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21.
Two philometrid nematodes (Philometridae) are described from the marine perciform fish (tigertooth croaker) Otolithes ruber (Bloch & Schneider) (Sciaenidae) from off Iran: Clavinemoides annulatus n. g., n. sp. based on female specimens from the caudal fin of fish from the Persian Gulf and Philometra otolithi Moravec & Manoharan, 2013 from subgravid and nongravid females collected from the ovary of fishes in the Sea of Oman and the Persian Gulf. The monotypic genus Clavinemoides n. g. is mainly characterised by a triangular oral aperture, a markedly large anterior oesophageal bulb, a distinctly annulated body and numerous fine elevated transverse cuticular bands. The finding of P. otolithi in Iranian waters represents a new geographical record of this parasite species. An updated key to the genera of the Philometrinae Baylis & Daubney, 1926 is provided. 相似文献
22.
Mehdi Adib Fariba Peytam Reihaneh Shourgeshty Maryam Mohammadi-Khanaposhtani Mehdi Jahani Somaye Imanparast Mohammad Ali Faramarzi Bagher Larijani Ali Akbar Moghadamnia Ensieh Nasli Esfahani Fatemeh Bandarian Mohammad Mahdavi 《Bioorganic & medicinal chemistry letters》2019,29(5):713-718
Twenty three fused carbazole–imidazoles 6a–w were designed, synthesized, and screened as new α-glucosidase inhibitors. All the synthesized fused carbazole-imidazoles 6a-w were found to be more active than acarbose (IC50?=?750.0?±?1.5?µM) against yeast α-glucosidase with IC50 values in the range of 74.0?±?0.7–298.3?±?0.9?µM. Kinetic study of the most potent compound 6v demonstrated that this compound is a competitive inhibitor for α-glucosidase (Ki value?=?75?µM). Furthermore, the in silico studies of the most potent compounds 6v and 6o confirmed that these compounds interacted with the key residues in the active site of α-glucosidase. 相似文献
23.
High-risk types of human papillomaviruses (HPVs) are the etiological agents in nearly all cases (99.7%) of cervical cancer, and the HPV E6 protein is one of the two viral oncoproteins which is expressed in virtually all HPV-positive cancers. Therefore, classifying the risk type of HPVs is very useful and necessary for diagnosis and remedy of cervical cancer. To predict and to classify the risk types of HPV by bioinformatics analysis, 96 E6 protein sequences from available databases were obtained. To investigate the risk type of these sequences, PseAAC server, ROC curves and statistical analysis were applied. Our classification was based on some characters of HPV E6 proteins, such as hydrophobicity, hydrophilicity, side chain mass, PK of the α-COOH group, PK of the α-NH3+ group and PI at 25 °C. Risk type of 4 unknown HPV types and 25 non-reported HPV types were also predicted. These results show that bioinformatics based theoretical approaches can direct and simplify experimental studies. 相似文献
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S. P. Sharma A. Hirsch M. G. M. Hunink M. J. M. Cramer F. A. A. Mohamed Hoesein C. A. Geluk G. Kramer J. W. C. Gratama R. L. Braam P. M. van der Zee W. Yassi S. L. Wolters C. Gürlek G. Pundziute R. Vliegenthart R. P. J. Budde 《Netherlands heart journal》2023,31(2):52
BackgroundCoronary computed tomography angiography (CCTA) is widely used in the diagnostic work-up of patients with stable chest pain. CCTA has an excellent negative predictive value, but a moderate positive predictive value for detecting coronary stenosis. Computed tomography-derived fractional flow reserve (FFRct) is a non-invasive, well-validated technique that provides functional assessment of coronary stenosis, improving the positive predictive value of CCTA. However, to determine the value of FFRct in routine clinical practice, a pragmatic randomised, controlled trial (RCT) is required. We will conduct an RCT to investigate the impact of adding FFRct analysis in the diagnostic pathway of patients with a coronary stenosis on CCTA on the rate of unnecessary invasive coronary angiography, cost-effectiveness, quality of life and clinical outcome.MethodsThe FUSION trial is a prospective, multicentre RCT that will randomise 528 patients with stable chest pain and anatomical stenosis of ≥ 50% but < 90% in at least one coronary artery of ≥ 2 mm on CCTA, to FFRct-guided care or usual care in a 1:1 ratio. Follow-up will be 1 year. The primary endpoint is the rate of unnecessary invasive coronary angiography within 90 days.ConclusionThe FUSION trial will evaluate the use of FFRct in stable chest pain patients from the Dutch perspective. The trial is funded by the Dutch National Health Care Institute as part of the research programme ‘Potentially Promising Care’ and the results will be used to assess if FFRct reimbursement should be included in the standard health care package.Supplementary InformationThe online version of this article (10.1007/s12471-022-01711-w) contains supplementary material, which is available to authorized users. 相似文献
26.
Niloufar Abdollahian Hamideh Ghazizadeh Maryam MohammadiBajgiran Mehran Pashirzad Mahdiyeh Yaghooti Khorasani Mary Kathryn Bohn Shannon Steele Fatemeh Roudi Atieh Kamel Khodabandeh Sara Ghazi Zadeh Iman AlamiArani Seyede Negin Badakhshan Habibollah Esmaily Gordon A. Ferns Reza AssaranDarban Khosrow Adeli Majid GhayourMobarhan 《Journal of cellular and molecular medicine》2023,27(1):158
Age and sex need to be considered in the establishment of reference intervals (RIs), especially in early life when there are dynamic physiological changes. Since data for important biomarkers in healthy neonates and infants are limited, particularly in Iranian populations, we have determined age‐specific RIs for 7 laboratory biochemical parameters. This cross‐sectional study comprised a total of 344 paediatric participants (males: 158, females: 186) between the ages of 3 days and 30 months (mean age: 12.91 ± 7.15 months). Serum levels of creatinine, urea, uric acid, calcium, phosphate, vitamin D and high‐sensitivity C‐reactive protein (hs‐CRP) were measured using an Alpha classic‐AT plus auto‐analyser. We determined age‐specific RIs using CLSI Ep28‐A3 and C28‐A3 guidelines. No sex partitioning was required for any of the biomarkers. Age partitioning was required for kidney function tests and phosphate. The serum concentration of urea and creatinine increased with age, while phosphate and uric acid decreased with age. Age partitioning was not required for serum calcium, vitamin D, and hs‐CRP, which remained relatively constant throughout the age range. Age‐specific RIs for 7 routine biochemical markers were determined to address critical gaps in RIs in early life to help improve clinical interpretation of blood test results in young children, including neonates. Established age partitions demonstrate the biochemical changes that take place during child growth and development. These novel data will ultimately better disease management in the Iranian paediatric population and can be of value to clinical and hospital laboratories with similar populations. 相似文献
27.
Rasoul Ghasemi Leila Dargahi Ali Haeri Maryam Moosavi Zahurin Mohamed Abolhassan Ahmadiani 《Molecular neurobiology》2013,47(3):1045-1065
Arduous efforts have been made in the last three decades to elucidate the role of insulin in the brain. A growing number of evidences show that insulin is involved in several physiological function of the brain such as food intake and weight control, reproduction, learning and memory, neuromodulation and neuroprotection. In addition, it is now clear that insulin and insulin disturbances particularly diabetes mellitus may contribute or in some cases play the main role in development and progression of neurodegenerative and neuropsychiatric disorders. Focusing on the molecular mechanisms, this review summarizes the recent findings on the involvement of insulin dysfunction in neurological disorders like Alzheimer’s disease, Parkinson’s disease and Huntington’s disease and also mental disorders like depression and psychosis sharing features of neuroinflammation and neurodegeneration. 相似文献
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29.
Nazemian Maryam Hojati Vida Zavareh Saeed Madanchi Hamid Hashemi-Moghaddam Hamid 《International journal of peptide research and therapeutics》2020,26(1):259-269
International Journal of Peptide Research and Therapeutics - Chemotherapy using drug delivery systems can target tumor cells selectively and do not affect normal cells. In this paper, a specific... 相似文献
30.
Maryam Ghodrati Siahmazgi Mohammad Ali Nasiri Khalili Mehdi Zeinoddini Fathollah Ahmadpour Sirus Khodadadi 《International journal of peptide research and therapeutics》2020,26(2):767-774
Immunotoxin is a recombinant fusion toxin which has been developed to kill cancer cells selectively. DT389GCSF as a new immunotoxin consists of a truncated 相似文献