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21.
Monocrotaline (MCT) is a hepatotoxic pyrrolizidine alkaloid that is derived from plants; exposure may occur by consumption of contaminated grains, herbal teas and medicines. MCT can cause liver damage. We investigated the antioxidant effects of selenium (Se) and vitamin E against the toxic effects of MCT. Female Wistar albino rats were divided into four groups: a control group, an MCT group, an MCT + Se group, and an MCT + vitamin E group. Liver tissues were harvested, fixed, processed to paraffin and sections were cut. Anti-von Willebrand factor (vWF) immunohistochemistry, terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL), and hematoxylin and eosin staining were performed. Serum and liver tissue glutathione (GSH), catalase (CAT), and glutathione peroxidase (GPx) levels were measured. Histopathological and TUNEL data showed significantly increased liver damage in the MCT group compared to controls. Histopathological and TUNEL staining indicated significant improvements in the MCT + vitamin E and MCT + Se groups compared to the MCT group. MCT significantly reduced the serum GSH level and GPx activity, and liver GPx activity. Biochemical data indicated a significant improvement in serum GSH level in the MCT + vitamin E group compared to the MCT group. We suggest that vitamin E and Se afford limited protection against MCT hepatotoxicity. 相似文献
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Olga Pivovarova Christian von Loeffelholz Iryna Ilkavets Carsten Sticht Sergei Zhuk Veronica Murahovschi Sonja Lukowski Stephanie D?cke Jennifer Kriebel Tonia de las Heras Gala Anna Malashicheva Anna Kostareva Johan F Lock Martin Stockmann Harald Grallert Norbert Gretz Steven Dooley Andreas FH Pfeiffer Natalia Rudovich 《Cell cycle (Georgetown, Tex.)》2015,14(14):2293-2300
23.
Oxygen-pulse curves in rat liver mitochondrial suspensions. Some observations and deductions. 下载免费PDF全文
G P Archbold C L Farrington S A Lappin A M McKay F H Malpress 《The Biochemical journal》1979,180(1):161-174
1. The inference, implicit in the chemiosmotic hypothesis, that protons move into the bulk phase during ATP synthesis was investigated. 2. Incubation of rat liver mitochondria in the presence of the cation exchanger CM-Sephadex C-50 caused alkalinization in the medium, though total ATP synthesis remained unchanged. The addition of N-ethylmaleimide prevented the alkalinization, but there was still no indication of protons passing into the medium. The expected proton movement [Mitchell & Moyle (1967) Biochem. J. 105, 1147--1162] was readily detected when as an equivalent acid pulse. 3. Analysis of delta H+ decay curves after O2 pulses (3 micrograms-atoms of O/g of protein) indicated the presence of fast and slow components of decay, with first-order rate constants (k) of 0.24s-1 and 0.032s-1. The fast decay was finite and was eliminated in the presence of N-ethylmaleimide. 4. These observations are interpreted as evidence for the development of unmasking of fixed charges on the outer surface of the mitochondrial inner membrane during energization and for the existence of proton-retentive electrical fields (rho-zones) on this surface. The charge concentration is calculated as about 1 charge/10nm2. 5. A cycle of changes in a single fixed-charge molecule is proposed which mediates both Ca2+ uptake and the first step in the utilization of the rho-zone protonmotive force, delta p rho. 相似文献
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M Gowda Y Zhao T Würschum C FH Longin T Miedaner E Ebmeyer R Schachschneider E Kazman J Schacht J-P Martinant M F Mette J C Reif 《Heredity》2014,112(5):552-561
The accuracy of genomic selection depends on the relatedness between the members of the
set in which marker effects are estimated based on evaluation data and the types for which
performance is predicted. Here, we investigate the impact of relatedness on the
performance of marker-assisted selection for fungal disease resistance in hybrid wheat. A
large and diverse mapping population of 1739 elite European winter wheat inbred lines and
hybrids was evaluated for powdery mildew, leaf rust and stripe rust resistance in
multi-location field trials and fingerprinted with 9 k and 90 k SNP arrays.
Comparison of the accuracies of prediction achieved with data sets from the two marker
arrays revealed a crucial role for a sufficiently high marker density in genome-wide
association mapping. Cross-validation studies using test sets with varying degrees of
relationship to the corresponding estimation sets revealed that close relatedness leads to
a substantial increase in the proportion of total genotypic variance explained by the
identified QTL and consequently to an overoptimistic judgment of the precision of
marker-assisted selection. 相似文献
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Single-copy nuclear DNAs (scnDNAs) of eight species of arvicoline and six
species of murine rodents were compared using DNA-DNA hybridization. The
branching pattern derived from the DNA comparisons is congruent with the
fossil evidence and supported by comparative biochemical, chromosomal, and
morphological studies. The recently improved fossil record for these
lineages provides seven approximate divergence dates, which were used to
calibrate the DNA-hybridization data. The average rate of scnDNA divergence
was estimated as 2.5%/Myr. This is approximately 10 times the rate in the
hominoid primates. These results agree with previous reports of accelerated
DNA evolution in muroid rodents and extend the DNA-DNA hybridization data
set of Brownell.
相似文献
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