排序方式: 共有107条查询结果,搜索用时 171 毫秒
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Tatsiana Aneichyk William T. Hendriks Rachita Yadav David Shin Dadi Gao Christine A. Vaine Ryan L. Collins Aloysius Domingo Benjamin Currall Alexei Stortchevoi Trisha Multhaupt-Buell Ellen B. Penney Lilian Cruz Jyotsna Dhakal Harrison Brand Carrie Hanscom Caroline Antolik Marisela Dy Michael E. Talkowski 《Cell》2018,172(5):897-909.e21
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Manuel Alejandro Cruz-Aguilar Enrique Hernández-Arteaga Marisela Hernández-González Ignacio Ramírez-Salado Miguel Angel Guevara 《American journal of primatology》2020,82(8):e23162
The study of electroencephalographic (EEG) activity during sleep in the spider monkey has provided new insights into primitive arboreal sleep physiology and behavior in anthropoids. Nevertheless, studies conducted to date have maintained the frequency ranges of the EEG bands commonly used with humans. The aim of the present work was to determine the EEG broad bands that characterize sleep and wakefulness in the spider monkey using principal component analysis (PCA). The EEG activity was recorded from the occipital, central, and frontal EEG derivations of six young-adult male spider monkeys housed in a laboratory setting. To determine which frequencies covaried and which were orthogonally independent during sleep and wakefulness, the power EEG spectra and interhemispheric and intrahemispheric EEG correlations from 1 to 30 Hz were subjected to PCA. Findings show that the EEG bands detection differed from those reported previously in both spider monkeys and humans, and that the 1–3 and 2–13 Hz frequency ranges concur with the oscillatory activity elucidated by cellular recordings of subcortical regions. Results show that applying PCA to the EEG spectrum during sleep and wakefulness in the spider monkey led to the identification of frequencies that covaried with, and were orthogonally independent of, other frequencies in each behavioral vigilance state. The new EEG bands differ from those used previously with both spider monkeys and humans. The 1–3 and 2–13 Hz frequency ranges are in accordance with the oscillatory activity elucidated by cellular recordings of subcortical regions in other mammals. 相似文献
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Agnès Fleury Armando Trejo Humberto Cisneros Roberto García-Navarrete Nelly Villalobos Marisela Hernández Juana Villeda Hernández Beatriz Hernández Gabriela Rosas Raul J. Bobes Aline S. de Aluja Edda Sciutto Gladis Fragoso 《PLoS neglected tropical diseases》2015,9(8)
Human neurocysticercosis (NC) is caused by the establishment of Taenia solium larvae in the central nervous system. NC is a severe disease still affecting the population in developing countries of Latin America, Asia, and Africa. While great improvements have been made on NC diagnosis, treatment, and prevention, the management of patients affected by extraparenchymal parasites remains a challenge. The development of a T. solium NC experimental model in pigs that will allow the evaluation of new therapeutic alternatives is herein presented. Activated oncospheres (either 500 or 1000) were surgically implanted in the cerebral subarachnoid space of piglets. The clinical status and the level of serum antibodies in the animals were evaluated for a 4-month period after implantation. The animals were sacrificed, cysticerci were counted during necropsy, and both the macroscopic and microscopic characteristics of cysts were described. Based on the number of established cysticerci, infection efficiency ranged from 3.6% (1000 oncospheres) to 5.4% (500 oncospheres). Most parasites were caseous or calcified (38/63, 60.3%) and were surrounded by an exacerbated inflammatory response with lymphocyte infiltration and increased inflammatory markers. The infection elicited specific antibodies but no neurological signs. This novel experimental model of NC provides a useful tool to evaluate new cysticidal and anti-inflammatory approaches and it should improve the management of severe NC patients, refractory to the current treatments. 相似文献
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Sobern-Chvez Gloria Aguirre-Ramrez Marisela Snchez Rosalba 《Journal of industrial microbiology & biotechnology》2005,32(11):675-677
Pseudomonas aeruginosa produces the biosurfactant rhamnolipid, which has several potential biotechnological applications. The synthesis of this surfactant is catalyzed by rhamnosyltransferase 1, composed of the proteins RhlA and RhlB. Here we report that RhlA plays a role not only in surfactant synthesis, but also in the production of polyhydroxyalkanoates, polymers that can be used for the synthesis of biodegradable plastics.
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Marisela R. Rodriguez Alyssa Lundgren Pearl Sabastian Qian Li Gary Churchill Michael G. Brown 《Mammalian genome》2009,20(7):414-423
NK cell-mediated resistance to viruses is subject to genetic control in humans and mice. Here we used classical and quantitative
genetic strategies to examine NK-mediated murine cytomegalovirus (MCMV) control in genealogically related New Zealand white
(NZW) and black (NZB) mice. NZW mice display NK cell-dependent MCMV resistance while NZB NK cells fail to limit viral replication
after infection. Unlike Ly49H+ NK resistance in C57BL/6 mice, NZW NK-mediated MCMV control was Ly49H-independent. Instead, MCMV resistance in NZW (Cmv2) involves multiple genetic factors. To establish the genetic basis of Cmv2 resistance, we further characterized a major chromosome X-linked resistance locus (DXMit216) responsible for innate MCMV control in NZW × NZB crosses. We found that the DXMit216 locus affects early MCMV control in New Zealand F2 crosses and demonstrate that the NZB-derived DXMit216 allele enhances viral resistance in F2 males. The evolutionary conservation of the DXMit216 region in mice and humans suggests that a Cmv2-related mechanism may affect human antiviral responses.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献