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41.
Martinelli L. A. Nardoto G. B. Soltangheisi A. Reis C. R. G. Abdalla-Filho A. L. Camargo P. B. Domingues T. F. Faria D. Figueira A. M. Gomes T. F. Lins S. R. M. Mardegan S. F. Mariano E. Miatto R. C. Moraes R. Moreira M. Z. Oliveira R. S. Ometto J. P. H. B. Santos F. L. S. Sena-Souza J. Silva D. M. L. Silva J. C. S. S. Vieira S. A. 《Biogeochemistry》2021,154(2):425-426
Biogeochemistry - The initial online publication contained typesetting mistakes in the author information. The original article has been corrected. 相似文献
42.
Jonathan C. Guito Joseph B. Prescott Catherine E. Arnold Brian R. Amman Amy J. Schuh Jessica R. Spengler Tara K. Sealy Jessica R. Harmon JoAnn D. Coleman-McCray Kirsten A. Kulcsar Elyse R. Nagle Raina Kumar Gustavo F. Palacios Mariano Sanchez-Lockhart Jonathan S. Towner 《Current biology : CB》2021,31(2):257-270.e5
43.
Jardón-Valadez Eduardo Chen Charles H. García-Garibay Mariano Jiménez-Guzmán Judith Ulmschneider Martin B. 《Food biophysics》2021,16(1):70-83
Food Biophysics - Absorption of bioactive peptides in the intestinal epithelium take place in the apical or the basolateral tight junctions of the cells. Depending on the peptide size and... 相似文献
44.
Jenni Menon Mariano 《应用发育科学》2013,17(3):139-147
Applying latent class and regression techniques to data from the NICHD Study of Early Child Care and Youth Development (n = 997), this study explored the potential academic advantages of time spent in out-of-school activities. Of particular interest was how these potential advantages played out in relation to the timing and duration of activity participation and the family contexts in which it occurred. Participation closer to the start of high school—including consistent participants and latecomers—was associated with higher grades at the transition into high school, especially for youth from low-income families. Sensitivity analyses indicated that this link between school-age activity participation and adolescent academic progress was unlikely to be solely a function of selection. It also tended to be more pronounced among youth from lower-income families, although without varying by other aspects of family status or process. 相似文献
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47.
Volumetric properties underlying ligand binding in a monomeric hemoglobin: A high-pressure NMR study
Mariano Dellarole Christian Roumestand Catherine Royer Juliette T.J. Lecomte 《Biochimica et Biophysica Acta - Proteins and Proteomics》2013,1834(9):1910-1922
The 2/2 hemoglobin of the cyanobacterium Synechococcus sp. PCC 7002, GlbN, coordinates the heme iron with two histidines and exists either with a b heme or with a covalently attached heme. The binding of exogenous ligands displaces the distal histidine and induces a conformational rearrangement involving the reorganization of internal void volumes. The formation of passageways within the resulting conformation is thought to facilitate ligand exchange and play a functional role. Here we monitored the perturbation induced by pressure on the ferric bis-histidine and cyanide-bound states of GlbN using 1H–15N HSQC NMR spectroscopy. We inspected the outcome with a statistical analysis of 170 homologous 2/2 hemoglobin sequences. We found that the compression landscape of GlbN, as represented by the variation of an average chemical shift parameter, was highly sensitive to ligand swapping and heme covalent attachment. Stabilization of rare conformers was observed at high pressures and consistent with cavity redistribution upon ligand binding. In all states, the EF loop was found to be exceptionally labile to pressure, suggesting a functional role as a semi-flexible hinge between the adjacent helices. Finally, coevolved clusters presented a common pattern of compensating pressure responses. The high-pressure dissection combined with protein sequence analysis established locations with volumetric signatures relevant to residual communication of 2/2 hemoglobins. This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. 相似文献
48.
M. Rosario Darquier Cecilia F. Bessega Mariano Cony Juan C. Vilardi Beatriz O. Saidman 《Tree Genetics & Genomes》2013,9(1):307-320
Prosopis flexuosa is an arboreal Leguminosae that grows in arid and semiarid temperate zones of Argentina, in the Monte eco-region. It is a promising native forest species for recovering arid and semiarid regions because it plays an important role in erosion control as well as in soil fertility. Furthermore, it provides diverse economical resources. The main challenge to the forestry sector is finding a balance between production and forest protection. For this purpose, it is necessary to gather information about genetic parameters. In this study, we measured the distribution of the variation of 14 quantitative traits in an experimental half-sib stand, where families are representative of hierarchically structured populations. We applied a multivariate extension of the classical Q ST –F ST neutrality test to determine the relative importance of drift versus selection in the distribution of genetic variability. We found strong evidence that different selective regimes act on different traits and that selection favors different optima in each sampling site. The selection to different optima is much stronger among than within provenances. This result helps explain the possible causes for the regional variation observed in P. flexuosa and to define the management units and the evolutionarily significant units for this species. 相似文献
49.
Carla Rossini Crepaldi Phelipe Augusto Mariano Vitale Andrea Cristina Tesch Hélen Julie Laure José César Rosa Marcelo de Cerqueira César 《Mitochondrion》2013,13(6):823-830
Two types of binding sites for hexokinase, designated as Type A or Type B sites, have been shown to coexist on brain mitochondria. The ratio of these sites varies between species.HK1 attaches by reversibly binding to the voltage dependent anion channel (VDAC). Regarding the nature of hexokinase binding sites, we investigated if it was linked to distinct VDAC interactomes. We approached this question by 2D BN/SDS-PAGE of mitochondria, followed by mass spectrometry.Our results are consistent with the possibility that the ratio of Type A/Type B sites is due to differential VDAC interactions in bovine and rat neuronal cells. 相似文献
50.
Elena González-Sánchez Juan Martín-Caballero Juana María Flores Javier Hernández-Losa Ma ángeles Montero Javier Cortés Roso Mares Mariano Barbacid Juan A. Recio 《PloS one》2013,8(6)
Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression. Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAFV600E) are found in 3% of human non-small cell lung cancers. Contrary to KRAS mutant tumors, BRAFV600E-induced tumors are benign adenomas that fail to progess. Interestingly, loss of tumor supressor LKB1 coexists with KRAS oncogenic mutations and synergizes in tumor formation and progression, however, its cooperation with BRAFV600E oncogene is unknown. Our results describe a lung cell population in neonates mice where expression of BRAFV600E leads to lung adenoma development. Importantly, expression of BRAFV600E concomitant with the loss of only a single-copy of Lkb1, overcomes senencence–like features of BRAFV600E-mutant adenomas leading malignization to carcinomas. These results posit LKB1 haploinsufficiency as a risk factor for tumor progression of BRAFV600E mutated lung adenomas in human cancer patients. 相似文献