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181.
Dopaminergic activity is expected to be altered in patients with Huntington’s disease (HD) and be related to factors like
duration and severity of illness or patients’ specific symptomatology like dementia, depression, or psychotic features. We
assessed plasma homovanillic acid (pHVA) and plasma prolactin (pPRL), two correlates of dopaminergic activity, in 116 subjects
with CAG repeats expansion in the HD gene, 26 presymptomatic (18 females) and 90 with overt symptomatology (43 females). Patients
were evaluated using the Unified HD Rating Scale and the Total Functional Capacity Scale. Presence of dementia, depression,
and psychotic features were also assessed. The age range of the patients was 22–83 years, duration of illness from 0.5 to
27 years, and CAG repeat number from 34 to 66. A group of 60 age and sex matched healthy subjects served as control group.
Plasma PRL in subjects at risk and in neuroleptic-free patients, evaluated separately for males and females, did not differ
from controls. Plasma HVA levels did not differ from controls in the group of presymptomatic subjects, but were significantly
higher in the patients group. This increase was positively associated mainly with severity of illness and functional capacity
of the patients, and not with presence of depression or dementia. Plasma HVA levels may be proven to be a peripheral index
of disease progression. Reducing dopaminergic activity may have not only symptomatic, but also neuroprotective effects in
HD. 相似文献
182.
Manolis Pasparakis Lena Alexopoulou Eleni Douni George Kollias 《Cytokine & growth factor reviews》1996,7(3):223-229
Tumour necrosis factors have been classically studied as molecules central to the pathogenesis of infectious, inflammatory and autoimmune diseases. The recent generation of mice deficient in TNFα, LTα, or their receptors, has provided exciting new insights into the physiological role of these molecules in the development of secondary lymphoid tissues and in the organisation of the Immoral immune response. 相似文献
183.
Manolis Maragkakis Panagiotis Alexiou Tadashi Nakaya Zissimos Mourelatos 《RNA (New York, N.Y.)》2016,22(1):1-9
Immunoprecipitation of RNA binding proteins (RBPs) after in vivo crosslinking, coupled with sequencing of associated RNA footprints (HITS-CLIP, CLIP-seq), is a method of choice for the identification of RNA targets and binding sites for RBPs. Compared with RNA-seq, CLIP-seq analysis is widely diverse and depending on the RBPs that are analyzed, the approaches vary significantly, necessitating the development of flexible and efficient informatics tools. In this study, we present CLIPSeqTools, a novel, highly flexible computational suite that can perform analysis from raw sequencing data with minimal user input. It contains a wide array of tools to provide an in-depth view of CLIP-seq data sets. It supports extensive customization and promotes improvization, a critical virtue, since CLIP-seq analysis is rarely well defined a priori. To highlight CLIPSeqTools capabilities, we used the suite to analyze Ago-miRNA HITS-CLIP data sets that we prepared from human brains. 相似文献
184.
George C. Adamidis Panayiotis G. Dimitrakopoulos Apostolos Manolis Aristotelis C. Papageorgiou 《Plant Systematics and Evolution》2014,300(9):2051-2060
Alyssum lesbiacum is a well-established Ni hyperaccumulator, endemic to serpentine soils of Lesbos Island (Greece). A total of 95 individuals were collected from 17 plots encompassing the only four large populations of this species. ISSR (Inter-simple sequence repeat) markers were used to assess genetic diversity and population structure of A. lesbiacum to provide initial guidance for the development of successful management and conservation measures. A total of ten primers produced 82 bands, 96.34 % being polymorphic. The largest part of total diversity was found within populations, rather than among them. AMOVA analysis partitioned the largest part of diversity within plots (66 %), while 15 % contained among plots within populations and 19 % among populations. Principal coordinates analysis along with dendrogram based on genetic distances among populations showed a high degree of genetic differentiation of the isolated population Loutra. At a smaller scale, distance was not the most significant factor influencing the patterns of genetic diversity, but topography, ecosystem types and connectivity through streams. According to our results, conservation efforts should be organized at the level of watersheds and ecosystem types, considering them as management units. For ex situ conservation and restoration, seed samplings should be representative of the different habitats and watersheds as well as the patches of large and small populations while keeping the east population of Loutra separate from the other three central populations, to avoid any loss of genetic diversity and to preserve the character of the local adapted populations. 相似文献
185.
186.
Carla Reale Anna Iervolino Ivan Scudiero Angela Ferravante Luca Egildo D'Andrea Pellegrino Mazzone Tiziana Zotti Antonio Leonardi Luca Roberto Mariastella Zannini Tiziana de Cristofaro Muralitharan Shanmugakonar Giovambattista Capasso Manolis Pasparakis Pasquale Vito Romania Stilo 《The Journal of biological chemistry》2016,291(11):5765-5773
187.
George Nikitas Christos Maniotis George Manolis Athanasios G. Manolis 《Indian pacing and electrophysiology journal》2013,13(3):131-133
We present an image of pseudo-polymorphic ventricular tachycardia recording on a 12-lead surface ECG Holter. Although at first glance the appearance of the recording resembled polymorphic ventricular tachycardia, careful investigation revealed normal electrocardiographic findings. 相似文献
188.
Anthropometric dimensions of 1520 students of Biology at University of Athens in Greece were analysed to determine secular
changes of height and body proportions during a 20 year period. Since, 1970, means of standing height, subischial length,
and cormic index have been increased, although the rate of increase from 1986 to 1990 has been rather slow. On the contrary
the mean sitting height is stable, and cormic/ subischial index have been declined during the same period. There are no data
for comparing this sample with the general population, but we suppose that these changes in the body formation is common as
a result of the modern way of life. 相似文献
189.
Natural vs. mariculture induced variability in nutrients and plankton in the eastern Mediterranean 总被引:1,自引:0,他引:1
Paraskevi Pitta Ioannis Karakassis Manolis Tsapakis Snezana Zivanovic 《Hydrobiologia》1998,391(1-3):179-192
The water column in three Mediterranean fish farms was investigated in terms of physical, chemical and biological characteristics. A significant increase in concentrations of phosphate and ammonium was detected within the cages over the control site in one of the farms but without any significant effect on chlorophyll concentration. Analysis of variation within the data set identified location and season as the major factors of variability in most of the variables examined except phosphate and ammonium for which variability induced by fish farming seemed to be of major importance. Plankton abundance for the major taxonomic groups (diatoms, flagellates, dinoflagellates and ciliates), microplankton species diversity and community structure were also determined by the effects of season and location rather than by fish farming. 相似文献
190.
The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse 总被引:1,自引:0,他引:1