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941.
AI Fujita 《Physiological Entomology》2004,29(4):305-310
Abstract. Lysozymes are widely distributed in many organisms as one of the components of defence mechanisms. In herbivores, when nitrogen is not contained in sufficient amounts in the diet, bacteria lysed by stomach lysozymes are used as sources of nitrogen. In ruminants, lysozymes function as digestive enzymes in the true stomach. A convergence of amino acid sequence has been shown between the stomach lysozymes of different ruminants, and similar lysozymes have recently been reported in the gut or salivary gland of insects. In this mini review, the enzymatic and ecological functions of lysozymes in insects, particularly in termites, are introduced, together with future studies that are needed in this field. 相似文献
942.
Brandon H Cherry Anh Q Nguyen Roger A Hollrah Arthur G Williams Jr Besim Hoxha Albert H Olivencia-Yurvati Robert T Mallet 《Experimental biology and medicine (Maywood, N.J.)》2015,240(12):1774-1784
Cardiac electromechanical dysfunction may compromise recovery of patients who are initially resuscitated from cardiac arrest, and effective treatments remain elusive. Pyruvate, a natural intermediary metabolite, energy substrate, and antioxidant, has been found to protect the heart from ischemia-reperfusion injury. This study tested the hypothesis that pyruvate-enriched resuscitation restores hemodynamic, metabolic, and electrolyte homeostasis following cardiac arrest. Forty-two Yorkshire swine underwent pacing-induced ventricular fibrillation and, after 6 min pre-intervention arrest, 4 min precordial compressions followed by transthoracic countershocks. After defibrillation and recovery of spontaneous circulation, the pigs were monitored for another 4 h. Sodium pyruvate or NaCl were infused i.v. (0.1 mmol·kg−1·min−1) throughout precordial compressions and the first 60 min recovery. In 8 of the 24 NaCl-infused swine, the first countershock converted ventricular fibrillation to pulseless electrical activity unresponsive to subsequent countershocks, but only 1 of 18 pyruvate-treated swine developed pulseless electrical activity (relative risk 0.17; 95% confidence interval 0.13–0.22). Pyruvate treatment also lowered the dosage of vasoconstrictor phenylephrine required to maintain systemic arterial pressure at 15–60 min recovery, hastened clearance of excess glucose, elevated arterial bicarbonate, and raised arterial pH; these statistically significant effects persisted up to 3 h after sodium pyruvate infusion, while infusion-induced hypernatremia subsided. These results demonstrate that pyruvate-enriched resuscitation achieves electrocardiographic and hemodynamic stability in swine during the initial recovery from cardiac arrest. Such metabolically based treatment may offer an effective strategy to support cardiac electromechanical recovery immediately after cardiac arrest. 相似文献
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