Functional profiles typical of the male and female residents in different climatic-geographical areas of Magadan region

Residents of the Extreme North, in total 255 males and 72 females were examined to study morpho-fuctional changes occurring in dependence on the area of residence. It was found that the subjects who recide in the towns of Magadan and Susuman demonstrated adaptive changes in somatometric parameters as well as in functioning of the body cardio-respiratory and gas-transporting systems that can be considered as a compensatory response providing the body energy balance and homeostasis maintenance at the level the unfavourable environmental factors.     

Crosstalk between the FGFR2 and TP53 genes in breast cancer: data from an association study and epistatic interaction analysis

To evaluate the potential for gene-gene interaction effects in sporadic breast cancer (BC) risk, we studied combinations of the fibroblast growth factor receptor 2 (FGFR2) rs1219648 and tumor protein 53 (TP53) rs1042522, rs1625895, and rs17878362 polymorphisms in BC patients (n=388) and healthy persons (n=275). In addition to a single-locus effect manifested by the association of FGFR2 rs1219648 and TP53 rs1042522 polymorphisms with high BC risk, depending on menopause status (0.001相似文献   

Hybrid system based on quantum dots and photosystem 2 core complex

We show that semiconductor nanocrystals (quantum dots, QD) can be used to increase the absorption capacity of pigment-protein complexes. In a mixture of photosystem 2 core complex (PS2) and QD, the fluorescence of the latter decreases several-fold due to the transfer of the absorbed energy to the PS2 core complex. We discuss Forster’s inductive-resonance mechanism as a possible way of energy transfer in donor-acceptor pairs QD-PS2 core complex. Calculations based on the experimental data show that the enhancement of PS2 fluorescence and the rate of Q_A reduction increase up to 60% due to efficient energy migration from QD to PS2.     

Effects of salicylic and jasmonic acids on the components of pro/antioxidant system in potato plants infected with late blight

The effects of salicylic acid (SA) and jasmonic acid (JA) on plant defense responses were studied with aseptic potato (Solanum tuberosum L.) plantlets infected with Phytophthora infestans (Mont.) de Bary. Plant treatment with 10⁻⁶ M SA or 10⁻⁷ M JA induced plant resistance; the mixture of these acids was most efficient. After treatment with these compounds, phenolic compounds were accumulated and peroxidase was activated in the sites of pathogen localization, and this might be the reason of resistance enhancement. In addition, more H₂O₂ was accumulated in infected plants treated with JA or its mixture with SA but not in plants treated with SA alone. It might occur because of observed inhibition of catalase and activation of isoperoxidase with the isoelectric point (pI) of ∼9.3, which manifests an affinity for the pathogen cell wall. The data obtained allow us to recommend the application of these compounds for potato plant protection against late blight.     

Response of microbial communities of Lake Baikal to extreme temperatures

The survival rate, metabolic activity, and ability for growth of microbial communities of Lake Baikal have been first studied after exposure to extremely low temperatures (freeze-thawing) for different lengths of time. It has been shown that short-term freezing (1–3 days) inhibits the growth and activity of microbial communities. The quantity of microorganisms increased after 7-and 15-day freezing. In the periods of maximums, the total number of microorganisms in the test samples was twice as high as in the control. It was established that after more prolonged freezing the microorganisms required more time after thawing to adapt to new conditions. In the variants with 7-and 15-day freezing, the activities of defrosted microbial communities were three or more times higher than in the control. The survival rate and activity of Baikal microorganisms after freeze-thawing confirms the fact that the Baikal microbial communities are highly resistant to this type of stress impact.     

Requirements of Pseudomonas aeruginosaDissociants in Glucose, Nitrate, and Phosphate. Limiting Concentrations of the Nutrients during Batch Cultivation

Requirements of R-, S-, and M-dissociants of Pseudomonas aeruginosaK-2 strain in glucose, nitrate, and phosphate, as well as the error of determination, have been calculated from the data of 250 experiments on their batch cultivation on the media with the various initial content of these resources. The resource requirements of R- and S-dissociants appear indistinguishable within the error limits. The requirements of M-dissociant significantly differ from those of R- and S-forms; however, due to specific growth of the M-form, the confidence intervals of the measured values can overlap with those of R-space and S-forms. The obtained requirement values allow an evaluation of the studied resources concentration limiting the culture growth.     

Mechanisms of the inhibition of Fe2+-induced oxidation of phosphatidylcholine by polyhydroxynaphthoquinones

The kinetics of egg phosphatidylcholine oxidation induced by an artificial prooxidant Fe2+--ascorbate system or hematine was followed by oxygen uptake. The protective effect of natural free radical scavangers--polyhydroxynaphthoquinones, ionol (BHT), alpha-tocopherol and EDTA was estimated by the decrease of the phosphatidylcholine oxidation rate. EDTA was shown to inhibit the Fe2+--ascorbate-induced oxidation but had no effect on the hematine-induced oxidation. The inhibiting effect of polyhydroxynaphthoquinones on Fe2+--ascorbate-induced oxidation was 10-100 times as high as that on hematine-induced oxidation. The effects of BHT and alpha-tocopherol were the same in both models. Natural polyhydroxynaphthoquinones interacted with the free radical diphenylpicrylhydrazyl in stoichiometric ratios coinciding with the number of beta-hydroxyls in naphthoquinone molecules; the methylation of these hydroxyls fully suppressed such an interaction. Two possible mechanisms of action of polyhydroxynaphthoquinones as antioxidative agents are discussed. The first of these is coupled with the formation of Fe2+--PHNQ complexes, while the second one--with their effect as free radical scavengers. In both cases, beta-hydroxyls of naphthoquinone molecules were shown to play a key role.     

Parameters of cardiac hemodynamics and physical development in indigenous inhabitants and caucasoids of military age born in different Northeastern Regions of Russia

Comparative analysis of the basic parameters of physical development and cardiovascular system in indigenous inhabitants and north-born Caucasoids of different northeastern regions of Russia (the Chukotka Autonomous District, Magadan oblast) has been performed. No significant differences in most of morphological and functional parameters have been found between the groups of subjects, which proves that convergent adaptation processes occur under the current social conditions in both ethnic groups regardless of the region.