全文获取类型
收费全文 | 149篇 |
免费 | 7篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2019年 | 2篇 |
2015年 | 9篇 |
2014年 | 4篇 |
2013年 | 13篇 |
2012年 | 6篇 |
2011年 | 20篇 |
2010年 | 11篇 |
2009年 | 3篇 |
2008年 | 11篇 |
2007年 | 12篇 |
2006年 | 12篇 |
2005年 | 6篇 |
2004年 | 11篇 |
2003年 | 11篇 |
2002年 | 7篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1982年 | 3篇 |
1978年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有156条查询结果,搜索用时 15 毫秒
31.
Susanne Homma Andrea Horsch Marie-Noëlle Pouch Franck Petit Yves Briand Hans-Peter Schmid 《Molecular biology reports》1994,20(2):57-61
Proteasomes (prosomes) are large multiprotein complexes. They are involved in protein degradation of ubiquitin-conjugated proteins and in the generation of MHC class I peptides. We gave further evidence that they interfere within vitro protein synthesis. Proteasomes inhibit the translation of Tobacco mosaic virus RNA. Analysis of cell-free systems by sucrose gradient centrifugation revealted that they prevent the formation of 80S initiation complexes but not the early phase of initiation. 相似文献
32.
33.
Silvio Gianinazzi Armelle Gollotte Marie-Noëlle Binet Diederik van Tuinen Dirk Redecker Daniel Wipf 《Mycorrhiza》2010,20(8):519-530
The beneficial effects of arbuscular mycorrhizal (AM) fungi on plant performance and soil health are essential for the sustainable
management of agricultural ecosystems. Nevertheless, since the ‘first green revolution’, less attention has been given to
beneficial soil microorganisms in general and to AM fungi in particular. Human society benefits from a multitude of resources
and processes from natural and managed ecosystems, to which AM make a crucial contribution. These resources and processes,
which are called ecosystem services, include products like food and processes like nutrient transfer. Many people have been
under the illusion that these ecosystem services are free, invulnerable and infinitely available; taken for granted as public
benefits, they lack a formal market and are traditionally absent from society’s balance sheet. In 1997, a team of researchers
from the USA, Argentina and the Netherlands put an average price tag of US $33 trillion a year on these fundamental ecosystem
services. The present review highlights the key role that the AM symbiosis can play as an ecosystem service provider to guarantee
plant productivity and quality in emerging systems of sustainable agriculture. The appropriate management of ecosystem services
rendered by AM will impact on natural resource conservation and utilisation with an obvious net gain for human society. 相似文献
34.
35.
El Hadri K Glorian M Monsempes C Dieudonné MN Pecquery R Giudicelli Y Andreani M Dugail I Fève B 《The Journal of biological chemistry》2004,279(15):15130-15141
36.
37.
Replacement of murine leukemia virus readthrough mechanism by human immunodeficiency virus frameshift allows synthesis of viral proteins and virus replication 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Retroviruses use unusual recoding strategies to synthesize the Gag-Pol polyprotein precursor of viral enzymes. In human immunodeficiency virus, ribosomes translating full-length viral RNA can shift back by 1 nucleotide at a specific site defined by the presence of both a slippery sequence and a downstream stimulatory element made of an extensive secondary structure. This so-called frameshift mechanism could become a target for the development of novel antiviral strategies. A different recoding strategy is used by other retroviruses, such as murine leukemia viruses, to synthesize the Gag-Pol precursor; in this case, a stop codon is suppressed in a readthrough process, again due to the presence of a specific structure adopted by the mRNA. Development of antiframeshift agents will greatly benefit from the availability of a simple animal and virus model. For this purpose, the murine leukemia virus readthrough region was rendered inactive by mutagenesis and the frameshift region of human immunodeficiency virus was inserted to generate a chimeric provirus. This substitution of readthrough by frameshift allows the synthesis of viral proteins, and the chimeric provirus sequence was found to generate infectious viruses. This system could be a most interesting alternative to study ribosomal frameshift in the context of a virus amenable to the use of a simple animal model. 相似文献
38.
Three new triterpenes, synthesized by a Bolivian strain of the green microalga Botryococcus braunii, were isolated and their chemical structures determined by 1D and 2D NMR, and mass spectrometry. These compounds are tri-, di-, and mono-methylsqualenes, co-occurring with the previously identified tetramethylsqualene and some C(30)-C(32) botryococcenes. In this strain, methylated squalenes constitute up to 24% of the total hydrocarbons and 4.5% of the dry biomass. The results of a pulse-chase experiment with L-[Me-(13)C] methionine provide evidence for the origin of these compounds via methylation of squalene at positions 3, 7, 18 and 22. 相似文献
39.