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91.
In leukemia cells, hyperthermia enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. The phenomenon is caspase-dependent and results in membrane changes leading to an increased recognition of TRAIL death receptors by TRAIL. Because either caspase-2 or an apical proteolytic event has been recently proposed to act as an initiator of the cell death mechanism induced by heat shock, we have investigated the hierarchy of caspase activation in cells exposed to the combined heat shock plus TRAIL treatment. We report here that caspases-2, -3, and -8 were the first caspases to be activated. As expected, caspase-8 is required and indispensable during the initiation of this death signaling. Caspase-2 may also participate in the phenomenon but, in contrast to caspase-8, its presence appears dispensable because its depletion by small interfering RNA is devoid of effects. Our observations also suggest a role of caspase-3 and of a particular cleaved form of this caspase during the early signals of heat shock plus TRAIL-induced apoptosis. 相似文献
92.
Pioz M Loison A Gauthier D Gibert P Jullien JM Artois M Gilot-Fromont E 《Oecologia》2008,155(4):691-704
Density-dependent and climatic factors affect reproduction and dynamics of wild ungulates. Parasites can also decrease reproductive
success through either a direct abortive effect or a negative impact on host growth and body condition. However, few studies
have investigated the effect of parasitism on fecundity of ungulates in natural conditions. We studied three bacterial infections
caused by Salmonella
enterica serovar Abortusovis, Chlamydophila abortus and Coxiella
burnetii. These bacteria are leading causes of reproductive failure in sheep, goat and cattle, which raises the question of their
influence on population dynamics of wild ungulates. A long-term study of demography and epidemiology of an alpine chamois
(Rupicapra rupicapra, L.) population (Les Bauges Reserve, France) and a generalized linear modeling approach were used to analyze the reproductive
success of chamois according to population density, weather conditions and the prevalence of antibodies against the three
bacteria in females. This approach enabled us to identify the confounding effect of weather and parasitism on fecundity in
a natural population. After accounting for density, the prevalence of antibodies against the three bacteria explained 36%
of the annual variation in reproductive success, and weather conditions explained an additional 31%. This study was, to our
knowledge, the first to compare the decrease in fecundity due to bacterial infections and weather conditions in a population
of wild mountain ungulates. 相似文献
93.
94.
Kezhi Yan Justine Rousseau Rebecca Okashah Littlejohn Courtney Kiss Anna Lehman Jill A. Rosenfeld Constance T.R. Stumpel Alexander P.A. Stegmann Laurie Robak Fernando Scaglia Thi Tuyet Mai Nguyen He Fu Norbert F. Ajeawung Maria Vittoria Camurri Lin Li Alice Gardham Bianca Panis Mohammed Almannai Xiang-Jiao Yang 《American journal of human genetics》2017,100(1):91-104
95.
96.
97.
L. Fki N. Bouaziz O. Chkir R. Benjemaa-Masmoudi A. Rival R. Swennen N. Drira B. Panis 《Biologia Plantarum》2013,57(2):375-379
Date palm (Phoenix dactylifera L.) cv. Khenizi caulogenic meristems were initiated from achlorophyllous leaves excised from in vitro shoot cultures and then proliferated on a specific culture medium supplemented with 70 g dm?3 sucrose. Regeneration rates obtained when using standard vitrification, droplet-vitrification, and encapsulation-vitrification protocols reached 26.7, 60.0, and 40.0 %, respectively. Only explants smaller than 3 mm in diameter were found to survive cryogenic treatments. Sucrose preculture, cold hardening and loading solution pretreatments showed significant effects on regeneration rates. Moreover, our results indicate that both sucrose preculture and cold acclimation of explants increased proline content. Cryopreservation of date palm tissue with high proliferation capacity can directly benefit large scale micropropagation projects. 相似文献
98.
The secondary response of human lymphocytes primed in vitro with allogeneic lymphocytes is reported. Accelerated proliferation is observed ' both against the specific priming cell and against unrelated third party cells, but the intensity of proliferation against the specific cell is usually, but not always, higher than that against third party cells. To clarify the respective roles ofHL-A andMLR-S in the development of this secondary proliferative response, three kinds of cells were used from which MLR-S activity was supposed to have been abolished while serologically-defined HL-A antigens were present: (a) heattreated cells, (b) UV-treated cells, and (c) a recombinant betweenHL-A andMLR-S. Heat treated cells were unsatisfactory for this study, but UV-treated and recombinant cells showed thatMLR-S was sufficient and necessary both for priming and for eliciting a secondary proliferative response. No role could be found forHL-A or for a secondMLR-S locus positioned between the first and secondHL-A loci. 相似文献
99.
Chen S Ji M Paris M Hullinger RL Andrisani OM 《The Journal of biological chemistry》2005,280(49):41025-41036
100.