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111.
Marianne Stahl 《Planta》1949,37(1):103-148
Ohne ZusammenfassungMit 27 Textabbildungen. 相似文献
112.
113.
114.
Marianne Piteau Panagiotis Papatheodorou Carsten Schwan Andreas Schlosser Klaus Aktories Gudula Schmidt 《PLoS pathogens》2014,10(1)
The Cytotoxic Necrotizing Factor 1 (CNF1) is a protein toxin which is a major virulence factor of pathogenic Escherichia coli strains. Here, we identified the Lutheran (Lu) adhesion glycoprotein/basal cell adhesion molecule (BCAM) as cellular receptor for CNF1 by co-precipitation of cell surface molecules with tagged toxin. The CNF1-Lu/BCAM interaction was verified by direct protein-protein interaction analysis and competition studies. These studies revealed amino acids 720 to 1014 of CNF1 as the binding site for Lu/BCAM. We suggest two cell interaction sites in CNF1: first the N-terminus, which binds to p37LRP as postulated before. Binding of CNF1 to p37LRP seems to be crucial for the toxin''s action. However, it is not sufficient for the binding of CNF1 to the cell surface. A region directly adjacent to the catalytic domain is a high affinity interaction site for Lu/BCAM. We found Lu/BCAM to be essential for the binding of CNF1 to cells. Cells deficient in Lu/BCAM but expressing p37LRP could not bind labeled CNF1. Therefore, we conclude that LRP and Lu/BCAM are both required for toxin action but with different functions. 相似文献
115.
Ohne ZusammenfassungMit 42 Textabbildungen. 相似文献
116.
Marianne Brinckmann 《Archives of microbiology》1960,37(2):161-187
Ohne ZusammenfassungDissertation der Naturwissenschaftlichen Fakultät der Universität Frankfurt am Main. 相似文献
117.
PAX3 Confers Functional Heterogeneity in Skeletal Muscle Stem Cell Responses to Environmental Stress
118.
Michael J. Renner Allyson J. Bennett Michele L. Ford Peter J. Pierre 《Primates; journal of primatology》1992,33(3):315-327
Investigatory behavior with novel, inanimate objects by two groups of four juvenile greater bushbabies (Otolemur garnettii) was examined in the laboratory. Substantial investigatory behavior was shown by all subjects. In the first study, subjects
showed interest in a wide variety of nonfood stimulus objects. In the second, subjects displayed sustained interest in and
investigation of non-food stimulus objects over three sessions. Bushbabies showed preferences for larger, more manipulable
objects and variations in total contact over days. Individual differences were observed in the duration and types of contact
with objects. These observations contradict earlier reports that prosimians show little interest in inanimate, non-food objects. 相似文献
119.
Lana Weber Atar Gilat Nathanael Maillot Deborah Byrne Pascal Arnoux Marie-Thérèse Giudici-Orticoni Vincent Méjean Marianne Ilbert Olivier Genest Rina Rosenzweig Sébastien Dementin 《Environmental microbiology》2023,25(11):2447-2464
Bacterial genomes are a huge reservoir of genes encoding J-domain protein co-chaperones that recruit the molecular chaperone DnaK to assist protein substrates involved in survival, adaptation, or fitness. The atc operon of the aquatic mesophilic bacterium Shewanella oneidensis encodes the proteins AtcJ, AtcA, AtcB, and AtcC, and all of them, except AtcA, are required for growth at low temperatures. AtcJ is a short J-domain protein that interacts with DnaK, but also with AtcC through its 21 amino acid C-terminal domain. This interaction network is critical for cold growth. Here, we show that AtcJ represents a subfamily of short J-domain proteins that (i) are found in several environmental, mostly aquatic, β- or ɣ-proteobacteria and (ii) contain a conserved PX7W motif in their C-terminal extension. Using a combination of NMR, biochemical and genetic approaches, we show that the hydrophobic nature of the tryptophan of the S. oneidensis AtcJ PX7W motif determines the strong AtcJ–AtcC interaction essential for cold growth. The AtcJ homologues are encoded by operons containing at least the S. oneidensis atcA, atcB, and atcC homologues. These findings suggest a conserved network of DnaK and Atc proteins necessary for low-temperature growth and, given the variation in the atc operons, possibly for other biological functions. 相似文献
120.