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991.
Felipe F.D. Oliveira Diego C.B.D. Santos Alexandre A.M. Lapis José R. Corrêa Alexandre F. Gomes Fabio C. Gozzo Paulo F. Moreira Virgínia C. de Oliveira Frank H. Quina Brenno A.D. Neto 《Bioorganic & medicinal chemistry letters》2010,20(20):6001-6007
Newly designed 2,1,3-benzothiadiazole-containing fluorescent probes with four excited state intramolecular proton transfer (ESIPT) sites were successfully tested in live cell-imaging assays using a confluent monolayer of human stem-cells (tissue). All tested dyes were compared with the commercially available DAPI and gave far better results. 相似文献
992.
Massimo Ghizzoni André Boltjes Chris de Graaf Hidde J. Haisma Frank J. Dekker 《Bioorganic & medicinal chemistry》2010,18(16):5826-5834
Several lines of evidence indicate that histone acetyltransferases (HATs) are novel drug targets for treatment of diseases like, for example, cancer and inflammation. The natural product anacardic acid is a starting point for development of small molecule inhibitors of the histone acetyltransferase (HAT) p300/CBP associated factor (PCAF). In order to optimize the inhibitory potency, a binding model for PCAF inhibition by anacardic acid was proposed and new anacardic acid derivatives were designed. Ten new derivatives were synthesized using a novel synthetic route. One compound showed a twofold improved inhibitory potency for the PCAF HAT activity and a twofold improved inhibition of histone acetylation in HEP G2 cells. 相似文献
993.
Débora Barbosa Vendramini-Costa Ilton Barros Daltro de Castro Ana Lúcia Tasca Góis Ruiz Cilene Marquissolo Ronaldo Aloise Pilli João Ernesto de Carvalho 《Bioorganic & medicinal chemistry》2010,18(18):6742-6747
In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself. 相似文献
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996.
Valdirene Neves Monteiro Roberto do Nascimento Silva Andrei Stecca Steindorff Fabio Teles Costa Eliane Ferreira Noronha Carlos André Ornelas Ricart Marcelo Valle de Sousa Marilene Henning Vainstein Cirano José Ulhoa 《Current microbiology》2010,61(4):298-305
Trichoderma harzianum ALL42 were capable of overgrowing and degrading Rhizoctonia solani and Macrophomina phaseolina mycelia, coiling around the hyphae with formation of apressoria and hook-like structures. Hyphae of T. harzianum ALL42 did not show any coiling around Fusarium sp. hyphae suggesting that mycoparasitism may be different among the plant pathogens. In this study, a secretome analysis
was used to identify some extracellular proteins secreted by T. harzianum ALL42 after growth on cell wall of M. phaseolina, Fusarium sp., and R. solani. The secreted proteins were analyzed by two-dimensional electrophoresis and MALDI-TOF mass spectrometry. A total of 60 T. harzianum ALL42 secreted proteins excised from the gel were analyzed from the three growth conditions. While seven cell wall-induced
proteins were identified, more than 53 proteins spots remain unidentified, indicating that these proteins are either novel
proteins or proteins that have not yet been sequenced. Endochitinase, β-glucosidase, α-mannosidase, acid phosphatase, α-1,3-glucanase,
and proteases were identified in the gel and also detected in the supernatant of culture. 相似文献
997.
Jinze Noordijk C. J. M. Musters Jerry van Dijk Geert R. de Snoo 《Biodiversity and Conservation》2010,19(11):3255-3268
Sown, temporary field margins are a common agri-environment scheme (AES) in the Netherlands. Despite their wide application, though, there has been scarcely any long-term monitoring of the succession of invertebrates. In the field margins of 40 farms, invertebrate diversity and the abundance of three functional groups were assessed in relation to age. The diversity in terms of number of species groups was found to increase with the age of the margins. The abundance of herbivores and detritivores also showed a positive correlation with the age of the margins. However, the abundance of predators decreased with increasing age. Older margins showed a higher total vegetation cover and fewer plant species, also resulting in lower plant species evenness. We suggest several changes to the current AES regulations. For the conservation of invertebrate diversity, longer-lasting field margins are desirable. In addition, old margins are favoured by detritivores, a group that has particular difficulty finding suitable habitats in agricultural landscapes. However, such margins are less favourable from an agricultural perspective, as they appear unsuitable for high abundances of potentially useful predators and the high vegetation cover attracts many potentially harmful herbivores. To circumvent this, the AES might be extended by incorporating hay-making, which would reduce standing biomass and might lead to more predators and fewer herbivores. 相似文献
998.
Maria Giovanna Riparbelli 《Tissue & cell》2010,42(2):69-80
Centrioles are involved in the formation of cilia and flagella and in the organization of the centrosome, the main microtubule-organizing center of the cell. Since structural and functional centriole aberrations can contribute to several human diseases, these organelles have recently focused the attention of cell biologists. Here, we review data on the insect centrioles, reporting non-canonical aspects of their behaviour, function and architecture. These findings that represent obvious exceptions to the established rule might contribute to advance our understanding in the formation and the function of centrioles. 相似文献
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