Effect of an imidazobenzodiazepine (RO 15-1788) on aggressive behavior in mice

Imidazobenzodiazepine (Ro 15-1788, 5 mg/kg) similarly to a lose dose of apomorphine (0.1 mg/kg) decreased the intensity of footshock aggression in male rats. Ro 15-1788 significantly potentiated the antiaggressive action of apomorphine. Pirenperone (0.01 mg/kg) potentiated the effect of both drugs, whereas haloperidol (0.01 mg/kg) had an opposite action. After long-term treatment with apomorphine and Ro 15-1788 the tolerance to their antiaggressive action developed. This change was in agreement with increased serotonin metabolism in the forebrain. Unlike the action on aggressive behavior, Ro 15-1788 similarly to haloperidol (0.05 mg/kg) decreased the motor depressant effect of apomorphine (0.01 mg/kg) in mice. This effect correlated with the lowered serotonin metabolism after Ro 15-1788 administration. Unlike apomorphine, Ro 15-1788 reversed catalepsy induced by haloperidol (0.25 mg/kg). Administration of pirenperone (0.03 mg/kg) and destruction of serotoninergic terminals by p-chloroamphetamine (2 X 15 mg/kg) significantly potentiated the sedative action of apomorphine. It appears that different action of Ro 15-1788 on behavioral effects of apomorphine is related to different influence of Ro-1788 on serotoninergic processes in the striatum and limbic structures.     

Perch,Perca fluviatilis L., in Small Lakes: Relations between Population Characteristics and Lake Acidity

Perch population characteristics of small lakes were examined with a special reference to lakes which have acidified recently due to atmospheric deposition of air pollutants. The population density and biomass of perch were higher in an acid (pH 4.5) clear water lake with low aluminium concentration than in recently acidified (pH 4.3–4.7) clear water lakes with higher aluminium levels. The structure of perch population in an acid (pH 4.4) humic lake was similar to recently acidified clear water lakes. The population density and the biomass of perch were significantly higher in 6 lakes with pH>5.0 than in 6 lakes of pH<5.0 whereas the mean age and length at a given age were higher in the more acid lakes.     

Lipopolysaccharides of three classes of supersensitive mutants of Salmonella typhimurium

Abstract Cresyl violet acetate was found to be an appropriate redox-indicator dye in anaerobic culture media with low redox potentials. Low redox potentials ( E '_h−250 to −300 mV) in media were obtained by addition of dithiothreitol (DTT). DTT and cresyl violet acetate in media did not influence the total number of anaerobes cultured from human feces.