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151.
Andrew W. Thomas Emma J. Sherratt James W. Gagg Sarah A. Davies Majid. Aneela John C. Alcolado 《Human genetics》1997,101(2):212-213
A polymorphic microsatellite marker (D2S125) was recently reported to show significant linkage to non-insulin dependent diabetes
mellitus (NIDDM) in a population of Mexican-American affected sib-pairs. We have used a simple non-isotopic screening technique
employing the polymerase chain reaction (PCR) with a biotinylated primer to study the genetic linkage and allele frequency
distribution of the D2S125 marker in a population of 109 British NIDDMs (62 possible affected sib-pairs). The analysis provided
no evidence for linkage of the D2S125 marker in the British subjects (MLS = 0.029, P > 0.05). The PCR screening method used proved to be a convenient and reliable alternative to the radiolabelling of PCR products.
Received: 6 March 1997 / Accepted: 25 June 1997 相似文献
152.
The diagnostic and prognostic value of circulating microRNAs in coronary artery disease: A novel approach to disease diagnosis of stable CAD and acute coronary syndrome 下载免费PDF全文
153.
154.
Arash Aghajani Nargesi Majid Shalchi Reihaneh Aghajani Nargesi Niloofar Sadeghpour Mitra Zarifkar Majid Mozaffari Mehrnaz Imani Alireza Esteghamati Manouchehr Nakhjavani 《Cell stress & chaperones》2016,21(2):361-365
We aimed to study the relation between plasma levels of stress-induced heat shock protein 70 (HSPA1A) with plasminogen activator inhibitor-1 (PAI-1) and high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and HDL-C/Apo-A1 ratio. In a matched case-control study on patients with diabetes (40 patients with albuminuria and 40 without albuminuria matched for age, sex, and body mass index), we observed that plasma levels of HSPA1A and PAI-1 are increased in patients with albuminuria (0.55 ± 0.02 vs. 0.77 ± 0.04 ng/ml, p value <0.001 for HSPA1A; 25.9 ± 2 vs. 31.8 ± 2.4 ng/ml, p value <0.05 for PAI-1). There was a significant correlation between HSPA1A and PAI-1 in diabetic patients without albuminuria (r = 0.28; p value = 0.04), but not in those with albuminuria (r = 0.07; p value = 0.63). No association was found between HSPA1A and HDL-C, between HSPA1A and Apo-A1, or between HSPA1A and HDL-C/Apo-A1 ratio. We concluded that there is a direct correlation between plasma HSPA1A and PAI-1 levels in patients with diabetes, which is lost when they develop albuminuria. 相似文献
155.
Anas M. Alazami Sarah M. Al-Qattan Eissa Faqeih Amal Alhashem Muneera Alshammari Fatema Alzahrani Mohammed S. Al-Dosari Nisha Patel Afaf Alsagheir Bassam Binabbas Hamad Alzaidan Abdulmonem Alsiddiky Nasser Alharbi Majid Alfadhel Amal Kentab Riza M. Daza Martin Kircher Jay Shendure Mais Hashem Saif Alshahrani Zuhair Rahbeeni Ola Khalifa Ranad Shaheen Fowzan S. Alkuraya 《Human genetics》2016,135(5):525-540
156.
Claude Barberis Neil Moorcroft Chris Arendt Mikhail Levit Sandra Moreno-Mazza Joseph Batchelor Ingrid Mechin Tahir Majid 《Bioorganic & medicinal chemistry letters》2017,27(20):4730-4734
Novel N-substituted azaindoles have been discovered as PIM1 inhibitors. X-ray structures have played a significant role in orienting the chemistry effort in the initial phase of hit confirmation. Disclosure of an unconventional binding mode for 1 and 2, as demonstrated by X-ray crystallography, is presented and was an important factor in selecting and advancing a lead series. 相似文献
157.
Effects of extremely low frequency magnetic field on the development of tolerance to the analgesic effect of morphine in rats 下载免费PDF全文
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