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521.
Ghada Kchour SA Rahim Rezaee Reza Farid Akram Ghantous Houshang Rafatpana Mahdi Tarhini Mohamad-Mehdi Kooshyar Hiba El Hajj Fadwa Berry Roudaina Nasser Abbas Shirdel Zeina Dassouki Mohamad Ezzedine Hossein Rahimi Ardeshir Ghavamzadeh Hugues de Thé Olivier Hermine Mahmoud Mahmoudi Ali Bazarbachi 《Retrovirology》2014,11(Z1):O4
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Background
Despite the impact of sodium valproate and dexamethasone on migraine headache, the efficacy of the two drugs has not been properly investigated and compared. This trial compared the effect of the two drugs on acute migraine headache.Methods
This double blind randomized clinical trial was conducted on patients aged 18 to 65 years with acute migraine headache who referred to the emergency departments of Beasat and Farshchian Hospitals in Hamadan, Iran, from April 2012 to June 2014. Patients were randomly assigned to receive a single-dose of either 400 mg sodium valproate or 16 mg dexamethasone plus 50 ml saline normal solution within 15 min intravenously. The severity of headache in the two groups was evaluated at baseline, 0.5 and 2 hours later using the Visual Analog Scale (VAS) on a scale of 0 to 10.Results
Of 104 patients enrolled, 72 patients remained for analysis. The effect of both sodium valproate and dexamethasone on acute migraine headache was statistically significant at 0.5 and 2 hours post-treatment compared to pre-treatment (P=0.001). The severity of headache based on VAS reduced form 8.20 (7.72, 8.68) before treatment to 5.31 (4.74, 5.89) and 3.66 (2.99, 4.33) at 0.5 and 2 hours after treatment, respectively, in patients receiving sodium valproate and from 8.46 (8.05, 8.86) before treatment to 5.46 (4.81, 6.11) and 3.59 (2.84, 4.35) at 0.5 and 2 hours after treatment, respectively, in patients receiving dexamethasone. Both drugs were highly effective in improvement of acute headache in patients without aura. However, sodium valproate significantly improved the acute headache in patients with aura but dexamethasone did not. The severity of headache based on VAS reduced form 8.50 (7.40, 9.60) before treatment to 4.67 (2.40, 6.93) and 3.50 (1.78, 5.22) at 0.5 and 2 hours after treatment, respectively, in patients with aura receiving sodium valproate and from 8.80 (7.76, 9.84) before treatment to 7.20 (4.98, 9.42) and 6.20 (2.43, 9.97) at 0.5 and 2 hours after treatment, respectively, in patients with aura receiving dexamethasone.Conclusions
This trial indicated that, in overall, intravenous sodium valproate is not superior to intravenous dexamethasone in treatment of acute migraine attacks. However, in patients with aura, only sodium valproate but not dexamethasone is effective in headache relief. This issue needs further investigations.Trial Registration
ClinicalTrials.gov IRCT201202199014N1 相似文献524.
525.
According to recent researches, angle shear connectors are appropriate to transfer longitudinal shear forces across the steel-concrete interface. Angle steel profile has been used in different positions as L-shaped or C-shaped shear connectors. The application of angle shear connectors in tilted positions is of interest in this study. This study investigates the behaviour of tilted-shaped angle shear connectors under monotonic loading using experimental push out tests. Eight push-out specimens are tested to investigate the effects of different angle parameters on the ultimate load capacity of connectors. Two different tilted angles of 112.5 and 135 degrees between the angle leg and steel beam are considered. In addition, angle sizes and lengths are varied. Two different failure modes were observed consisting of concrete crushing-splitting and connector fracture. By increasing the size of connector, the maximum load increased for most cases. In general, the 135 degrees tilted angle shear connectors have a higher strength and stiffness than the 112.5 degrees type. 相似文献
526.
Mohamad Hosein Aghajani Ali Mahmoud Pashazadeh Seyed Hossein Mostafavi Shayan Abbasi Mohammad-Javad Hajibagheri-Fard Majid Assadi Mahdi Aghajani 《AAPS PharmSciTech》2015,16(5):1059-1068
In this study, nanosuspension of stable iodine (127I) was prepared by nanoprecipitation process in microfluidic devices. Then, size of particles was optimized using artificial neural networks (ANNs) modeling. The size of prepared particles was evaluated by dynamic light scattering. The response surfaces obtained from ANNs model illustrated the determining effect of input variables (solvent and antisolvent flow rate, surfactant concentration, and solvent temperature) on the output variable (nanoparticle size). Comparing the 3D graphs revealed that solvent and antisolvent flow rate had reverse relation with size of nanoparticles. Also, those graphs indicated that the solvent temperature at low values had an indirect relation with size of stable iodine (127I) nanoparticles, while at the high values, a direct relation was observed. In addition, it was found that the effect of surfactant concentration on particle size in the nanosuspension of stable iodine (127I) was depended on the solvent temperature.
Graphical Abstract
Open in a separate windowNanoprecipitation process of stable iodine (127I) and optimization of particle size using ANNs modeling.KEY WORDS: ANNs, microfluidic, nanoprecipitation, particle size, stable iodine 相似文献527.
Médéric Jeanne Hélène Demory Aubin Moutal Marie-Laure Vuillaume Sophie Blesson Rose-Anne Thépault Sylviane Marouillat Judith Halewa Saskia M. Maas M. Mahdi Motazacker Grazia M.S. Mancini Marjon A. van Slegtenhorst Avgi Andreou Helene Cox Julie Vogt Jason Laufman Natella Kostandyan Davit Babikyan Frédéric Laumonnier 《American journal of human genetics》2021,108(5):951-961
528.
Riad Al-Kasasbeh Nikolay Korenevskiy Florin Ionescou Mahdi Alshamasin Alexander Kuzmin 《Computer methods in biomechanics and biomedical engineering》2013,16(7):681-689
Many theories of reflexology use ancient concepts which do not coincide with the modern medical terminology of anatomy, physiology and biophysics. This substantially reduces the trust of physicians in reflexology methods. During this research, several mathematical models for the interaction of the internal and biological active points of meridian structures have been proposed. The analysis of these models allows the specification of a list of heart diseases for which reflex diagnostics and reflex therapy methods are most effective and also allows increasing the effectiveness of these procedures. It is shown that good results for the prediction and early diagnosis of diseases from the reaction energy of biologically active points (acupuncture points) are obtained using fuzzy logic decision making. 相似文献
529.
Riad Al-Kasasbeh Nikolay Korenevskiy Mahdi Alshamasin Florin Ionescou Andrew Smith 《Computer methods in biomechanics and biomedical engineering》2013,16(3):302-313
Many theories of reflexology use ancient concepts which do not coincide with the modern medical terminology of anatomy, physiology and biophysics. This substantially reduces the trust of physicians in reflexology methods. During this research, several mathematical models for the interaction of the internal and biological active points of meridian structures have been proposed. The analysis of these models allows the specification of a list of gastric diseases for which reflex diagnostics and reflex therapy methods are most effective and also allows increasing the effectiveness of these procedures. It is shown that good results for the prediction and early diagnosis of diseases from the reaction energy of biologically active points (acupuncture points) are obtained using fuzzy logic decision making. 相似文献
530.