Management of Citrus sinensis peels for protection and treatment against gastric ulcer induced by ethanol in rats

Abstract

Introduction: Stomach ulcer is one of the most prevalent disorders worldwide. The study was aimed to isolate and characterize the major polymethoxylated flavonoids in Citrus sinensis peels petroleum ether extract and investigate its protective and curative effect on gastric ulcer.

Material and methods: Some spectral analyses were used for identification of the isolated compounds from the petroleum ether extract of Citrus sinensis peels. One oral dose (0.5?ml/100?g b.wt.) of absolute ethanol was orally given to rats after starvation for 24?h to induce gastric ulcer. To explore the protective and curative role of the plant extract, it was orally (250?mg/kg b.wt.) given for 1 week either before or post-ulcer induction. A reference drug, ranitidine (100?mg/kg b.wt.), was also evaluated. Stomach acidity, gastric volume, lesion counts, glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), acid phosphatase (AP), interlukin-10 (IL-10) and prostaglandin E2 (PGE2) were estimated. Stomach histopathological features were monitored.

Results: Nine polymethoxy flavonoids were identified from the extract. Treatment with C. sinensis peels extract recorded amelioration in all parameters.

Conclusion: Citrus sinensis petroleum ether peels extract had protective and curative effects against gastric ulcer. Therefore, the extract recorded anti-secretory, anti-ulcerative, anti-inflammatory, and antioxidant effects. Its healing action exceeded its protective role due to its richness in polymethoxylated flavonoids     

Suit therapy versus whole-body vibration on bone mineral density in children with spastic diplegia

Objectives:Osteoporosis because of physical inactivity is one of the major complications associated with neuromuscular disorders. The study aimed to compare using Suit therapy and whole-body vibration in addition to selected physical therapy program to improve Bone Mineral Density in children with cerebral palsy of spastic diplegia.Methods:Forty-six patients were classified randomly into two equal groups. Patients in the group (A) engaged in a selected physical therapy program, also besides, suit therapy training program while those in the group (B) received the same selected physical therapy program received by group (A) in addition to the whole-body vibration training program. The treatment programs were conducted three times per week for twelve successive weeks. Measurements obtained included bone mineral density at the lumbar spine as well as at the femoral neck. These measures were recorded pre- and post-treatment.Results:There was a significant improvement in favor of the whole-body Vibration group. Bone mineral density improved significantly at both the lumbar spine (P=.038) and the femoral neck (P=.005) in the WBV group as compared to the Suit therapy group.Conclusions:Whole-body vibration is effective in improving Bone Mineral Density rather than Suit therapy in children with cerebral palsy of spastic diplegia.     

Clinical findings in an Arab boy with ring (14)(mos 46,XY,r(14)/45,XY,-14)

A five-month male Arab child with clinical features of ring(14) is reported. He had recurrent seizures and chest infections, microcephaly, elongated face, short palpebral fissures, broad nasal bridge, long philtrum, fish-like mouth with thin lips, micrognathia, low-set ears and retinal pigmentation with yellow-white spots on the maculae. In addition brachydactyly of fingers and toes, hypoplastic scrotum and mental deterioration were present.     

Evaluation of tolerance in Chrysoperla carnea Steph. (Neuropt., Chrysopidae) to successive insecticidal treatments

The results obtained indicate that the Chrysoperia carnea collected from Giza region (where no insecticidal treatments were used), were more sensitive to malathion than those of Kafr El-Sheikh, where insecticides were used intensively. In predator colonies which were treated repeatedly with malathion, the sensitivity to malathion decreased from the first to the fifth generation. On the other hand, insects of the reference colony, showed a considerable increase in sensitivity within the same generations.     

Role of serine protease inhibitor,ulinastatin, in rat model of hepatic encephalopathy: aquaporin 4 molecular targeting and therapeutic implication

Journal of Physiology and Biochemistry - Hepatic encephalopathy (HE) is a devastating neuropsychiatric presentation of the advanced hepatic insufficiency. It is associated with high morbidity and...     

Effect of incorporation of crop residues on development of diazotrophs and patterns of acetylene-reducing activity in Nile Valley soils

Summary Acetylene-reducing activity and populations of diazotrophs were estimated simultaneously in Giza soils after harvest of wheat and maize crops. Amendment of soil with residues of either crop together with flood irrigation enhanced the development of diazotrophs and nitrogenase activities in the soil. Bacterial numbers and acetylene-reducing activity decreased as soils dried following flood irrigation. Activities decreased progressively with each cycle of irrigation following the original incorporation of organic matter. Nitrogenase activity in the soil was greater in the cooler winter than in summer.