Comparative Studies on Some Isolates of Rhizoctonia solani in Egypt

Nine isolates of Rhizoctonia solani from various hosts were selected for this study. The isolates were tested for their compatibility by an anastomosis test. Isolates were classified into two Egyptian anastomosis groups (EAG-1 and EAG-2). The isolates varied in virulence, thiamine requirement and quality and quantity of free and protein amino acids.     

A Loop Material Flow System Design for Automated Guided Vehicles

We develop an exact integer programming formulation to design a loop material flow system for unit-load automated guided vehicles. The model simultaneously determines both the design of the unidirectional loop flow pattern and the location of the pickup and delivery stations. The objective is to minimize the total loaded-vehicle trip distances. To solve the problem, we concentrate on developing a better formulation for the LP subproblem, preprocessing the problem, identifying the appropriate set of LP/IP routines, analyzing the mathematical properties of the problem, and developing an intelligent branch and bound solution procedure.     

Preliminary studies on the use of biochemical and physiological tests for the characterization of Fusarium isolates

Twenty-two isolates of Fusarium were examined for their ability to grow on a range of carbon sources, resistance to inhibitory chemicals, and their API ZYM enzyme profiles. Growth on common carbon sources showed little discrimination between isolates, but they could be differentiated on the basis of their enzymic activity and tolerance to inhibitors, particularly copper sulphate and malachite green.     

Synthesis of some quinazolinones inspired from the natural alkaloid L-norephedrine as EGFR inhibitors and radiosensitizers

A set of quinazolinones synthesized by the aid of L-norephedrine was assembled to generate novel analogues as potential anticancer and radiosensitizing agents. The new compounds were evaluated for their cytotoxic activity against MDA-MB-231, MCF-7, HepG-2, HCT-116 cancer cell lines and EGFR inhibitory activity. The most active compounds 5 and 6 were screened against MCF-10A normal cell line and displayed lower toxic effects. They proved their relative safety with high selectivity towards MDA-MB-231 breast cancer cell line. Measurement of the radiosensitizing activity for 5 and 6 revealed that they could sensitize the tumour cells after being exposed to a single dose of 8 Gy gamma radiation. Compound 5 was able to induce apoptosis and arrest the cell cycle at the G2-M phase. Molecular docking of 5 and 6 in the active site of EGFR was performed to gain insight into the binding interactions with the key amino acids.     

Synthesis and Anticancer Activity Evaluation of Some Thienopyrimidine Derivatives

Russian Journal of Bioorganic Chemistry - The current study focused on effective and straightforward routes for preparing a new series of thieno[2,3-d]pyrimidine derivatives in addition to their...