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Mariana Cerda-Esteve Agustín Ruiz-González Mindaugas Gudelis Albert Goday Javier Trujillano Elisa Cuadrado Juan Francisco Cano 《Endocrinología y nutrición》2010,57(5):182-186
IntroductionHyponatremia is considered the most frequent electrolyte disorder found in hospitalized patients and seems to be a prognostic factor during hospitalization.MethodsA prospective observational study was carried out in consecutive neurological patients admitted to our hospital over a 3-month period. Blood and urinary ionogram and osmolality were determined at entry and 3–5 days after admission in all patients with hyponatremia.ResultsOf the 130 patients admitted, 19 (14.6%) had hyponatremia. The causes of hyponatremia were as follows: inappropriate fluid replacement in 4 patients (21%), antihypertensive drugs in 4 (21%), syndrome of inappropriate secretion of antidiuretic hormone in 4 (21%), cerebral salt wasting syndrome in 2 (10%), and edematous status caused by liver disease in one and digestive loss in one (5%) each. Mortality was one (5%) and 0 (0%) among patients with and without hyponatremia, respectively.ConclusionHyponatremia is common in hospitalized neurological patients and can be misdiagnosed as a worsening of the main illness. 相似文献
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dos Santos Julia Matzenbacher de Oliveira Denise Silva Moreli Marcos Lazaro Benite-Ribeiro Sandra Aparecida 《Molecular and cellular biochemistry》2018,448(1-2):251-263
Molecular and Cellular Biochemistry - Dietary administration of orotic acid (OA), an intermediate in the pyrimidine biosynthetic pathway, is considered to provide a wide range of beneficial... 相似文献
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M. Arantxa Colchero Juan Carlos Salgado Mishel Unar-Munguía Mariana Molina Shuwen Ng Juan Angel Rivera-Dommarco 《PloS one》2015,10(12)
In 2014 an excise tax to non-alcoholic sweetened beverages (SSB) was implemented in Mexico. The objective of this paper is to study whether and to what degree these taxes passed-through onto SSB prices in urban areas overall and by region, type of beverage and package size. Prices were obtained from the National Institute of Statistics and Geography from 2011 to 2014. We applied a pre-post quasi-experimental approach using fixed effects models. In sensitivity analysis we applied other model specifications to test the robustness of the findings and we also present weighted estimations based on household purchases. The dependent variables are real prices of a specific beverage category; the main independent variables are dummies for each month of 2014, and the models adjust for time trends and seasonality. Results suggest that the SSB tax passed along to consumers for all SSBs and we found overshifting for the carbonated SSBs. A greater effect is seen among the small package sizes, and we see heterogeneous effects by region. Estimating the effect of the tax on prices is important to understand the potential effect on consumption. 相似文献
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Maria J. Pena Susana G. Guerreiro Júlio C. Rocha Tiago Morais Sofia S. Pereira Mariana P. Monteiro Nuno Borges 《Journal of cellular biochemistry》2019,120(8):13056-13065
Amino acid mixtures (AAM) are protein substitutes used for phenylketonuria treatment, but their metabolic effects have not been well characterized. The objective of this study was to compare the acute glycemic response to free amino acids (free AA) from AAM with the response to intact protein (iProtein). Male Wistar rats (n = 14) were administered by gavage a bolus of free AA (n = 7) or iProtein as albumin (n = 7) containing equivalent amounts of nitrogen. Blood glucose and insulin levels were measured at baseline and 15, 30, 60 and 120 minutes later, when gut GLP-1 content and pancreatic insulin, GLP-1 receptor and Ki67 expression were quantified at 120 minutes time point. After AAM, glucose area under the curve (free AA vs iProtein; P < 0.01), serum insulin levels at 120 minutes (free AA vs iProtein; P < 0.05), colon GLP-1 content (free AA vs iProtein; P < 0.01), pancreatic GLP-1 receptor (free AA vs iProtein; P < 0.01) and insulin expression (free AA vs iProtein; p < 0.01) were significantly lower as compared with iProtein. AAM increased Ki67 expression in pancreatic islets (free AA vs iProtein; P < 0.05). In conclusion, this study demonstrated that acute response to AAM differs from iProtein and is characterized by a lower glucose excursion, along with a decrease in gut GLP-1 and pancreatic GLP-1 receptor and insulin. This data suggests the modulation of glycemia by free AA is mediated by the incretin axis. 相似文献
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Juan M. Galeazzi Bedeho M. W. Mender Mariana Paredes James M. Tromans Benjamin D. Evans Loredana Minini Simon M. Stringer 《PloS one》2013,8(6)
We show how hand-centred visual representations could develop in the primate posterior parietal and premotor cortices during visually guided learning in a self-organizing neural network model. The model incorporates trace learning in the feed-forward synaptic connections between successive neuronal layers. Trace learning encourages neurons to learn to respond to input images that tend to occur close together in time. We assume that sequences of eye movements are performed around individual scenes containing a fixed hand-object configuration. Trace learning will then encourage individual cells to learn to respond to particular hand-object configurations across different retinal locations. The plausibility of this hypothesis is demonstrated in computer simulations. 相似文献
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