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143.
Chukwudulue Uche Maryann Attah Alfred Francis Okoye Festus Basden Chiedu 《Phytochemistry Reviews》2022,21(5):1577-1604
Phytochemistry Reviews - The genus Psydrax is one of the ethno-medicinally important genera of the Rubiaceae family which has only received a limited scientific attention, despite coming from a... 相似文献
144.
Genomic DNA clones of human acid alpha glucosidase (GAA) and thymidine kinase (TK1) were used to map the exact location and order of these genes on human chromosome 17. Both genes were localized to the 17825-gter band (17825.2–825.3), with GAA distal to TK1. They were also shown to be, respectively, distal and proximal to an anonymous cosmid (cK17.71) previously mapped to this region. 相似文献
145.
Rohan H. C. Palmer Emma C. Johnson Hyejung Won Renato Polimanti Manav Kapoor Apurva Chitre Molly A. Bogue Chelsie E. Benca-Bachman Clarissa C. Parker Anurag Verma Timothy Reynolds Jason Ernst Michael Bray Soo Bin Kwon Dongbing Lai Bryan C. Quach Nathan C. Gaddis Laura Saba Hao Chen Michael Hawrylycz Shan Zhang Yuan Zhou Spencer Mahaffey Christian Fischer Sandra Sanchez-Roige Anita Bandrowski Qing Lu Li Shen Vivek Philip Joel Gelernter Laura J. Bierut Dana B. Hancock Howard J. Edenberg Eric O. Johnson Eric J. Nestler Peter B. Barr Pjotr Prins Desmond J. Smith Schahram Akbarian Thorgeir Thorgeirsson Dave Walton Erich Baker Daniel Jacobson Abraham A. Palmer Michael Miles Elissa J. Chesler Jake Emerson Arpana Agrawal Maryann Martone Robert W. Williams 《Genes, Brain & Behavior》2021,20(6):e12738
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration—particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs. 相似文献
146.
Evaluation of normalization procedures for oligonucleotide array data based on spiked cRNA controls
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Andrew A Hill Eugene L Brown Maryann Z Whitley Greg Tucker-Kellogg Craig P Hunter Donna K Slonim 《Genome biology》2001,2(12):research0055.1-research005513
Background
Affymetrix oligonucleotide arrays simultaneously measure the abundances of thousands of mRNAs in biological samples. Comparability of array results is necessary for the creation of large-scale gene expression databases. The standard strategy for normalizing oligonucleotide array readouts has practical drawbacks. We describe alternative normalization procedures for oligonucleotide arrays based on a common pool of known biotin-labeled cRNAs spiked into each hybridization. 相似文献147.
Gregory S. Whitt William F. Childers John Tranquilli Michael Champion 《Biochemical genetics》1973,8(1):55-72
Hybrid populations of sunfishes were produced in two different ponds, and the frequencies of allelic isozyme phenotypes were determined for three enzyme systems—malate dehydrogenase (NAD), esterases, and tetrazolium oxidase—in order to estimate the extent of heterozygosity at four different genetic loci. Interspecific F1 hybrid fry (red-ear male × bluegill female) were produced in vitro. These fry were stocked in ponds at the free-swimming stage. When 1 year old, the F1 hybrids produced a large F2 hybrid population. Successful hybrid reproduction occurred each year thereafter. In one pond, a 1-year-old F2 population exhibited all three isozyme phenotypes (red-ear, F1, bluegill) at most loci in the approximate ratio of the 1:2:1 expected. In a second pond, 5-year-old individuals of the F2 generation were morphologically like the F1 and were all heterozygous for the enzyme loci studied. This unusual degree of heterozygosity in the older F2 population appeared to be the result of differential survival of mature heterozygous individuals and not the result of early embryonic lethality. The increased heterozygosity at these unlinked loci was assumed to reflect the condition at other genetic loci in the F2 hybrids. Several possible mechanisms are advanced to explain this apparent heterosis.This research was supported by NSF grant GB-16425 (G.S.W.) and by funds from the Illinois Natural History Survey (W.F.C.). 相似文献
148.
Maryann S. Engster 《Journal of morphology》1976,150(1):183-211
As part of a study on trichopteran silk secretion, the histology, histochemistry, and ultrastructure of the silk glands of two species of limnephilid trichopteran larvae, Pycnopsyche guttifer (Walk.) and Neophylax concinnus McL., were investigated. The silk glands consist of three anatomically distinct regions: a long, posterior silk-secreting region; a shorter, anterior conducting tube; and a terminal press/common duct. In Pycnopsyche, there is also a modified bulbous region between the secreting and conducting areas. Each anatomical region has a distinct cell type. There are two structurally and histochemically different components of the secretion in the glandular lumen: a core and a peripheral layer. Both components are produced all along the gland and are principally proteinaceous. However, the peripheral layer is also PAS and alcian blue (pH. 2.5) positive and shows β-metachromasia with toluidine blue (pH 3.5), indicating the presence of both neutral and acidic polysaccharides. 相似文献