全文获取类型
收费全文 | 880篇 |
免费 | 47篇 |
专业分类
927篇 |
出版年
2022年 | 12篇 |
2021年 | 19篇 |
2020年 | 10篇 |
2019年 | 10篇 |
2018年 | 18篇 |
2017年 | 6篇 |
2016年 | 28篇 |
2015年 | 26篇 |
2014年 | 35篇 |
2013年 | 67篇 |
2012年 | 83篇 |
2011年 | 72篇 |
2010年 | 34篇 |
2009年 | 34篇 |
2008年 | 56篇 |
2007年 | 55篇 |
2006年 | 56篇 |
2005年 | 48篇 |
2004年 | 54篇 |
2003年 | 45篇 |
2002年 | 51篇 |
2001年 | 6篇 |
1999年 | 6篇 |
1998年 | 9篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1994年 | 6篇 |
1993年 | 9篇 |
1992年 | 10篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 6篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有927条查询结果,搜索用时 0 毫秒
21.
Tanno M Sakamoto J Miura T Shimamoto K Horio Y 《The Journal of biological chemistry》2007,282(9):6823-6832
22.
Masaya Shimazaki Takehiro Sasaki Kouki Hikosaka Tohru Nakashizuka 《Global Change Biology》2011,17(11):3431-3438
Many studies have reported shifts in the altitudinal ranges of plant species in response to recent global warming. However, most studies of tree species have been conducted on a small scale and have focused on tree line ecotones by examining tree rings and age structure on account of the long life spans of the trees. To examine the impact of climate change on forest dynamics at a regional scale, we investigated differences in the population density and canopy height of a Japanese subalpine coniferous species, Abies mariesii, between 1967 and 2003 by analysis of high‐resolution aerial photographs of the Hakkoda Mountains, Honshu, Japan. In 712 plots within the photographs we analyzed which environmental variables (including elevation, aspect, wetness, and distance from moorlands) account for these changes. The population density of A. mariesii decreased below 1000 m a.s.l. and increased above 1300 m a.s.l. It also increased around moorlands, which may provide refugia at low elevations. The rate of increase in canopy height was lowest on the southeastern slopes and on the periphery of the moorlands. The distinct changes in the population density of A. mariesii at its distribution limits probably reflect the responses of the population to climatic changes during three decades. Areas surrounding the moorlands may offer refugia in spite of the poor growing conditions there. 相似文献
23.
Biosynthesis of α- and β-ionone, prominent scent compounds, in flowers of Osmanthus fragrans 总被引:1,自引:0,他引:1
Carotenoid derived volatiles are important fragrance compounds, which contribute to the scents of flowers from diverse taxa. A famous example is represented by the flowers of Osmanthus fragrans where apocarotenoids account for more than 20% of all volatiles. In the recent years, bio-degradation of carotenoids has been shown to be an important route for apocarotenoids formation. Here, we report on the contribution the O. fragrans carotenoid cleavage dioxygenase 1 to the synthesis of the two predominant C(13)-apocarotenoids, α- and β-ionone, derived from α-and β-carotene, respectively. 相似文献
24.
Kazuyuki Nakamura Hirofumi Kodera Tenpei Akita Masaaki Shiina Mitsuhiro Kato Hideki Hoshino Hiroshi Terashima Hitoshi Osaka Shinichi Nakamura Jun Tohyama Tatsuro Kumada Tomonori Furukawa Satomi Iwata Takashi Shiihara Masaya Kubota Satoko Miyatake Eriko Koshimizu Kiyomi Nishiyama Mitsuko Nakashima Yoshinori Tsurusaki Noriko Miyake Kiyoshi Hayasaka Kazuhiro Ogata Atsuo Fukuda Naomichi Matsumoto Hirotomo Saitsu 《American journal of human genetics》2013
25.
26.
Yuki Nakamura Fumiko Yukuhiro Masaya Matsumura Hiroaki Noda 《Applied Entomology and Zoology》2012,47(3):273-283
Cytoplasmic incompatibility (CI) is a reproductive phenotype induced by bacterial endosymbionts in arthropods. Measured as a reduction in egg hatchability resulting from the crossing of uninfected females with bacteria-infected males, CI increases the frequency of bacteria-infected hosts by restricting the fertilization opportunities of uninfected hosts in populations. Wolbachia, a type of alpha-proteobacteria, is well known as a CI inducer in a wide range of arthropod species, while Cardinium, a member of the phylum Bacteroidetes, is known to cause CI in one wasp and three spider mite species. In this study, dual infection with Cardinium and Wolbachia induced strong CI in a single host, Sogatella furcifera (Horváth), a planthopper species that is naturally infected with both bacteria. Specifically, infection with Cardinium alone was found to cause a 76 % reduction in egg development, and dual infection with Cardinium and Wolbachia a 96 % reduction, indicating that Cardinium induces CI and the dual infection raises the CI level. This study was the first to document reproductive alteration by Cardinium in a diploid host species. 相似文献
27.
28.
Asaki T Sugiyama Y Hamamoto T Higashioka M Umehara M Naito H Niwa T 《Bioorganic & medicinal chemistry letters》2006,16(5):1421-1425
A series of 3-substituted benzamide derivatives structurally related to STI-571 (imatinib mesylate), a Bcr-Abl tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML), was prepared and evaluated for antiproliferative activity against the Bcr-Abl-positive leukemia cell line K562. About ten 3-halogenated and 3-trifluoromethylated benzamide derivatives were identified as highly potent Bcr-Abl kinase inhibitors. One of these, NS-187 (9b), is a promising new candidate Bcr-Abl inhibitor for the therapy of STI-571-resistant chronic myeloid leukemia. 相似文献
29.
Curious low-temperature solubility of cellulose triacetates (CTA; here we use nominally "CTA," but the sample still contains 7% of C-6 position hydroxyls) in an organic solvent, methyl acetate (MA), was studied by a newly designed low-temperature type of DLS apparatus, which enabled for the first time to investigate the structural change of CTA in solution from 45 degrees C down to -100 degrees C. A molecularly dissolved CTA was found to coexist with three types of self-assemblies over all the temperature ranges except for the three specific temperatures T* of 30, -10, and -75 degrees C. However, these multiple self-assemblies are not in real thermodynamic equilibrium but in a metastable state, which could be stabilized effectively by the intermolecular hydrogen bonding (HB) with the help of the dipole interaction at low temperatures. In more detail, with decreasing temperature, these assemblies performed the structural reorganization drastically at three T*'s and would finally be frozen in a physical gel structure at -99 degrees C; around the freezing temperature of MA, CTA molecules could be trapped homogeneously in the frozen MA. The crucial role in such structural reorganizations is played by the balance between the intermolecular HB and the dipole interaction worked in the highly electronegative solvent. Because these interactions, which are mediated by the solvent electronegativity, change drastically with temperature, they result in the control of not only the single CTA chain conformation (= the intramolecular HB) but also the binding ways of the intermolecular HBs between CTA molecules and they induce multitudinous metastable structures in solution. Here it is noted that HB could work mainly between the C-6 position hydroxyls in the anhydroglucose units of CTA and are essentially effective at low temperatures. 相似文献
30.
Issei Tsukamoto Hiroyuki Koshio Masaya Orita Chikashi Saitoh Hiroko Yanai-Inamura Chika Kitada-Nozawa Eisaku Yamamoto Takeyuki Yatsu Shuichi Sakamoto Shin-ichi Tsukamoto 《Bioorganic & medicinal chemistry》2009,17(24):8161-8167
A series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives were optimized to achieve potent agonistic activity, both in vitro and in vivo, for the arginine vasopressin V2 receptor, resulting in the eventual discovery of compound 1g. Molecular modeling of compound 1g with V2 receptor was also examined to evaluate the binding mode of this series of compounds. 相似文献