gray Toad-headed Agama (Phrynocephalus scutellatus) occurs in Iran, Pakistan and Afghanistan and is represented in Iran by four distinctive genetic clades. We built distribution models for three of these clades (one clade was not included due to a low number of distribution records) using Maximum Entropy Algorithm in order to determine the contribution of ecological factors to the distribution pattern. The degree of spatial niche overlap between every pair of clades were measured using Schoener's D niche overlap metric. The results showed that at species-level climate variables (annual precipitation, annual mean temperature) were the most influential parameters determining the boundaries of the distribution in Iran. Temperature seasonality was found to be the most influential factor in the distribution of both Clade I and Clade II. However, this variable was replaced by the annual mean temperature for Clade VI. Based on the results of Schoener's D metric, Clades I and II had the lowest, and Clades II and VI the highest level of ecological niche overlap. Comparing the result of niche overlap with genetic distance between the clades, it was found that the ecologically least similar clades were those with the longer history of genetic segregation. 相似文献
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895.
Alsystin, a benzoylphenylurea derivative, was evaluated on Culex pipiens pipiens L. Treatment was made on newly third- and fourth-instar larvae for 24 h. Mortality occurred at various developmental stages following treatment. However, death as larvae was relatively important compared with the mortality recorded for the other later developmental stages. Treatment resulted in a dose-dependent reduction in adult emergence. Moreover, treatment caused morphological aberrations depending upon the importance of larval–adult transformation and significantly increased the duration of both third and fourth larval instars. A histological study conducted on fourth instar larval integument, revealed that Alsystin delayed the ecdysis and significantly reduced the thickness of both larval and pupal cuticles secreted compared with controls. Moreover, the apolysis that occurred at day 4 in controls was not affected by treatment. 相似文献
896.
Molecular Biology Reports - The elevated drug efflux by ABC transports has been considered the primary mechanism of drug resistance in cancer. Recently, non-coding RNAs, such as pseudogenes, have... 相似文献
897.
Docosahexaenoic acid reversed atherosclerotic changes in human endothelial cells induced by palmitic acid in vitro 下载免费PDF全文