全文获取类型
收费全文 | 974篇 |
免费 | 82篇 |
国内免费 | 5篇 |
出版年
2024年 | 2篇 |
2023年 | 15篇 |
2022年 | 32篇 |
2021年 | 43篇 |
2020年 | 45篇 |
2019年 | 131篇 |
2018年 | 76篇 |
2017年 | 47篇 |
2016年 | 47篇 |
2015年 | 50篇 |
2014年 | 57篇 |
2013年 | 78篇 |
2012年 | 80篇 |
2011年 | 70篇 |
2010年 | 44篇 |
2009年 | 33篇 |
2008年 | 34篇 |
2007年 | 24篇 |
2006年 | 33篇 |
2005年 | 24篇 |
2004年 | 22篇 |
2003年 | 16篇 |
2002年 | 9篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1973年 | 2篇 |
1970年 | 2篇 |
1967年 | 1篇 |
排序方式: 共有1061条查询结果,搜索用时 31 毫秒
11.
Yaghoubi Atieh Khazaei Majid Ghazvini Kiarash Movaqar Aref Avan Amir Hasanian Seyed Mahdi Soleimanpour Saman 《International journal of peptide research and therapeutics》2021,27(2):1057-1067
International Journal of Peptide Research and Therapeutics - Whereas the traditional approaches of cancer therapy including radiotherapy, chemotherapy, and immunotherapy have failed to properly... 相似文献
12.
Majid Mohammadhosseini Claudio Frezza Alessandro Venditti Satyajit D. Sarker 《化学与生物多样性》2021,18(11):e2100317
The aim of this review article is to present, for the first time, an appraisal of the phytochemical, ethnobotanical and pharmacological data on Bunium species. The literature search was conducted using the Scopus, Google Scholar and PubMed databases. The genus Bunium has been found to produce both essential oil (EO), mainly comprising monoterpenes and sesquiterpenes, and non-volatile components mainly coumarins and flavonoids. There are several pharmacological activities associated with the Bunium species, especially antioxidant, antibacterial and antifungal properties. The chemotaxonomic appraisal of the phytochemical pattern of the genus is in sink with the current classification of the family. Moreover, this review confirms the significant ethnobotanical and pharmacological potential of different Bunium species. 相似文献
13.
Irum Sidra Andleeb Saadia Ali Amjad Rashid Muhammad Ibrahim Majid Mahnoor 《International journal of peptide research and therapeutics》2021,27(4):2313-2331
International Journal of Peptide Research and Therapeutics - Pseudomonas aeruginosa (P. aeruginosa) is a critical healthcare challenge due to its ability to cause persistent infections and the... 相似文献
14.
Sanaz Khaseb Mahdi Orooji Majid Ghasemian Pour Seyed Mohammadreza Safavi Mohammad Jafar Eghbal Maryam Rezai Rad 《Cell biology international》2021,45(9):1851-1865
Dental tissue-derived stem cells (DSCs) provide an easy, accessible, relatively noninvasive promising source of adult stem cells (ASCs), which brought encouraging prospective for their clinical applications. DSCs provide a perfect opportunity to apply for a patient's own ASC, which poses a low risk of immune rejection. However, problems associated with the long-term culture of stem cells, including loss of proliferation and differentiation capacities, senescence, genetic instability, and the possibility of microbial contamination, make cell banking necessary. With the rapid development of advanced cryopreservation technology, various international DSC banks have been established for both research and clinical applications around the world. However, few studies have been published that provide step-by-step guidance on DSCs isolation and banking methods. The purpose of this review is to present protocols and technical details for all steps of cryopreserved DSCs, from donor selection, isolation, cryopreservation, to characterization and quality control. Here, the emphasis is on presenting practical principles in accordance with the available valid guidelines. 相似文献
15.
Sahar Najafi Majid Ghanavat Saied Shahrabi Zahra Gatavizadeh Najmaldin Saki 《Cell biology international》2021,45(5):900-912
Inflammatory cytokines exert different effects on hematopoietic stem cells (HSCs), lead to the development of various cell lineages in bone marrow (BM) and are thus a differentiation axis for HSCs. The content used in this article has been obtained by searching PubMed database and Google Scholar search engine of English-language articles (1995–2020) using “Hematopoietic stem cell,” “Inflammatory cytokine,” “Homeostasis,” and “Myelopoiesis.” Inflammatory cytokines are involved in the differentiation and proliferation of hematopoietic progenitors to compensate for cellular death due to inflammation. Since each of these cytokines differentiates HSCs into a specific cell line, the difference in the effect of these cytokines on the fate of HSC progenitors can be predicted. Inhibitors of these cytokines can also control the inflammatory process as well as the cells involved in leukemic conditions. In general, inflammatory signaling can specify the dominant cell line in BM to counteract inflammation and leukemic condition via stimulating or inhibiting hematopoietic progenitors. Therefore, detection of the effects of inflammatory cytokines on the differentiation of HSCs can be an appropriate approach to check inflammatory and leukemic conditions and the suppression of these cytokines by their inhibitors allows for control of homeostasis in stressful conditions. 相似文献
16.
Sabah Moradi Mohammad Charkhpour Hamed Ghavimi Rasoul Motahari Majid Ghaderi Kambiz Hassanzadeh 《Journal of biomedical science》2013,20(1):77
Background
The exact mechanisms of morphine-induced dependence and withdrawal symptoms remain unclear. In order to identify an agent that can prevent withdrawal syndrome, many studies have been performed. This study was aimed to evaluate the effect of gap junction blockers; carbenoxolone (CBX) or mefloquine (MFQ); on morphine withdrawal symptoms in male rat.Adult male Wistar rats (225 – 275 g) were selected randomly and divided into 10 groups. All groups underwent stereotaxic surgery and in order to induce dependency, morphine was administered subcutaneously) Sc) at an interval of 12 hours for nine continuous days. On the ninth day of the experiment, animals received vehicle or CBX (100, 400, 600 μg/10 μl/rat, icv) or MFQ (50, 100 and 200 μg/10 μl/rat, icv) after the last saline or morphine (Sc) injection. Morphine withdrawal symptoms were precipitated by naloxone hydrochloride 10 min after the treatments. The withdrawal signs including: jumping, rearing, genital grooming, abdomen writhing, wet dog shake and stool weight, were recorded for 60 minutes.Results
Results showed that CBX and MFQ decreased all withdrawal signs; and the analysis indicated that they could attenuate the total withdrawal scores significantly.Conclusion
Taking together it is concluded that gap junction blockers prevented naloxone-precipitated withdrawal symptoms. 相似文献17.
Y. Kondo K. Sho M. A. Majid F. Okajima 《Nucleosides, nucleotides & nucleic acids》2013,32(5):1217-1218
Abstract In thyroid cells, a PI-agonist, via G1 like protein, enhanced a TSH-induced I?-efflux by intensifying a TSH-dependent inositol polyphosphate production followed by a Ca2+ mobilization, but diminished a TSH-dependent DNA synthesis by attenuating a TSH-dependent cAMP accumulation. 相似文献
18.
Karnyothrips cyathomorphus
sp. n. (Phlaeothripidae: Phlaeothripinae) is described as a new apterous species in the genus Karnyothrips Watson 1923, and it represents the fourth species of the genus to be recorded from China. A key to the Chinese species is given. 相似文献
19.
Kashif Bilal Samee U. Khan Sajjad A. Madani Khizar Hayat Majid I. Khan Nasro Min-Allah Joanna Kolodziej Lizhe Wang Sherali Zeadally Dan Chen 《Cluster computing》2013,16(3):575-589
The Information and Communication Technology sector is considered to be a major consumer of energy and has become an active participant in Green House Gas emissions. Lots of efforts have been devoted to make network infrastructure and network protocols power-aware and green. Among these efforts, Adaptive Link Rate (ALR) is one of the most widely discussed approaches. This survey highlights the most recent ALR approaches with a brief taxonomy and the state of the art. 相似文献
20.
Zena A. Al-Mudaris Aman S. A. Majid Dan Ji Ban A. Al-Mudarris Shih-Hsun Chen Po-Huang Liang Hasnah Osman Shah Kamal Khan Jamal Din Amin M. S. Abdul Majid 《PloS one》2013,8(11)
Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery. The benzyl vanillin (2-(benzyloxy)-3-methoxybenzaldehyde) compound shows anti-proliferative activity in HL60 leukemia cancer cells and can effect cell cycle progression at G2/M phase. Its apoptosis activity was due to disruption of mitochondrial functioning. In this study, we have studied a series of compounds consisting of benzyl vanillin and benzimidazole structures. We hypothesize that by fusing these two structures we can produce compounds that have better anticancer activity with improved specificity particularly towards the leukemia cell line. Here we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2XP, and (R) and (S)-1-(2-benzyloxy-3-methoxyphenyl)-2, 2, 2-trichloroethyl benzenesulfonate, 3BS and compared their activity to 2-benzyloxy-3-methoxybenzaldehyde, (Bn1), the parent compound. 2XP and 3BS induces cell death of U937 leukemic cell line through DNA fragmentation that lead to the intrinsic caspase 9 activation. DNA binding study primarily by the equilibrium binding titration assay followed by the Viscosity study reveal the DNA binding through groove region with intrinsic binding constant 7.39 µM/bp and 6.86 µM/bp for 3BS and 2XP respectively. 2XP and 3BS showed strong DNA binding activity by the UV titration method with the computational drug modeling showed that both 2XP and 3BS failed to form any electrostatic linkages except via hydrophobic interaction through the minor groove region of the nucleic acid. The benzylvanillin alone (Bn1) has weak anticancer activity even after it was combined with the benzimidazole (2MP), but after addition of another benzylvanillin structure (2XP), stronger activity was observed. Also, the combination of benzylvanillin with benzenesulfonate (3BS) significantly improved the anticancer activity of Bn1. The present study provides a new insight of benzyl vanillin derivatives as potential anti-leukemic agent. 相似文献