全文获取类型
收费全文 | 7414篇 |
免费 | 511篇 |
国内免费 | 2篇 |
出版年
2023年 | 38篇 |
2022年 | 80篇 |
2021年 | 158篇 |
2020年 | 84篇 |
2019年 | 128篇 |
2018年 | 147篇 |
2017年 | 136篇 |
2016年 | 236篇 |
2015年 | 349篇 |
2014年 | 394篇 |
2013年 | 508篇 |
2012年 | 578篇 |
2011年 | 571篇 |
2010年 | 403篇 |
2009年 | 309篇 |
2008年 | 437篇 |
2007年 | 431篇 |
2006年 | 455篇 |
2005年 | 387篇 |
2004年 | 387篇 |
2003年 | 345篇 |
2002年 | 325篇 |
2001年 | 74篇 |
2000年 | 47篇 |
1999年 | 71篇 |
1998年 | 73篇 |
1997年 | 81篇 |
1996年 | 59篇 |
1995年 | 36篇 |
1994年 | 47篇 |
1993年 | 39篇 |
1992年 | 33篇 |
1991年 | 31篇 |
1990年 | 27篇 |
1989年 | 28篇 |
1988年 | 27篇 |
1987年 | 21篇 |
1986年 | 22篇 |
1985年 | 30篇 |
1984年 | 29篇 |
1983年 | 24篇 |
1982年 | 35篇 |
1981年 | 29篇 |
1980年 | 25篇 |
1979年 | 16篇 |
1977年 | 16篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1974年 | 11篇 |
1973年 | 18篇 |
排序方式: 共有7927条查询结果,搜索用时 15 毫秒
151.
152.
David G. Behm Ashley Peach Meaghan Maddigan Saied Jalal Aboodarda Mario C. DiSanto Duane C. Button Nicola A. Maffiuletti 《Journal of electromyography and kinesiology》2013,23(5):1215-1221
Both stretching and massage can increase range of motion. Whereas the stretching-induced increases in ROM have been attributed to changes in neural and muscle responses, there is no literature investigating the ROM mechanisms underlying the interaction of stretch and massage. The objective of this paper was to evaluate changes in neural and evoked muscle responses with two types of massage and static stretching. With this repeated measures design, 30 s of plantar flexors musculotendinous junction (MTJ) and tapotement (TAP) massage were implemented either with or without 1 min of concurrent stretching as well as a control condition. Measures included the soleus maximum H-reflex/M-wave (H/M) ratio, as well as electromechanical delay (EMD), and evoked contractile properties of the triceps surae. With the exception of EMD, massage and stretch did not significantly alter triceps surae evoked contractile properties. Massage with and without stretching decreased the soleus H/M ratio. Both TAP conditions provided greater H/M ratio depression than MTJ massage while the addition of stretch provided the greatest inhibition. Both massage types when combined with stretching increased the duration of the EMD. In conclusion, MTJ and TAP massage as well as stretching decreased spinal reflex excitability, with TAP providing the strongest suppression. While static stretching prolongs EMD, massage did not affect contractile properties. 相似文献
153.
154.
Abstract A strong K+-dependent, fusicoccin-sensitive increase in acidic extrusion paralleled by a corresponding increase in net K+ uptake and hyperpolarization of transmembrane electrical potential was observed in the root segments of wheat seedlings cultured in diluite CaSO4+0.27 mM Methyl-acethydroxamoilacetate. Moreover, K+-induced depolarization was also increased up to three times. 相似文献
155.
Laura Pancaro Mario Innamorati Ornella Vergnano Gambi Silvia Occhiochiuso 《Plant biosystems》2013,147(6):265-284
Abstract Cobalt, nickel and chromium effects on germination of Alyssum, during after-ripening and aging. Cobalt (2.5–20mM), nickel (2.5–25mM) and chromium (0.2-1mM) effects have been studied in seeds of three species of Alyssum, of which two, A. bertolonii and A. argenteum, endemics to serpentine soils and one, A. nebrodense, closely related to the others but endemic to the Madonie (Sicily) where it grows on limestone. The results, expressed as percentage of germinated seeds (p), Kotowski coefficient of velocity (v) and germination average ratio (pτ), have been subjected to statistical analysis. The effect per mM is generally inhibitory, not significant for cobalt, weak but significant for nickel, more marked and significant for chromium, linearly correlated to concentration. The inhibition reaches its highest level when seeds are ripe, being significantly related to the control germination capacity (pτ). The values of the specific inhibition (effect/mM modditppτ) for all the three species are higher for chromium, which is more toxic than nickel, and increase from A. nebrodense to A. argenteum, showing that of the two serpentine endemics A. bertolonii is more tolerant both to nickel and chromium. 相似文献
156.
Silvia Leoncini Viviana Rossi Cinzia Signorini Italo Tanganelli Mario Comporti 《Free radical research》2013,47(8):716-724
Increased oxidative stress and decreased life span of erythrocytes (RBCs) are repeatedly reported in diabetes. In the aim to elucidate the mechanism of the latter, i.e. the events leading to erythrocyte ageing, this study determined in RBCs from diabetic patients iron release in a free desferrioxamine-chelatable form (DCI), methemoglobin (MetHb) formation, binding of autologous IgG to membrane proteins and in plasma non-protein-bound iron (NPBI), F2-Isoprostanes (F2-IsoPs) and advanced oxidation protein products (AOPP). DCI and MetHb were higher in diabetic RBCs than in controls and autologous IgG binding occurred in a much higher percentage of diabetic patients than controls. A significant correlation between DCI and IgG binding was found in diabetic RBCs. Plasma NPBI, esterified F2-IsoPs and AOPP were higher in diabetic patients and a significant correlation was found between plasma NPBI and intra-erythrocyte DCI. The increased DCI and autologous IgG binding appear to be important factors in the accelerated removal of RBCs from the blood stream in diabetes and the increase in plasma NPBI could play an important role in the increased oxidative stress. 相似文献
157.
158.
José Correa-Basurto Judith Espinosa-Raya Mario González-May L. Michel Espinoza-Fonseca Iván Vázquez-Alcántara José Trujillo-Ferrara 《Journal of enzyme inhibition and medicinal chemistry》2013,28(2):133-138
Two arylderivatives, 3a-Acetoxy-5H-pyrrolo(1,2-a) (3,1)benzoxazin-1,5-(3aH)-dione 3 and cis-N-p-Acetoxy-phenylisomaleimide 4, were synthesized from anthranilic acid and para-aminophenol, respectively. The inhibitory effects of these compounds on acetylcholinesterase (AChE) activity were evaluated in vitro as well as by docking simulations. Both compounds showed inhibition of AChE activity (Ki = 4.72 ± 2.3 μM for 3 and 3.6 ± 1.8 μM for 4) in in vitro studies. Moreover, they behaved as irreversible inhibitors and made π–π interaction with W84 and hydrogen bonded with S200 and Y337 according to experimental data and docking calculations. The docking calculations showed ΔG bind (kcal/mol) of ? 9.22 for 3 and ? 8.58 for 4. These two compounds that can be use as leads for a new family of anti-Alzheimer disease drugs. 相似文献
159.
David A Martin Melvin Churchill Luis Felipe Flores-Suarez Mario H Cardiel Daniel Wallace Richard Martin Kristine Phillips Jeffrey L Kaine Hua Dong David Salinger Erin Stevens Chris B Russell James B Chung 《Arthritis research & therapy》2013,15(5):R164
Introduction
The aim of this study was to evaluate the safety, pharmacokinetics, and clinical response of brodalumab (AMG 827), a human, anti-IL-17 receptor A (IL-17RA) monoclonal antibody in subjects with moderate-to-severe rheumatoid arthritis (RA).Methods
This phase Ib, randomized, placebo-controlled, double-blind multiple ascending dose study enrolled subjects with moderate to severe RA (≥6/66 swollen and ≥8/68 tender joints). Subjects were randomized 3:1 to receive brodalumab (50 mg, 140 mg, or 210 mg subcutaneously every two weeks for 6 doses per group; or 420 mg or 700 mg intravenously every 4 weeks for two doses per group) or placebo. Endpoints included incidence of adverse events (AEs) and pharmacokinetics. Exploratory endpoints included pharmacodynamics, and improvements in RA clinical metrics.Results
Forty subjects were randomized to investigational product; one subject discontinued due to worsening of RA (placebo). The study was not designed to assess efficacy. AEs were reported by 70% (7/10) of placebo subjects and 77% (22/30) of brodalumab subjects. Three serious AEs were reported in two subjects; there were no opportunistic infections. Brodalumab treatment resulted in inhibition of IL-17 receptor signaling and receptor occupancy on circulating leukocytes. No treatment effects were observed with individual measures of RA disease activity. On day 85 (week 13) 37% (11/30) of brodalumab subjects and 22% (2/9) of placebo subjects achieved ACR20; 7% (2/30) brodalumab subjects and 11% (1/9) of placebo subjects achieved ACR50; and 0% (0/30) brodalumab subjects and 0% (0/9) of placebo subjects achieved ACR70.Conclusions
Multiple dose administration of brodalumab was tolerated in subjects with active RA. There was no evidence of a clinical response to brodalumab in subjects with RA.Trial registration
ClinicalTrials.gov, NCT00771030相似文献160.
Mario Rotondi Francesca Coperchini Luca Chiovato 《Cytokine & growth factor reviews》2013,24(6):539-546
CXCL8 was the first chemokine shown to be secreted by thyrocytes. Experimental data suggest that CXCL8 plays a role in thyroid homeostasis but its role in thyroid diseases remains poorly investigated. Clinical studies measuring the serum levels of CXCL8 in patients with autoimmune-thyroid-diseases reported conflicting results. Solid evidences support a role of CXCL8 as a tumor-promoting agent in several human cancers. Studies in thyroid cancer are still in their initial stage, but promising. Several evidences indicate that thyroid cancer may share with other human malignancies some of the effects of CXCL8 and highlight the possibility of using CXCL8 as a marker of aggressiveness. Basic and clinical evidences in favor or against a role for CXCL8 in thyroid diseases are discussed. 相似文献