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Nearly one in five bird species has separate breeding and overwintering distributions, and the regular migrations of these species cause a substantial seasonal redistribution of avian diversity across the world. However, despite its ecological importance, bird migration has been largely ignored in studies of global avian biodiversity, with few studies having addressed it from a macroecological perspective. Here, we analyse a dataset on the global distribution of the world’s birds in order to examine global spatial patterns in the diversity of migratory species, including: the seasonal variation in overall species diversity due to migration; the contribution of migratory birds to local bird diversity; and the distribution of narrow-range and threatened migratory birds. Our analyses reveal a striking asymmetry between the Northern and Southern hemispheres, evident in all of the patterns investigated. The highest migratory bird diversity was found in the Northern Hemisphere, with high inter-continental turnover in species composition between breeding and non-breeding seasons, and extensive regions (at high latitudes) where migratory birds constitute the majority of the local avifauna. Threatened migratory birds are concentrated mainly in Central and Southern Asia, whereas narrow-range migratory species are mainly found in Central America, the Himalayas and Patagonia. Overall, global patterns in the diversity of migratory birds indicate that bird migration is mainly a Northern Hemisphere phenomenon. The asymmetry between the Northern and Southern hemispheres could not have easily been predicted from the combined results of regional scale studies, highlighting the importance of a global perspective. 相似文献
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Hajar Owji Navid Nezafat Manica Negahdaripour Ali Hajiebrahimi Younes Ghasemi 《European journal of cell biology》2018,97(6):422-441
Signal peptides (SP) are short peptides located in the N-terminal of proteins, carrying information for protein secretion. They are ubiquitous to all prokaryotes and eukaryotes. SPs have been of special interest in several scientific and industrial fields, including recombinant protein production, disease diagnosis, immunization, and laboratory techniques. Recently, the role of SPs in recombinant protein production has gained too much attention. Herein, several studies have been reviewed to elucidate the precise structure and function of SPs, particularly the optimized ones for recombinant protein production. However, some features of SPs still have remained obscure. In this review, some approaches concerning elucidation and optimization of SPs are discussed, and pragmatic conclusions and suggestions for future studies are also proposed. Moreover, a summary of secretory pathways, evolutionary changes, functions, applications, and different types of SPs is mentioned. At last, current limitations and prospects are discussed. 相似文献
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Florian?J. Clemente Alexia Cardona Charlotte?E. Inchley Benjamin?M. Peter Guy Jacobs Luca Pagani Daniel?J. Lawson Tiago Ant?o Mário Vicente Mario Mitt Michael DeGiorgio Zuzana Faltyskova Yali Xue Qasim Ayub Michal Szpak Reedik M?gi Anders Eriksson Andrea Manica Maanasa Raghavan Morten Rasmussen Simon Rasmussen Eske Willerslev Antonio Vidal-Puig Chris Tyler-Smith Richard Villems Rasmus Nielsen Mait Metspalu Boris Malyarchuk Miroslava Derenko Toomas Kivisild 《American journal of human genetics》2014,95(5):584-589
Arctic populations live in an environment characterized by extreme cold and the absence of plant foods for much of the year and are likely to have undergone genetic adaptations to these environmental conditions in the time they have been living there. Genome-wide selection scans based on genotype data from native Siberians have previously highlighted a 3 Mb chromosome 11 region containing 79 protein-coding genes as the strongest candidates for positive selection in Northeast Siberians. However, it was not possible to determine which of the genes might be driving the selection signal. Here, using whole-genome high-coverage sequence data, we identified the most likely causative variant as a nonsynonymous G>A transition (rs80356779; c.1436C>T [p.Pro479Leu] on the reverse strand) in CPT1A, a key regulator of mitochondrial long-chain fatty-acid oxidation. Remarkably, the derived allele is associated with hypoketotic hypoglycemia and high infant mortality yet occurs at high frequency in Canadian and Greenland Inuits and was also found at 68% frequency in our Northeast Siberian sample. We provide evidence of one of the strongest selective sweeps reported in humans; this sweep has driven this variant to high frequency in circum-Arctic populations within the last 6–23 ka despite associated deleterious consequences, possibly as a result of the selective advantage it originally provided to either a high-fat diet or a cold environment. 相似文献
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Lia Betti François Balloux Tsunehiko Hanihara Andrea Manica 《American journal of physical anthropology》2010,141(1):76-82
Human populations across the world vary greatly in cranial morphology. It is highly debated to what extent this variability has accumulated through neutral processes (genetic drift) or through natural selection driven by climate. By taking advantage of recent work showing that geographic distance along landmasses is an excellent proxy for neutral genetic differentiation, we quantify the relative role of drift versus selection in an exceptionally large dataset of human skulls. We show that neutral processes have been much more important than climate in shaping the human cranium. We further demonstrate that a large proportion of the signal for natural selection comes from populations from extremely cold regions. More generally, we show that, if drift is not explicitly accounted for, the effect of natural selection can be greatly overestimated. Am J Phys Anthropol, 2010. © 2009 Wiley‐Liss, Inc. 相似文献
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Prevalence of ColE1-Like Plasmids and Colicin K Production among Uropathogenic Escherichia coli Strains and Quantification of Inhibitory Activity of Colicin K 下载免费PDF全文
Matija Rijavec Maruka Budi
Peter Mrak Manica Müller-Premru Zdravko Podlesek Darja
gur-Bertok 《Applied microbiology》2007,73(3):1029-1032
Colicin K exhibited pronounced inhibitory activity against uropathogenic Escherichia coli (UPEC) strains. Low prevalence of colicin K production and a relatively high prevalence of ColE1-like plasmids were determined among 215 UPEC strains from Slovenia. Sequencing of the colicin K-encoding pColK-K235 revealed a mosaic structure and the presence of the insertion sequence IS2. 相似文献
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Marco Aurélio Echart Montano Juan Pablo Barrio Lera Maria Gabriela Valle Gottlieb Carla Helena Augustin Schwanke Maria Izabel Ugalde Marques da Rocha Maria Fernanda Manica-Cattani Greice Feyl dos Santos Ivana Beatrice Manica da Cruz 《Molecular and cellular biochemistry》2009,328(1-2):33-40
Evidence suggests an association between obesity and oxidative stress caused by superoxide production. Since the dismutation of superoxide is catalyzed by superoxide dismutase enzymes, we tested the association between obesity and Ala16Val manganese-dependent superoxide dismutase gene (MnSOD) polymorphism. We analyzed 815 free-living community subjects (≥60 years old) grouped into subjects who were either obese (BMI ≥ 30 kg/m2) or non-obese (BMI < 25 kg/m2). Additionally, we investigated the possible interaction between the Ala16Val MnSOD gene polymorphism and obesity in the modulation of biochemical and nutritional variables. We found a positive association between MnSOD polymorphism and obesity, since higher VV frequency (28.2%) was observed in the obese group (P = 0.002, odds ratio 1.949, 95% CI: 1.223–3.008). This result was independent of sex, age, diabetes, dyslipidemia, hypertension, and metabolic syndrome. A possible biological explanation of the association described here could be a chronic state of superoxide enzyme imbalance present in VV carriers, which could affect differential metabolic pathways contributing to the obese state. 相似文献
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Marcelle D. Alves Lia Pinheiro Denise Manica Laura M. Fogliatto Christina Fraga Luciano Z. Goldani 《Mycopathologia》2011,171(1):57-59
Histoplasma capsulatum has not typically been associated with sinusitis in either immunocompetent or immunocompromised hosts. We report a case of
sinusitis caused by H. capsulatum in a patient with chronic lymphocytic leukemia and discuss the reported cases of this rare clinical manifestation of histoplasmosis
in the medical literature. 相似文献