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461.
El-Ashmawy Nahla E. El-Zamarany Enas A. Khedr Eman G. Abo-Saif Mariam A. 《Molecular and cellular biochemistry》2019,457(1-2):83-91
Molecular and Cellular Biochemistry - Epithelial-mesenchymal transition (EMT) leads to tumor dissemination and metastasis. Metadherin (MTDH) is an oncogene that plays an important role in... 相似文献
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Abdulrahman Nabeel Ibrahim Meram Joseph Jensa Mariam Elkoubatry Hanan Mahmoud Al-Shamasi Al-Anood Rayan Menatallah Gadeau Alain Pierre Ahmed Rashid Eldassouki Hussein Hasan Anwarul Mraiche Fatima 《Molecular and cellular biochemistry》2022,477(6):1865-1872
Molecular and Cellular Biochemistry - Diabetes mellitus (DM)-induced cardiac morbidities have been the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2... 相似文献
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Reham Hammad Mona Abd EL Rahman Eldosoky Shaimaa Hani Fouad Abdelaleem Elgendy Amany M Tawfeik Mohamed Alboraie Mariam Fathy Abdelmaksoud 《Innate immunity》2021,27(3):240
Cell destruction results in plasma accumulation of cell-free DNA (cfDNA). Dynamic changes in circulating lymphocytes are features of COVID-19. We aimed to investigate if cfDNA level can serve in stratification of COVID-19 patients, and if cfDNA level is associated with alterations in lymphocyte subsets and neutrophil-to-lymphocyte ratio (NLR). This cross-sectional comparative study enrolled 64 SARS-CoV-2-positive patients. Patients were subdivided to severe and non-severe groups. Plasma cfDNA concentration was determined by real-time quantitative PCR. Lymphocyte subsets were assessed by flow cytometry. There was significant increase in cfDNA among severe cases when compared with non-severe cases. cfDNA showed positive correlation with NLR and inverse correlation with T cell percentage. cfDNA positively correlated with ferritin and C-reactive protein. The output data of performed ROC curves to differentiate severe from non-severe cases revealed that cfDNA at cut-off ≥17.31 ng/µl and AUC of 0.96 yielded (93%) sensitivity and (73%) specificity. In summary, excessive release of cfDNA can serve as sensitive COVID-19 severity predictor. There is an association between cfDNA up-regulation and NLR up-regulation and T cell percentage down-regulation. cfDNA level can be used in stratification and personalized monitoring strategies in COVID-19 patients. 相似文献
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Rana Ghaleb Mariam Naciri Rasoul Al-Majmaie Amel Maki Mohamed Al-Rubeai 《Cytotechnology》2014,66(5):761-767
This study tested the effectiveness of laser biostimulation in small-scale cultures in vitro. We investigated the response of recombinant CHO cells, which are used for the production of monoclonal antibody, to low level laser radiation. The cells were irradiated using a 632.8 nm He–Ne laser in a continuous wave mode at different energy doses. We incubated the irradiated cells in small batch cultures and assessed their proliferation and productivity at various time intervals. Compared to untreated cells, the irradiated cells showed a significant increase in antibody production. Moreover, the results showed that laser irradiation did not affect viability and slightly enhanced proliferation rate. 相似文献
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Antonio Gálvez Mercedes Maqueda Manuel Martínez-Bueno Mariam Lebbadi Eva Valdivia 《Applied microbiology and biotechnology》1993,39(4-5):438-442
An antifungal substance named peptide A12-C has been purified to homogeneity from supernatants of sporulated cultures of Bacillus licheniformis A12. It consists of a 0.77-kDa hydrophilic peptide containing two residues of Glu and one of Arg, Ala, Pro, Tyr and Orn. No fatty acids, phosphorus or carbohydrates have been detected. Peptide A12-C is active on several fungi (Microsporum canis CECT 2797, Mucor mucedo CECT 2653, M. plumbeus (CCM F 443, Sporothrix schenckii CECT 2799 and Trichophyton mentagrophytes CECT 2793) and bacteria (Bacillus megaterium, Corynebacterium glutamicum, Sarcina and Mycobacterium), although the latter are less sensitive.
Correspondence to: A. Gálvez 相似文献