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921.
Margherita Bertuzzi Markus Schrettl Laura Alcazar-Fuoli Timothy C. Cairns Alberto Mu?oz Louise A. Walker Susanne Herbst Maryam Safari Angela M. Cheverton Dan Chen Hong Liu Shinobu Saijo Natalie D. Fedorova Darius Armstrong-James Carol A. Munro Nick D. Read Scott G. Filler Eduardo A. Espeso William C. Nierman Hubertus Haas Elaine M. Bignell 《PLoS pathogens》2015,11(6)
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Hu P Kinyamu HK Wang L Martin J Archer TK Teng C 《The Journal of biological chemistry》2008,283(11):6752-6763
Estrogen-related receptor alpha (ERRalpha), a member of the nuclear receptor superfamily, is closely related to the estrogen receptors (ERalpha and ERbeta). The ERRalpha gene is estrogen-responsive in several mouse tissues and cell lines, and a multiple hormone-response element (MHRE) in the promoter is an important regulatory region for estrogen-induced ERRalpha gene expression. ERRalpha was recently shown to be a negative prognostic factor for breast cancer survival, with its expression being highest in cancer cells lacking functional ERalpha. The contribution of ERRalpha in breast cancer progression remains unknown but may have important clinical implications. In this study, we investigated ERRalpha gene expression and chromatin structural changes under the influence of 17beta-estradiol in both ER-positive MCF-7 and ER-negative SKBR3 breast cancer cells. We mapped the nucleosome positions of the ERRalpha promoter around the MHRE region and found that the MHRE resides within a single nucleosome. Local chromatin structure of the MHRE exhibited increased restriction enzyme hypersensitivity and enhanced histone H3 and H4 acetylation upon estrogen treatment. Interestingly, estrogen-induced chromatin structural changes could be repressed by estrogen antagonist ICI 182 780 in MCF-7 cells yet were enhanced in SKBR3 cells. We demonstrated, using chromatin immunoprecipitation assays, that 17beta-estradiol induces ERRalpha gene expression in MCF-7 cells through active recruitment of co-activators and release of co-repressors when ERRalpha and AP1 bind and ERalpha is tethered to the MHRE. We also found that this estrogen effect requires the MAPK signaling pathway in both cell lines. 相似文献
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Gholami Morteza Borhan Dayani Sepideh Mehrpooya Maryam Amoli Mahsa M. 《Molecular biology reports》2021,48(10):6665-6671
Molecular Biology Reports - Cardiovascular diseases (CVDs) are the most common and the first cause of death worldwide. While some studies have investigated the association of the Adenosine... 相似文献
927.
Behboodi Negin Farazestanian Marjaneh Rastgar-Moghadam Azam Mehramiz Mehrane Karimi Ehsan Rajabian Majid Rahmani Farzad Khorrami Shadi Jafarian Amirhosein Sharifi-Sistani Noorieh Ferns Gordon A. Avan Amir Hasanzadeh Malihe 《Molecular biology reports》2021,48(2):1433-1437
Molecular Biology Reports - Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the regulation of the immune system and potentially the progression of cervical... 相似文献
928.
Shateri Hossein Manafi Babak Tayebinia Heidar Karimi Jamshid Khodadadi Iraj 《Molecular biology reports》2021,48(2):1181-1191
Molecular Biology Reports - Atherosclerosis is the leading cause of death worldwide and has in part an inflammatory basis. Since epicardial adipose tissue (EAT) is in close contact with coronary... 相似文献
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Marjan Esmaeilzadeh Jalil Jaafari Ali Akbar Mohammadi Maryam Panahandeh Alahbakhsh Javid 《人类与生态风险评估》2019,25(5):1125-1136
To examine the level of contamination of Eshghabad region, Neyshabur, the concentration of heavy metals in soil was measured. For this purpose, 37 samples were taken from surface soil and the total concentration of heavy elements was measured by inductively coupled plasma (ICP). The mean concentration of Pb, Ni, Cu, Zn, and Fe was obtained to be 195, 87.3, 22.8, 274.8, and 2.5%, respectively. Using five valid indicators, the intensity of metal contamination in soil was calculated and compared. Furthermore, using statistical analyses, the relationships between the elements, their origins, and the spatial distribution of metals across various stations were investigated. The results indicated that the mean value of all of the studied metals (except for iron and copper) is greater than the mean concentration of metals in the Earth's crust. The indicators showed very high contamination for lead, while low to medium contamination for other elements of interest in the farming soils of the region. Statistical analyses indicated that there is a relatively similar contamination intensity across all of the studied stations. Considering the quality standards, the soils of this region are threatened by contamination of lead. 相似文献