全文获取类型
收费全文 | 1370篇 |
免费 | 91篇 |
国内免费 | 4篇 |
专业分类
1465篇 |
出版年
2024年 | 4篇 |
2023年 | 27篇 |
2022年 | 60篇 |
2021年 | 97篇 |
2020年 | 91篇 |
2019年 | 166篇 |
2018年 | 98篇 |
2017年 | 78篇 |
2016年 | 82篇 |
2015年 | 72篇 |
2014年 | 87篇 |
2013年 | 123篇 |
2012年 | 108篇 |
2011年 | 88篇 |
2010年 | 57篇 |
2009年 | 50篇 |
2008年 | 45篇 |
2007年 | 18篇 |
2006年 | 26篇 |
2005年 | 20篇 |
2004年 | 20篇 |
2003年 | 19篇 |
2002年 | 16篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1992年 | 1篇 |
1988年 | 2篇 |
1985年 | 1篇 |
排序方式: 共有1465条查询结果,搜索用时 8 毫秒
131.
Mehmood Maryam Khan Muhammad Jadoon Khan Muhammad Jawad Akhtar Nadeem Mughal Fizza Shah Syed Tahir Abbas Hyder Muhammad Zeeshan Farrakh Sumaira Sadiq Irfan 《Molecular biology reports》2022,49(3):2059-2071
Molecular Biology Reports - Sesame is an ancient oilseed crop, known for its high oil content and quality. Its sensitivity to drought at early seedling stage is one of the limiting factors... 相似文献
132.
Daneshafrooz Afsoon Yuzbashian Emad Zarkesh Maryam Asghari Golaleh Mirmiran Parvin Hedayati Mehdi Abooshahab Raziyeh Fanaei S. Melika Khalaj Alireza 《Molecular biology reports》2022,49(1):163-169
Molecular Biology Reports - Adipose tissue (AT) is a passive reservoir for energy storage and an active endocrine organ responsible for synthesizing bioactive molecules called... 相似文献
133.
Aghamohamadi Elham Asri † Nastaran Odak Aylin Rostami-Nejad Mohammad Chaleshi Vahid Hajinabi Yasaman Eslami Maryam Mohammadian Haftcheshmeh Saeed Gholam-Mostafaei Fahimeh Sadat Asadzadeh-Aghdaei Hamid Masotti Andrea Zali Mohammad Reza 《Molecular biology reports》2022,49(7):6085-6091
Molecular Biology Reports - Celiac disease (CeD) and inflammatory bowel disease (IBD) are accompanied by impaired immune responses. To study the immune regulation of these diseases, we evaluated... 相似文献
134.
Jenabi Maryam Khodarahmi Parvin Tafvizi Farzaneh Bostanabad Saeed Zaker 《Molecular biology reports》2022,49(9):8413-8427
Molecular Biology Reports - The present study aimed to evaluate the expression of the chemokine CXCL8 in both mRNA and protein levels in the serum, follicular fluid (FF), and cumulus cells (CCs)... 相似文献
135.
Gharbi Dorra Mobayed Hassan M. Ali Ramzy Mohammed Tuffaha Amjad Dason Blessing Reena Ibrahim Tayseer Adeli Mehdi Sattar Hisham A. Trigo Maria del Mar Al-Nesf Maryam Ali 《Aerobiologia》2022,38(3):329-342
Aerobiologia - Daily monitoring of airborne fungal spores was carried out for the first time in Al Khor city, Qatar, using a Hirst type 7-day recording volumetric spore trap, from May 2017 to May... 相似文献
136.
Mohammadi Salman Shafiee Maryam Faraji Seyed Nooreddin Rezaeian Mohsen Ghaffarian-Bahraman Ali 《Biometals》2022,35(4):711-728
BioMetals - Breast milk is a complete food for the development of the newborn, but it can also be an important route for environmental pollutants transmission to the infants. This study was aimed... 相似文献
137.
138.
Muhammad Khan Amara Maryam Javed Iqbal Qazi Tonghui Ma 《International journal of biological sciences》2015,11(9):1100-1112
Cancer is the second leading cause of deaths worldwide. Despite concerted efforts to improve the current therapies, the prognosis of cancer remains dismal. Highly selective or specific blocking of only one of the signaling pathways has been associated with limited or sporadic responses. Using targeted agents to inhibit multiple signaling pathways has emerged as a new paradigm for anticancer treatment. Icariside II, a flavonol glycoside, is one of the major components of Traditional Chinese Medicine Herba epimedii and possesses multiple biological and pharmacological properties including anti-inflammatory, anti-osteoporosis, anti-oxidant, anti-aging, and anticancer activities. Recently, the anticancer activity of Icariside II has been extensively investigated. Here, in this review, our aim is to give our perspective on the current status of Icariside II, and discuss its natural sources, anticancer activity, molecular targets and the mechanisms of action with specific emphasis on apoptosis pathways which may help the further design and conduct of preclinical and clinical trials.Icariside II has been found to induce apoptosis in various human cancer cell lines of different origin by targeting multiple signaling pathways including STAT3, PI3K/AKT, MAPK/ERK, COX-2/PGE2 and β-Catenin which are frequently deregulated in cancers, suggesting that this collective activity rather than just a single effect may play an important role in developing Icariside II into a potential lead compound for anticancer therapy. This review suggests that Icariside II provides a novel opportunity for treatment of cancers, but additional investigations and clinical trials are still required to fully understand the mechanism of therapeutic effects to further validate it in anti-tumor therapy. 相似文献
139.
Milani P Gholamirad M Traas J Arnéodo A Boudaoud A Argoul F Hamant O 《The Plant journal : for cell and molecular biology》2011,67(6):1116-1123
Whereas the morphogenesis of developing organisms is relatively well understood at the molecular level, the contribution of the mechanical properties of the cells to shape changes remains largely unknown, mainly because of the lack of quantified biophysical parameters at cellular or subcellular resolution. Here we designed an atomic force microscopy approach to investigate the elastic modulus of the outer cell wall in living shoot apical meristems (SAMs). SAMs are highly organized structures that contain the plant stem cells, and generate all of the aerial organs of the plant. Building on modeling and experimental data, we designed a protocol that is able to measure very local properties, i.e. within 40-100 nm deep into the wall of living meristematic cells. We identified three levels of complexity at the meristem surface, with significant heterogeneity in stiffness at regional, cellular and even subcellular levels. Strikingly, we found that the outer cell wall was much stiffer at the tip of the meristem (5 ± 2 MPa on average), covering the stem cell pool, than on the flanks of the meristem (1.5 ± 0.7 MPa on average). Altogether, these results demonstrate the existence of a multiscale spatialization of the mechanical properties of the meristem surface, in addition to the previously established molecular and cytological zonation of the SAM, correlating with regional growth rate distribution. 相似文献
140.
Evidence for evolutionary constraints in <Emphasis Type="Italic">Drosophila</Emphasis> metal biology
Mutations in single Drosophila melanogaster genes can alter total body metal accumulation. We therefore asked whether evolutionary constraints maintain biologically
abundant metal ions (iron, copper, manganese and zinc) to similar concentrations in different species of Drosophilidae, or
whether metal homeostasis is a highly adaptable trait as shown previously for triglyceride and glycogen storage. To avoid
dietary influences, only species able to grow and reproduce on a standard laboratory medium were selected for analysis. Flame
atomic absorption spectrometry was used to determine metal content in 5-days-old adult flies. Overall, the data suggest that
the metallome of the nine species tested is well conserved. Meaningful average values for the Drosophilidae family are presented.
Few statistically significant differences were noted for copper, manganese and zinc between species. In contrast, Drosophila erecta and Drosophila virilis showed a 50% increase above average and a 30% decrease below average in iron concentrations, respectively. The changes in
total body iron content correlated with altered iron storage in intestinal ferritin stores of these species. Hence, the variability
in iron content could be accounted for by a corresponding adaptation in iron storage regulation. We suggest that the relative
expression of the multitude of metalloenzymes and other metal-binding proteins remains overall similar between species and
likely determines relative metal abundances in the organism. The availability of a complete and annotated genome sequence
of different Drosophila species presents opportunities to study the evolution of metal homeostasis in closely related organisms that have evolved
separately for millions or dozens of million years. 相似文献