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31.
Lue d'Auriol Marie-Geneviève Mattei Catherine Andre Francis Galibert 《Human genetics》1988,78(4):374-376
Summary Using a 166-nucleotide-long DNA synthetic probe corresponding to the v-kit sequence (1458-1623), we have mapped the human c-kit gene to chromosome 4 at the q11–q12 band by in situ hybridization on chromosomes from human lymphocyte preparations. 相似文献
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Hemostasis imbalance in experimental hypertension 总被引:4,自引:0,他引:4
Corseaux D Ollivier V Fontaine V Huisse MG Philippe M Louedec L Vranckx R Ravanat C Lanza F Angles-Cano E Guillin MC Michel JB 《Molecular medicine (Cambridge, Mass.)》2002,8(4):169-178
BACKGROUND: The rat model of chronic intoxication by N(G) -nitro-L-arginine methyl ester (L-NAME) induces severe systemic arterial hypertension and progressive ischemic lesions in the central nervous system and kidneys. We investigated the possible molecular basis of these thrombotic events. METHODS AND RESULTS: Administration of L-NAME increased plasma markers of thrombin generation, thrombin-antithrombin complexes, and soluble glycoprotein V, measured by specific ELISA. Thrombin generation in vivo was associated with ex vivo platelet desensitization to adenosine 5'-diphosphate and collagen-induced aggregation. In the aortic layers and renal arterioles, tissue factor mRNA (semi-quantitative RT-PCR) and activity (coagulation assay) were increased. In contrast, tissue factor activity was not modified in glomeruli. In parallel, an impairment of the fibrinolytic system was demonstrated by an increase in plasma levels and arterial secretion of plasminogen activator inhibitor-1. In the arterial wall, plasminogen activator inhibtor-1 mRNA was significantly increased. Moreover, antifibrinolytic activity, studied by fibrin reverse zymography, was increased whereas all tissue-plasminogen activator activity secreted by the hypertensive arterial wall was detected as complexes with its specific inhibitor. In animals treated with the angiotensin-converting enzyme (ACE) inhibitor Zofenil, all of these parameters remained at control levels. CONCLUSIONS: These results indicate that chronic blockade of nitric oxide production in rats results in enhancement of blood markers of thrombin generation associated with tissue factor induction and impairment of fibrinolysis in the vascular wall, which may contribute to the thrombotic complications associated with hypertension. 相似文献
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Sylvie Grandemange Sophie Schaller Shigeru Yamano Stanislas Du Manoir George V Shpakovski Marie-Geneviève Mattei Claude Kedinger Marc Vigneron 《BMC molecular biology》2001,2(1):14
Background
The sequences encoding the yeast RNA polymerase II (RPB) subunits are single copy genes. 相似文献37.
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Perrine Malzac Marie-Geneviève Mattei Jean Thibault Gilles Bruneau 《Human genetics》1996,97(3):359-361
Using a rat histidine decarboxylase (HDC) cDNA probe, we have mapped the HDC gene by in situ hybridization to the ql5–q2l region of human chromosom e15 and to the E5-G region of murine chromosome 2. These localizations strengthen a syntenic group conserved between human chromosome 15 and mouse chromosome 2. The localization of the HDC gene on the human chromosome 15 map shows that it is not included within the Prader-Willi Syndrome region (PWCR). 相似文献
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M. Montagna Olga Serova B. S. Sylla Marie-Geneviève Mattei Gilbert M. Lenoir 《Human genetics》1996,98(6):738-740
The h-PRL-1 gene codes for a new phosphotyrosine phosphatase that may play an important role in the control of basic cellular
processes such as cell growth and proliferation. Using the cDNA of the h-PRL-1 gene as a probe, we examined a somatic mouse
and hamster × human hybrid panel and found that chromosomes 1, 17 and 11 harbor sequences homologous to h-PRL-1. By in situ hybridization of metaphase spreads, subchromosomal localizations were determined at bands 1p35–p34, 17q12– q21 and 11q24–q25;
in addition, a faint signal was detected at 12q24. The chromosomal assignment of the genes homologous to h-PRL-1 will help
the investigation of its possible involvement in human diseases involving genetic alteration at these chromosomal regions.
Received: 12 June 1996 / Revised: 27 July 1996 相似文献
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Marie-Geneviève Mattei Andrée Krust Udo Stropp Jean-François Mattei Pierre Chambon 《Human genetics》1988,78(1):96-97
Summary The human progesterone receptor gene was localized by in situ hybridization to the q22 band of chromosome 11. 相似文献