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991.
Yushiro Take Yusaku Chikai Keiya Shimamori Masahiro Kuragano Hiroki Kurita Kiyotaka Tokuraku 《Biochemistry and Biophysics Reports》2022
Cerebral amyloid angiopathy (CAA) is a disease in which amyloid β (Aβ) is deposited on the walls of blood vessels in the brain, making those walls brittle and causing cerebral hemorrhage. However, the mechanism underlying its onset is not well understood. The aggregation and accumulation of Aβ cause the occlusion and fragility of blood vessels due to endothelial cell damage, breakdown of the blood-brain barrier, and replacement with elements constituting the blood vessel wall. In this study, we observed the effect of Aβ on human primary brain microvascular endothelial cells (hBMECs) in real-time using quantum dot nanoprobes to elucidate the mechanism of vascular weakening by Aβ. It was observed that Aβ began to aggregate around hBMECs after the start of incubation and that the cells were covered with aggregates. Aβ aggregates firmly anchored the cells on the plate surface, and eventually suppressed cell motility and caused cell death. Furthermore, Aβ aggregation induced the organization of abnormal actin, resulting in a significant increase in intracellular actin dots over 10 μm2. These results suggest that the mechanism by which Aβ forms a fragile vessel wall is as follows: Aβ aggregation around vascular endothelial cells anchors them to the substrate, induces abnormal actin organization, and leads to cell death. 相似文献
992.
Tomonori Hirao Atsushi Watanabe Manabu Kurita Teiji Kondo Katsuhiko Takata 《BMC plant biology》2008,8(1):70
Background
The recent determination of complete chloroplast (cp) genomic sequences of various plant species has enabled numerous comparative analyses as well as advances in plant and genome evolutionary studies. In angiosperms, the complete cp genome sequences of about 70 species have been determined, whereas those of only three gymnosperm species, Cycas taitungensis, Pinus thunbergii, and Pinus koraiensis have been established. The lack of information regarding the gene content and genomic structure of gymnosperm cp genomes may severely hamper further progress of plant and cp genome evolutionary studies. To address this need, we report here the complete nucleotide sequence of the cp genome of Cryptomeria japonica, the first in the Cupressaceae sensu lato of gymnosperms, and provide a comparative analysis of their gene content and genomic structure that illustrates the unique genomic features of gymnosperms. 相似文献993.
Takizawa Yusuke Nakamura Ryoka Kurita Takuro Nakajima Takanori 《Molecular biology reports》2022,49(9):8685-8692
Molecular Biology Reports - The unstirred water layer (UWL) is an integral part of the apical surface of mucosal epithelia and comprises mucins (MUC), for which there are many molecular species.... 相似文献
994.
Paris tetraphylla has a greater diversity of pollen exine sculpture than was previously thought. On the basis of 357 plants from 52 localities
of Japan, we distinguished seven sculpture types that are tentatively referred to here as G1, G2, G3, R1, R2, R3 and S. G1, G2 and G3 have gemmate sculpture in which the gemmae are characteristically large, medium and small in size, respectively; likewise,
R1, R2 and R3, have coarsely to finely ruglate sculpture; and S, scrobiculate sculpture. In general, any one of the seven types always
or predominantly occurs in each plant, thus allowing us to make comparisons among plants and further among local populations.
We thus found that G2 and G3, respectively, are the most and the second most widespread and occur in plants of 41 and 22 respectively, of the localities
examined, although their frequencies differ with locality. Generally R3 occurs in plants distributed at higher latitudes, while R2 is rather widespread and common to plants growing on high mountains. G1 and R1 are restricted to plants occurring south of Ibaraki Pref. and north of Gunma Pref., respectively. Such localized distributional
patterns of some types may reflect the reproductive nature and the history of geographical isolation inParis tetraphylla over the Japanese Islands. 相似文献