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71.
Oxygen concentration profiles have been measured, by means of with microelectrodes in sediments of Lake Baikal and Lake Malawi,
along transects allowing to give a survey of two major ancient Rift lakes: Lake Baikal (Eastern Siberia) and Lake Malawi (East
Africa), along depth transects in the constitutive basins of the lakes and/or of relevant depths with regard to oxygen (including
including the deepest point, 1680 m, in Lake Baikal). Sediment oxygen penetration depths (SOPs) display very different patterns,
depending on the lake in the two lakes. In Lake Baikal, SOPs are variable, show no significant relationship with bathymetric
depth and are surprisingly deep on Akademichesky ridge (> 50.0 mm), emphasizing the distinctive feature of this region in
the lake. While the Selenga river is an important source of eutrophication, the similarity of SOP-values in the Selenga shallow
with those of most other sites suggests either a dilution of organic material by allochthonous matter, or a strong south-to-north
transport of particles. In Lake Malawi, available oxygen is restricted to a maximum of three millimetres of the sediment,
and there is a negative relationship with bathymetric depth, as a result of a steady decline of oxygen concentration with
depth through the water column. Amongst the few parameters known to affect SOPs, the oxygen consumption by the sediment seems
the most significant in both lakes. SOP-values furthermore confirm differences in the trophic status of Baikal and Malawi,
respectively. The importance of oxygen as a factor likely to create ecological segregation for benthic organisms is discussed.
Lake Malawi offers possibilities of bathymetric segregation but no vertical segregation in the sediment. In contrast, no bathymetric
segregation related to oxygen is possible in Lake Baikal, but vertical segregation in the sediment is very likely.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
72.
Sander Martens Stefan M. Wierda Mathijs Dun Michal de Vries Henderikus G. O. M. Smid 《PloS one》2015,10(2)
BackgroundFormal musical training is known to have positive effects on attentional and executive functioning, processing speed, and working memory. Consequently, one may expect to find differences in the dynamics of temporal attention between musicians and non-musicians. Here we address the question whether that is indeed the case, and whether any beneficial effects of musical training on temporal attention are modality specific or generalize across sensory modalities.Conclusion/SignificanceAB magnitude within one modality can generalize to another modality, but this turns out not to be the case for every individual. Formal musical training seems to have a domain-general, but modality-specific beneficial effect on selective attention. The results fit with the idea that a major source of attentional restriction as reflected in the AB lies in modality-specific, independent sensory systems rather than a central amodal system. The findings demonstrate that individual differences in AB magnitude can provide important information about the modular structure of human cognition. 相似文献
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Abstract Myogenic contractions of the heart of the female blood-feeding insect, Rhodnius prolixus (Stål), are inhibited by crude extracts of testes applied directly to isolated dorsal vessels. Dorsal vessels were observed with a stereo microscope and heart beats timed with a stopwatch. In normal Rhodnius saline, hearts contract at 14.8 ± 7.1 beats per minute (n= 45). Crude extracts of the testes and the two male reproductive accessory organs (the opaque and transparent accessory glands) were prepared from previously frozen tissue by homogenizing 5–20 glands in a small glass homogenizer containing Rhodnius saline, centrifuging for 5 min at 2 000 g, and collecting the supernatant. Testes extract as low as 1.0 glands per mL inhibit contractions whereas crude extracts of the opaque or transparent accessory glands have no consistent effect. We refer to this cardiac inhibitor as rhodtestolin (Rhodnius testis inhibitory factor), and discuss its possible effects on the female during copulation. 相似文献
75.
Baart GJ Zomer B de Haan A van der Pol LA Beuvery EC Tramper J Martens DE 《Genome biology》2007,8(7):R136
Background
Neisseria meningitidis is a human pathogen that can infect diverse sites within the human host. The major diseases caused by N. meningitidis are responsible for death and disability, especially in young infants. In general, most of the recent work on N. meningitidis focuses on potential antigens and their functions, immunogenicity, and pathogenicity mechanisms. Very little work has been carried out on Neisseria primary metabolism over the past 25 years. 相似文献76.
Alicia Lammerts van Bueren Aakanksha Saraf Eric C. Martens Lubbert Dijkhuizen 《Applied and environmental microbiology》2015,81(12):3973-3983
Probiotic microorganisms are ingested as food or supplements and impart positive health benefits to consumers. Previous studies have indicated that probiotics transiently reside in the gastrointestinal tract and, in addition to modulating commensal species diversity, increase the expression of genes for carbohydrate metabolism in resident commensal bacterial species. In this study, it is demonstrated that the human gut commensal species Bacteroides thetaiotaomicron efficiently metabolizes fructan exopolysaccharide (EPS) synthesized by probiotic Lactobacillus reuteri strain 121 while only partially degrading reuteran and isomalto/malto-polysaccharide (IMMP) α-glucan EPS polymers. B. thetaiotaomicron metabolized these EPS molecules via the activation of enzymes and transport systems encoded by dedicated polysaccharide utilization loci specific for β-fructans and α-glucans. Reduced metabolism of reuteran and IMMP α-glucan EPS molecules may be due to reduced substrate binding by components of the starch utilization system (sus). This study reveals that microbial EPS substrates activate genes for carbohydrate metabolism in B. thetaiotaomicron and suggests that microbially derived carbohydrates provide a carbohydrate-rich reservoir for B. thetaiotaomicron nutrient acquisition in the gastrointestinal tract. 相似文献
77.
Ming‐Dong Zhang Amit Zeisel André Calas Marc Landry Matthew Fuszard Sally L Shirran Robert Schnell Árpád Dobolyi Márk Oláh Lauren Spence Jan Mulder Henrik Martens Miklós Palkovits Mathias Uhlen Harald H Sitte Catherine H Botting Ludwig Wagner Sten Linnarsson Tibor Harkany 《The EMBO journal》2015,34(1):36-54
78.
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80.
Christoph Ott Henrik Martens Imam Hassouna Bárbara Oliveira Christian Erck Maria-Patapia Zafeiriou Ulla-Kaisa Peteri D?rte Hesse Simone Gerhart Bekir Altas Tekla Kolbow Herbert Stadler Hiroshi Kawabe Wolfram-Hubertus Zimmermann Klaus-Armin Nave Walter Schulz-Schaeffer Olaf Jahn Hannelore Ehrenreich 《Molecular medicine (Cambridge, Mass.)》2015,21(1):803-815
Erythropoietin (EPO) exerts potent neuroprotective, neuroregenerative and procognitive functions. However, unequivocal demonstration of erythropoietin receptor (EPOR) expression in brain cells has remained difficult since previously available anti-EPOR antibodies (EPOR-AB) were unspecific. We report here a new, highly specific, polyclonal rabbit EPOR-AB directed against different epitopes in the cytoplasmic tail of human and murine EPOR and its characterization by mass spectrometric analysis of immuno-precipitated endogenous EPOR, Western blotting, immunostaining and flow cytometry. Among others, we applied genetic strategies including overexpression, Lentivirus-mediated conditional knockout of EpoR and tagged proteins, both on cultured cells and tissue sections, as well as intracortical implantation of EPOR-transduced cells to verify specificity. We show examples of EPOR expression in neurons, oligodendroglia, astrocytes and microglia. Employing this new EPOR-AB with double-labeling strategies, we demonstrate membrane expression of EPOR as well as its localization in intracellular compartments such as the Golgi apparatus. Moreover, we show injury-induced expression of EPOR. In mice, a stereotactically applied stab wound to the motor cortex leads to distinct EpoR expression by reactive GFAP-expressing cells in the lesion vicinity. In a patient suffering from epilepsy, neurons and oligodendrocytes of the hippocampus strongly express EPOR. To conclude, this new analytical tool will allow neuroscientists to pinpoint EPOR expression in cells of the nervous system and to better understand its role in healthy conditions, including brain development, as well as under pathological circumstances, such as upregulation upon distress and injury. 相似文献