全文获取类型
收费全文 | 348篇 |
免费 | 27篇 |
国内免费 | 1篇 |
专业分类
376篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 9篇 |
2020年 | 6篇 |
2019年 | 3篇 |
2018年 | 16篇 |
2017年 | 7篇 |
2016年 | 19篇 |
2015年 | 20篇 |
2014年 | 21篇 |
2013年 | 27篇 |
2012年 | 28篇 |
2011年 | 32篇 |
2010年 | 23篇 |
2009年 | 13篇 |
2008年 | 26篇 |
2007年 | 13篇 |
2006年 | 8篇 |
2005年 | 16篇 |
2004年 | 8篇 |
2003年 | 12篇 |
2002年 | 7篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 4篇 |
1998年 | 9篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1993年 | 3篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有376条查询结果,搜索用时 0 毫秒
281.
Subrata K. Pore Anirban Ganguly Samaresh Sau Sudhakar Godeshala Anantha K. Kanugula Ramesh Ummanni Srigiridhar Kotamraju Rajkumar Banerjee 《Journal of cellular biochemistry》2020,121(1):804-815
Anticancer drugs exert their effects on cancer cells by deregulating many pathways linked to cell cycle, apoptosis, etc. but cancer cells gradually become resistive against anticancer drugs, thereby necessitating the development of newer generation anticancer molecules. N-end rule pathway has been shown to be involved in the degradation of many cell cycle and apoptosis-related proteins. However, the involvements of this pathway in cancer are not well established. Recently, we developed a non-peptide-based N-end rule pathway inhibitor, RF-C11 for type 1 and 2 recognition domains of E3 ubiquitin ligases. The inhibitor significantly increased the half-life of potential N-degrons leading to significant physiological changes in vivo. We hypothesized RF-C11 may be used to decipher the N-end rule pathway's role in cancer towards the development of anticancer therapeutics. In this study, we showed that RF-C11, barring noncancer cells, significantly sensitizes cancer cells towards different anticancer agents tested. We further find that the profound cellular sensitization to anticancer drugs was affected by (a) downregulation of X-linked inhibitor of apoptosis protein, an antiapoptotic protein and (b) by stabilization of RAD21, and thereby inhibiting metaphase to anaphase promotion. The study shows that RF-C11 or its analogs may be used as a novel additive in combination therapy against cancer. 相似文献
282.
Cancer is characterized by inter- and intra-tumor heterogeneity and this is also observed in the context of cancers caused by pathogens. Nearly 20% of all cancers are attributable to pathogenic organisms. Pathogenic infections result in deregulation of gene expression both by genetic and epigenetic mechanisms, thereby causing malignant transformation. Another characteristic of pathogen-induced cancers is the occurrence of chronic inflammation due to activation of the innate and adaptive arms of the immune system. This review focuses on the epigenetic changes induced by oncoviruses, parasites, cancer-causing bacteria and ‘endogenous pathogens’ to trigger host cell proliferation indefinitely as well as the inflammation associated with pathogen-induced cancers. The opportunity of targeting components of both pathogen and host epigenetic machinery to limit tumor progression is also discussed. 相似文献
283.
This paper describes an analysis of the plants of Sambalpur district of Orissa, India which have been used medicinally by local people. The families having medicinal values are analysed using Moerman's method of regression analysis. There were 136 plant families recorded from the study area. The analysis of families showed that the Euphorbiaceae family being used most ethnomedicinally by the local people in Sambalpur district of Orissa, whereas Poaceae is used least one. This type of study determines the degree of importance of plant families in the medicinal flora of the region. 相似文献
284.
T. Sudhakar Rao Michael E. Hogan Ganapathi R. Revankar 《Nucleosides, nucleotides & nucleic acids》2013,32(1-3):95-107
Abstract N7-Benzoyl-2′-deoxyformycin A (5) was prepared from formycin A and incorporated into the triple helix forming oligonucleotide PRE2ap at CG inversion sites. The modified oligonucleotide containing three substitutions of 2′-deoxyformycin A displayed a 10-fold increase in binding affinity as compared to its unmodified counterpart. This provided a method to accommodate CG inversion sites within target sites for antiparallel triple helix formation. 相似文献
285.
286.
287.
288.
289.
Peng Sun Shreeram C. Nallar Abhijit Raha Sudhakar Kalakonda Chidambaram N. Velalar Sekhar P. Reddy Dhananjaya V. Kalvakolanu 《The Journal of biological chemistry》2010,285(36):27545-27552
GRIM-19 (Gene associated with Retinoid-IFN-induced Mortality-19) was originally isolated as a growth suppressor in a genome-wide knockdown screen with antisense libraries. Like classical tumor suppressors, mutations, and/or loss of GRIM-19 expression occur in primary human tumors; and it is inactivated by viral gene products. Our search for potential GRIM-19-binding proteins, using mass spectrometry, that permit its antitumor actions led to the inhibitor of cyclin-dependent kinase 4, CDKN2A. The GRIM-19/CDKN2A synergistically suppressed cell cycle progression via inhibiting E2F1-driven gene expression. The N terminus of GRIM-19 and the fourth ankyrin repeat of CDKN2A are crucial for their interaction. The biological relevance of these interactions is underscored by observations that GRIM-19 promotes the inhibitory effect of CDKN2A on CDK4; and mutations from primary tumors disrupt its ability to interact with GRIM-19 and suppress E2F1-driven gene expression. 相似文献
290.
M. Thippeswamy P. Chandraobulreddy B. Sinilal M. Shiva Kumar Chinta Sudhakar 《Biologia Plantarum》2010,54(2):386-390
Proline (Pro) accumulation under water stress was measured in safflower (Carthamus tinctorius L.) drought tolerant cv. A1 and sensitive cv. Nira. Activities of pyrroline-5-carboxylate reductase (P5C reductase) and pyrroline-5-carboxylate
synthetase (P5C synthetase), two enzymes involved in the Pro biosynthetic pathway were also estimated. Water stress resulted
in a reduction in the leaf dry mass and chlorophyll content along with a gradual accumulation of Pro. RT-PCR results show
higher expression of Δ1-pyrroline-5-carboxylate synthetase (p5cs) gene in correlation with up-regulated Pro accumulation in cv. A1. P5C reductase was found to be the Pro synthesis rate limiting
whereas P5C synthetase did not show any specific response to the drought stress in both cultivars. 相似文献