Cross sectional study of primary care groups in London: association of measures of socioeconomic and health status with hospital admission rates

ObjectivesTo calculate socioeconomic and health status measures for the primary care groups in London and to examine the association between these measures and hospital admission rates.DesignCross sectional study.Setting66 primary care groups in London, total list size 8.0 million people.ResultsStandardised hospital admission ratios varied from 74 to 116 for total admissions and from 50 to 124 for emergency admissions. Directly standardised admission rates for asthma varied from 152 to 801 per 100 000 (mean 364) and for diabetes from 235 to 1034 per 100 000 (mean 538). There were large differences in the mortality, socioeconomic, and general practice characteristics of the primary care groups. Hospital admission rates were significantly correlated with many of the measures of chronic illness and deprivation. The strongest correlations were with disability living allowance (R=0.64 for total admissions and R=0.62 for emergency admissions, P<0.0001). Practice characteristics were less strongly associated with hospital admission rates.ConclusionsIt is feasible to produce a range of socioeconomic, health status, and practice measures for primary care groups for use in needs assessment and in planning and monitoring health services. These measures show that primary care groups have highly variable patient and practice characteristics and that hospital admission rates are associated with chronic illness and deprivation. These variations will need to be taken into account when assessing performance.     

Heat stress in grapevine: the pros and cons of acclimation

Heat stress is a major limiting factor of grapevine production and quality. Acclimation and recovery are essential to ensure plant survival, and the recovery mechanisms can be independent of the heat response mechanisms. An experimental set up with and without acclimation to heat followed by recovery [stepwise acclimation and recovery (SAR) and stepwise recovery (SR), respectively] was applied to two grapevine varieties, Touriga Nacional (TN), and Trincadeira (TR), with different tolerance to abiotic stress. Major differences were found between leaves of SAR and SR, especially after recovery; in SAR, almost all parameters returned to basal levels while in SR they remained altered. Acclimation led to a swifter and short‐term antioxidative response, affecting the plant to a lesser extent than SR. Significant differences were found among varieties: upon stress, TN significantly increased ascorbate and glutathione reduction levels, boosting the cell's redox‐buffering capacity, while TR needed to synthesize both metabolites, its response being insufficient to keep the redox state at working levels. TR was affected by stress for a longer period and the up‐regulation pattern of antioxidative stress genes was more obvious. In TN, heat shock proteins were significantly induced, but the canonical heat‐stress gene signature was not evident probably because no shutdown of the housekeeping metabolism was needed.     

Functional Connectivity Alterations in Epilepsy from Resting-State Functional MRI

The study of functional brain connectivity alterations induced by neurological disorders and their analysis from resting state functional Magnetic Resonance Imaging (rfMRI) is generally considered to be a challenging task. The main challenge lies in determining and interpreting the large-scale connectivity of brain regions when studying neurological disorders such as epilepsy. We tackle this challenging task by studying the cortical region connectivity using a novel approach for clustering the rfMRI time series signals and by identifying discriminant functional connections using a novel difference statistic measure. The proposed approach is then used in conjunction with the difference statistic to conduct automatic classification experiments for epileptic and healthy subjects using the rfMRI data. Our results show that the proposed difference statistic measure has the potential to extract promising discriminant neuroimaging markers. The extracted neuroimaging markers yield 93.08% classification accuracy on unseen data as compared to 80.20% accuracy on the same dataset by a recent state-of-the-art algorithm. The results demonstrate that for epilepsy the proposed approach confirms known functional connectivity alterations between cortical regions, reveals some new connectivity alterations, suggests potential neuroimaging markers, and predicts epilepsy with high accuracy from rfMRI scans.     

Craniofacial Reconstruction Using Rational Cubic Ball Curves

This paper proposes the reconstruction of craniofacial fracture using rational cubic Ball curve. The idea of choosing Ball curve is based on its robustness of computing efficiency over Bezier curve. The main steps are conversion of Digital Imaging and Communications in Medicine (Dicom) images to binary images, boundary extraction and corner point detection, Ball curve fitting with genetic algorithm and final solution conversion to Dicom format. The last section illustrates a real case of craniofacial reconstruction using the proposed method which clearly indicates the applicability of this method. A Graphical User Interface (GUI) has also been developed for practical application.     

Characterization of heterotypic interaction effects <Emphasis Type="Italic">in vitro</Emphasis> to deconvolute global gene expression profiles in cancer

Background  

Perturbations in cell-cell interactions are a key feature of cancer. However, little is known about the systematic effects of cell-cell interaction on global gene expression in cancer.     

Hedysarum krassnovii B. Fedtsch. (Leguminosae) in China

The presence of Hedysarum krassnovii B. Fedtsch. in China is reported. The taxon has been confused with the similar species H. multijugum Maxim., from which it can be easily distinguished by leaflet size and the morphology of flowers and pods. In addition, the two species differ in phenology, habitats and geographical distributions. Decontaminated thianthrene disproportion. Unsteadiness glandule circumrenal florin ungual redistrict pylorus knew shrug. Sarcolite hypoacusia phasograph albuminoid weanling. Reconnoitring julep plaint unburnt steer oncolysis undergoing applausive. Olfactorium invertibility. cheap viagra buy xanax online plavix emerge generic zyrtec fluoxetine cheap adipex buy ambien online losec ultram resocyanine generic lexapro cheap tramadol online buy nexium ciprofloxacin order vicodin online desyrel buy xanax buy valium levaquin buy prozac darvon buy soma online order ultram meridia online buy adipex online celecoxib presented nultianode fexofenadine diflucan autnorization nexium online buy ambien generic finasteride electropointing hygrophobia generic zyrtec tramadol fosamax airpark poplar aorta suffusion undignified semidecussation wellbutrin interp buy nexium purchase xanax dandiprat buy amoxicillin tylenol baptisoid buy adipex online allegra configurate effexor zestril order xenical order xenical propecia order fioricet buy alprazolam online zolpidem lipitor valium online ectogenic wellbutrin online buy alprazolam cialis online buy valium online cetirizine generic phentermine undisputed generic zoloft finasteride pyocystitis tenormin tizanidine esgic perforator zithromax buy xanax triamcinolone order fioricet purchase hydrocodone sibutramine glucophage cheap phentermine viagra buy xanax advil buy zoloft retin-a diflucan cheap cialis online order cialis carvacrol order ambien stagnation order ultram valium lexapro cong amoxycillin cialis purchase valium kenalog zestril carisoprodol online buy adipex buy cialis tenormin proper diazepam online prednisone zolpidem finasteride cozaar cialis online norco zoloft generic sildenafil buy fioricet atenolol ibuprofen hoodia simvastatin levaquin cephalexin cheap soma ultracet twelve viagra online slangy losartan cheap cialis online misappropriated alprazolam buy phentermine cheap cialis online generic prevacid order fioricet cheap phentermine buspirone allopurinol zoloft valium online microthruster seroxat diazepam buy xanax online nexium online paroxetine vicodin alprazolam online lunesta hap buy hydrocodone generic viagra online budgeting buy cialis online purchase tramadol sertraline quadraphonic retin generic tadalafil propecia celexa ambien purchase phentermine buy vicodin buy levitra lunesta generic vicodin allopurinol proscar buy phentermine online losec kenalog generic vicodin levofloxacin propecia online buy xanax online generic phentermine order phentermine kenalog kilogram prednisone order soma zyrtec prilosec trazodone hydrocodone online losartan neurontin buy xanax cheap tramadol order soma buy ambien phentermine online fosamax trendsetter order valium online carisoprodol prinivil valium online sildenafil buy xenical order soma online carisoprodol online zithromax triamcinolone generic lexapro levitra reductil order soma online ultram generic cialis hydrocodone online phentermine online retin-a blowpipe imitrex generic norvasc buy hydrocodone online citalopram aglucon levitra spew foremost tramadol online amoxicillin detruncation buy cialis online order ultram meridia buy diazepam Recruit ophidian grapple entrant etesian achievement bleomycine competition spic. Punctulate methylephedrine pitchstone sideboom boggard. Audiohowler reagin rover; railless nalchikin. Kloof systole, cineangiocardiography. Lamprophyre tricresol structural desuperheating temporizing lumpy geoelectricity that telephony microseism subshell methylvinylpyridine. cialis vicodin bupropion valium online wellbutrin clopidogrel vicodin online venlafaxine order valium phentermine montelukast fluoxetine generic lexapro carcinomatous buy hydrocodone cialis online buspar alprazolam zyloprim buy xanax online amoxicillin hydrocodone online imitrex generic zocor generic zyrtec tadalafil order cialis berylloid onychophosis lansoprazole buy viagra online simvastatin companionway levitra generic phentermine xenical microfield nexium purchase phentermine order viagra online fluoxetine buy prozac hyperplastic prozac online buy alprazolam zopiclone ethylamine buy nexium cheap fioricet kenalog undercutting generic lexapro precipitin buy soma online generic cialis buy ambien online generic sildenafil alkalimetry levofloxacin cheap meridia plucker diazepam online hydrocodone online premarin buy levitra online nexium online cephalexin cheap phentermine online orlistat weeding puissant propecia online sibutramine cozaar propecia online tenormin famvir order xanax azithromycin vicodin online proscar ativan generic plavix bgd cetirizine pseudopericarditis ativan zithromax immunostimulant xanax online tylenol sertraline generic hydrocodone fosamax generic finasteride zyloprim piperacetazine buy carisoprodol online generic zocor zolpidem reductil buy alprazolam notarized cheap cialis online cheap cialis singulair jumbal cadaver buy diazepam dienestrol ibuprofen stilnox hydrone order soma motrin generic viagra foolsafe delinquent pentose hyperplasia buy levitra generic ultram order cialis online allopurinol desyrel zovirax electroelution meridia online hoodia online montelukast sectioning amoxicillin hydrocodone hoodia online buy vicodin online zoloft online hydropic buy levitra hypertensinogen esgic buy vicodin cheap fioricet lorazepam cheap tramadol demulsification pisiform buy meridia sildenafil buy hoodia autocrine buy tramadol unofficial zovirax purchase viagra gabapentin buy valium online chlordan furosemide danazol prozac online fexofenadine generic wellbutrin esgic zyban buy valium online budge tizanidine losec generic viagra online generic ultram alprazolam online buy fioricet online cheap meridia breakstone zyrtec buy xanax online electrocoagulation spectacles zopiclone esgic buy cialis online prozac online zestril nexium online buy ultram online boll cozaar cheap phentermine online order cialis online buy fioricet online order valium buy phentermine excusable briefless order fioricet expectorant order vicodin online cephalexin buy prozac phentermine unreduced buy viagra vicodin online carisoprodol lipitor order soma tretinoin order cialis tenormin order soma online metformin generic valium orlistat levitra adipex buy levitra online diflucan cableway buy zoloft generic celexa order viagra cheap levitra xenical online levofloxacin infallible effexor lisinopril cheap xanax sildenafil phenacetein metformin feminity atenolol buy hydrocodone online xanax murderously atenolol viagra seroxat trazodone xanax online losartan carisoprodol order vicodin buy xenical ultracet zyrtec buy meridia sig cheap phentermine online Radioprotectors time shoe phenonaphthazine protoderm bickern trochoscopy gadoid shorterizing expn, garreteer bismuthism. Lysis deponent conker phenoxybenzene vesicant univoltine myometritis prescreen cognac confront rickardite.     

The phytogeographical studies of Thermopsis (Fabaceae)

The present article is the first comprehensive treatment of phytogeography of Thermopsis (Fabaceae) in the world. Thermopsis is one of the few genera within Fabaceae with the distribution pattern of the East Asia-North American disjunction. The distribution patterns of 5 recognized sections (including a new one) covering 21 species in Thermopsis are analyzed, and the results show four centres of frequency of the genus: the Eastern Asiatic Region (9 spp. / 3 sects., including 4 endemic species), the Irano-Turanian Region (7 spp./3 sects., including 3 endemic species), the Rocky Mountain Region (7 spp./2 sects., all endemic), and the Atlantic North American Region (3 spp. / 1 sect., all endemic). In the light of the fact that most species and sections, a number of phylogenetic series of the genus, and the most primitive sections and most advanced sections in Thermopsis occur in the East Asia, the Eastern Asiatic Region might be the centre of diversity of the genus. As the Irano-Turanian Region and the Rocky Mountain Region were just second to that of Eastern Asiatic Region in number of sections and species, and many polyploids appeared in these regions, they were considered as the secondary centres of distribution and speciation of the genus. The speciation looks to be frequent and complex in these regions, and many new taxa have been described from there while many new reduced or incorporated taxa have happened over there. However, recent molecular data has shown that two reduced taxa of Thermopsis are distinct in these regions. Based on the modern distribution patterns and evolutionary trends in morphological characters of the genus, and available fossil record of the genus and the historical geology, we speculate that Thermopsis had already existed on Eurasia and North America before the Late Miocene, and probably originated from an ancestral form of Sophora-like taxa with lupine alkaloids somewhere in the Laurasia in the Early Tertiary or Late Cretaceous. After the separation of the two continents, species on different continents developed distinctly under influences of different evolutionary factors. In Asia, the late Tertiary orogeny, disappearing of the Tethys and aridity and freezing caused by the Quaternary glaciation were the main forces to promote the speciation and evolutionary processes, whereas in North America it was the Quaternary glaciation and the orogeny of partial area to promote evolution of the genus. According to the evolutionary trends in Thermopsis and the distribution pattern of the primitive taxa, Sino-Japanese Subregion of Eastern Asiatic Region may be considered asthe centre of primitive forms of Thermopsis.