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排序方式: 共有2096条查询结果,搜索用时 820 毫秒
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Magdalena Kaliszewska Jakub Kruszewski Biruta Kierdaszuk Anna Kostera-Pruszczyk Monika Nojszewska Anna Łusakowska Joel Vizueta Dorota Sabat Dorota Lutyk Michał Lower Dorota Piekutowska-Abramczuk Aneta Kaniak-Golik Ewa Pronicka Anna Kamińska Ewa Bartnik Paweł Golik Katarzyna Tońska 《Human genetics》2015,134(9):951-966
994.
Discrete population models which assume unequal resource partitioning among population members bring about population stability. These models also assume that individual resource share is independent of population density. The model presented here is an attempt to answer the question What does bring about population stability—the inequality of resource partitioning itself or the independence of resource share of population density? By developing a theoretical model with varying dependence of the resource share on the population size, it is shown that the inequality itself is not sufficient for population stability; rather it is the independence of the resource share from population size which brings about this property. 相似文献
995.
Daniel Bennett Stefan Bode Maja Brydevall Hayley Warren Carsten Murawski 《PLoS computational biology》2016,12(7)
In a dynamic world, an accurate model of the environment is vital for survival, and agents ought regularly to seek out new information with which to update their world models. This aspect of behaviour is not captured well by classical theories of decision making, and the cognitive mechanisms of information seeking are poorly understood. In particular, it is not known whether information is valued only for its instrumental use, or whether humans also assign it a non-instrumental intrinsic value. To address this question, the present study assessed preference for non-instrumental information among 80 healthy participants in two experiments. Participants performed a novel information preference task in which they could choose to pay a monetary cost to receive advance information about the outcome of a monetary lottery. Importantly, acquiring information did not alter lottery outcome probabilities. We found that participants were willing to incur considerable monetary costs to acquire payoff-irrelevant information about the lottery outcome. This behaviour was well explained by a computational cognitive model in which information preference resulted from aversion to temporally prolonged uncertainty. These results strongly suggest that humans assign an intrinsic value to information in a manner inconsistent with normative accounts of decision making under uncertainty. This intrinsic value may be associated with adaptive behaviour in real-world environments by producing a bias towards exploratory and information-seeking behaviour. 相似文献
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997.
Morphological changes and phenolic patterns of developing hellebore sepals and the effects of pistil removal on these parameters were studied by comparing six flower stages of Helleborus niger. Color changes were evaluated colorimetrically, chlorophyll content was measured spectrophotometrically, and anthocyanins and flavonols were identified and quantified with HPLC–MS. Pistil removal not only altered the morphological development of hellebore flower resulting in smaller flower and significant color changes but also lead to several biochemical modifications. Five cyanidin glycosides have been identified from the group of anthocyanins in hellebore. Individual and total anthocyanin content increased from bud to subsequent developmental stages. Moreover, significantly higher content levels of individual and total anthocyanins have been measured in non-pollinated flower sepals compared to sepals of pollinated flowers. From the group of flavonols eight quercetin and kaempferol compounds have been quantified in hellebore sepals. Flavonol content significantly decreased during flower development with lowest levels recorded in sepals of non-pollinated and senescent pollinated hellebore flowers. Sepals of pollinated flowers contained highest levels of chlorophyll and significantly lower amounts of chlorophyll were measured in non-pollinated flowers and in sepals of senescent stage. 相似文献
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Charlotte C. Gupta Jill Dorrian Crystal L. Grant Maja Pajcin Alison M. Coates David J. Kennaway 《Chronobiology international》2017,34(1):66-77
Shiftworkers have impaired performance when driving at night and they also alter their eating patterns during nightshifts. However, it is unknown whether driving at night is influenced by the timing of eating. This study aims to explore the effects of timing of eating on simulated driving performance across four simulated nightshifts. Healthy, non-shiftworking males aged 18–35 years (n = 10) were allocated to either an eating at night (n = 5) or no eating at night (n = 5) condition. During the simulated nightshifts at 1730, 2030 and 0300 h, participants performed a 40-min driving simulation, 3-min Psychomotor Vigilance Task (PVT-B), and recorded their ratings of sleepiness on a subjective scale. Participants had a 6-h sleep opportunity during the day (1000–1600 h). Total 24-h food intake was consistent across groups; however, those in the eating at night condition ate a large meal (30% of 24-h intake) during the nightshift at 0130 h. It was found that participants in both conditions experienced increased sleepiness and PVT-B impairments at 0300 h compared to 1730 and 2030 h (p < 0.001). Further, at 0300 h, those in the eating condition displayed a significant decrease in time spent in the safe zone (p < 0.05; percentage of time within 10 km/h of the speed limit and 0.8 m of the centre of the lane) and significant increases in speed variability (p < 0.001), subjective sleepiness (p < 0.01) and number of crashes (p < 0.01) compared to those in the no eating condition. Results suggest that, for optimal performance, shiftworkers should consider restricting food intake during the night. 相似文献
1000.
Kovarik Z Calić M Sinko G Bosak A Berend S Vrdoljak AL Radić B 《Chemico-biological interactions》2008,175(1-3):173-179
One of the therapeutic approaches to organophosphate poisoning is to reactivate AChE with site-directed nucleophiles such as oximes. However, pyridinium oximes 2-PAM, HI-6, TMB-4 and obidoxime, found as the most effective reactivators, have limiting reactivating potency in tabun poisoning. We tested oximes varying in the type of ring (pyridinium and/or imidazolium), the length and type of the linker between rings, and in the position of the oxime group on the ring to find more effective oximes to reactivate tabun-inhibited human erythrocyte AChE. Three of our tested pyridinium oximes K027, K048, K074, along with TMB-4, were the most promising for AChE reactivation. Promising oximes were further tested in vivo on tabun poisoned mice not only as antidotes in combination with atropine but also as pretreatment drug. Herein, we showed that a promising treatment in tabun poisoning by selected oximes and atropine could be improved if oximes are also used in pretreatment. Since the reactivating efficacy of the oximes in vitro corresponded to their therapeutic efficacy in vivo, it seems that pharmacological effect of these oximes is indeed primarily related to the reactivation of tabun-phosphorylated AChE. 相似文献