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161.
Deepti Lall Ileana Lorenzini Thomas A. Mota Shaughn Bell Thomas E. Mahan Jason D. Ulrich Hayk Davtyan Jessica E. Rexach A.K.M. Ghulam Muhammad Oksana Shelest Jesse Landeros Michael Vazquez Junwon Kim Layla Ghaffari Jacqueline Gire O’Rourke Daniel H. Geschwind Mathew Blurton-Jones David M. Holtzman Robert H. Baloh 《Neuron》2021,109(14):2275-2291.e8
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Adenocarcinoma of the prostate is responsible for one of every nine deaths from cancer in Canada. In this review epidemiologic factors are considered and current staging systems are outlined. The American Urological System is recommended for staging because of its ability to reflect changes in the understanding of the biologic behaviour of this neoplasm. The adoption of a quantitative grading scheme is suggested to complement the information obtained from the staging assessment. The routes of spread of this disease, along with the procedures used to assess metastatic involvement, are described. Immunologic methods for the analysis of prostatic acid phosphatase have been shown to be superior to the enzymatic methods previously used, and the role of the new techniques is discussed. Emphasis is placed on radiotherapy and endocrine therapy for the treatment of this neoplasm, and the concept of withholding endocrine therapy until symptoms appear is discussed. Potential future developments in this field are considered. 相似文献
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Sequence and functional differences between Schmidt-Ruppin D and Schmidt-Ruppin A strains of pp60v-src. 总被引:1,自引:0,他引:1
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We show that Schmidt-Ruppin D pp60v-src kinase activity is reduced by a mutation previously shown to be associated with Schmidt-Ruppin A pp60v-src temperature sensitivity and that its reduced transforming activity is associated with a conformational change in the SH3 region. The evolutionary relationship of seven v-src strains was studied by using parsimony analysis. 相似文献