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BOLA‐DRB3 gene polymorphisms influence bovine leukaemia virus infection levels in Holstein and Holstein × Jersey crossbreed dairy cattle 下载免费PDF全文
H. A. Carignano M. J. Beribe M. E. Caffaro A. Amadio J. P. Nani G. Gutierrez I. Alvarez K. Trono M. M. Miretti M. A. Poli 《Animal genetics》2017,48(4):420-430
Bovine leukemia virus (BLV) infections, causing persistent lymphocytosis and lethal lymphosarcoma in cattle, have reached high endemicity on dairy farms. We observed extensive inter‐individual variation in the level of infection (LI) by assessing differences in proviral load in peripheral blood. This phenotypic variation appears to be determined by host genetics variants, especially those located in the BoLA‐DRB3 MHCII molecule. We performed an association study using sequencing‐based typed BOLA‐DRB3 alleles from over 800 Holstein and Holstein × Jersey cows considering LI in vivo and accounting for filial relationships. The DBR3*0902 allele was associated with a low level of infection (LLI) (<1% of circulating infected B‐cells), whereas the DRB3*1001 and DRB3*1201 alleles were related to a high level of infection (HLI). We found evidence that 13 polymorphic positions located in the pockets of the peptide‐binding cleft of the BOLA‐DRB3 alleles were associated with LI. DRB3*0902 had unique haplotypes for each of the pockets: Ser13‐Glu70‐Arg71‐Glu74 (pocket 4), Ser11‐Ser30 (pocket 6), Glu28‐Trp61‐Arg71 (pocket 7) and Asn37‐Asp57 (pocket 9), and all of them were significantly associated with LLI. Conversely, Lys13‐Arg70‐Ala71‐Ala74 and Ser13‐Arg70‐Ala71‐Ala74, corresponding to the DRB3*1001 and *1201 alleles respectively, were associated with HLI. We showed that the specific amino acid pattern in the DRB3*0902 peptide‐binding cleft may be related to the set point of a very low proviral load level in adult cows. Moreover, we identified two BOLA‐DRB3 alleles associated with a HLI, which is compatible with a highly contagious profile. 相似文献
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Nágila Zuchi Cristhiana Röpke Akemi Shibuya Thatyla Farago Marina Carmona Jansen Zuanon Sidineia Amadio 《Zeitschrift fur angewandte Ichthyologie》2020,36(6):837-841
Length-weight relationship (LWR) for 39 freshwater fish species captured in the Catalão Lake, a floodplain area at the confluence of the Amazonas and Negro rivers is presented. LWRs were calculated based on fish sampled over 18 years (1999–2017) using a set of ten gill nets with different mesh sizes, monthly immersed in water for 24-hr with 6-hr interval catches. Measurements were done for standard length (SL – 0.1 cm precision) and total weight (TW – 0.01 g precision). The LWRs were calculated by the linear regression of natural log-transformed SL and TW data: TW = a × SLb. All statistical analyses were performed with R software. From all species considered, 32 are new LWR records for the international literature as well as for the Amazonian ichythyofauna; additional records expand the known size range for seven species. 相似文献
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Susanna Amadio Fabrizio Vacca Alessandro Martorana Giuseppe Sancesario Cinzia Volonté 《BMC developmental biology》2007,7(1):77
Background
In the CNS, several P2 receptors for extracellular nucleotides are identified on neurons and glial cells to participate to neuron-neuron, glia-glia and glia-neuron communication. 相似文献89.
T W Bojadsen E S Silva A J Rodrigues A C Amadio 《Journal of electromyography and kinesiology》2000,10(3):143-149
Imbalance of Mm. Multifidi may play a role in spinal disorders such as scoliosis in the thoracic spine, and lumbar disc herniation and lower back pain in the lumbar spine. Even though changes in these muscles are related to the etiology of these disorders, their anatomy is still poorly understood, especially in the upper regions of the spine. With the aim of gaining a better understanding of the anatomy of Mm. Multifidi in the lumbar and thoracic spine, 12 fresh and two embalmed cadavers were dissected. Our results indicate that Mm. Multifidi present differences in lumbar and thoracic spines concerning their deepness, fibre trajectory, muscle length, muscle mass and tendinous tissue. In the lumbar spine Mm. Multifidi are a superficial, thick and fleshy mass, and their fibres are more vertical in relation to the spinous processes. In the thoracic spine Mm. Multifidi are deeper, thinner, and their fibres are more tendinous and oblique than in the lumbar spine. These differences have implications on Mm. Multifidi architecture and consequently for their function in these two regions of the spine. 相似文献