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921.
922.
923.
We discuss a diversity measure combining information of relative abundances and taxonomic distinctiveness suggested by Ricotta (2004). We show that Ricotta's measure violates weak species monotonicity, a condition that requires that the addition of a species should always increase a diversity index if abundances change only marginally. We suggest an alternative index satisfying weak species monotonicity and apply it to the 'Zeesserveld' forest reserve in the Netherlands. 相似文献
924.
Jacoba M. Spikman Maarten V. Milders Annemarie C. Visser-Keizer Herma J. Westerhof-Evers Meike Herben-Dekker Joukje van der Naalt 《PloS one》2013,8(6)
Traumatic brain injury (TBI) is a leading cause of disability, specifically among younger adults. Behavioral changes are common after moderate to severe TBI and have adverse consequences for social and vocational functioning. It is hypothesized that deficits in social cognition, including facial affect recognition, might underlie these behavioral changes. Measurement of behavioral deficits is complicated, because the rating scales used rely on subjective judgement, often lack specificity and many patients provide unrealistically positive reports of their functioning due to impaired self-awareness. Accordingly, it is important to find performance based tests that allow objective and early identification of these problems. In the present study 51 moderate to severe TBI patients in the sub-acute and chronic stage were assessed with a test for emotion recognition (FEEST) and a questionnaire for behavioral problems (DEX) with a self and proxy rated version. Patients performed worse on the total score and on the negative emotion subscores of the FEEST than a matched group of 31 healthy controls. Patients also exhibited significantly more behavioral problems on both the DEX self and proxy rated version, but proxy ratings revealed more severe problems. No significant correlation was found between FEEST scores and DEX self ratings. However, impaired emotion recognition in the patients, and in particular of Sadness and Anger, was significantly correlated with behavioral problems as rated by proxies and with impaired self-awareness. This is the first study to find these associations, strengthening the proposed recognition of social signals as a condition for adequate social functioning. Hence, deficits in emotion recognition can be conceived as markers for behavioral problems and lack of insight in TBI patients. This finding is also of clinical importance since, unlike behavioral problems, emotion recognition can be objectively measured early after injury, allowing for early detection and treatment of these problems. 相似文献
925.
926.
Many species show large variation in lifetime reproductive success (LRS), with a few individuals producing the majority of offspring. This variation can be explained by factors related to individuals (fixed heterogeneity) and stochastic differences in survival and reproduction (dynamic heterogeneity). In this study, we study the relative effects of these processes on the LRS of a Dutch Kestrel population, using three different methods. First, we extended neutral simulations by simulating LRS distributions of populations consisting of groups with increasingly different population parameters. Decomposition of total LRS variance into contributions from fixed and dynamic heterogeneity revealed that the proportion of fixed heterogeneity is probably lower than 10% of the total variance. Secondly, we used sensitivities of the mean and variance in LRS to each parameter to analytically show that it is impossible to get equal contributions of fixed and dynamic heterogeneity when only one parameter differs between groups. Finally, we computed the LRS probability distribution to show that even when all individuals have identical survival and reproduction rates, the variance in LRS is large (females: 27.52, males: 12.99). Although each method has its limitations, they all lead to the conclusion that the majority of the variation in kestrel LRS is caused by dynamic heterogeneity. This large effect of dynamic heterogeneity on LRS is similar to results for other species and contributes to the evidence that in most species the majority of individual variation in LRS is due to dynamic heterogeneity. 相似文献
927.
Hydrobiologia - The Lake Edward system in Eastern Central Africa, including Lakes Edward and George and their associated rivers, is home to a species assemblage of endemic haplochromine cichlids.... 相似文献
928.
Stephen?R.F. Twigg Jennifer Forecki Jacqueline?A.C. Goos Ivy?C.A. Richardson A.?Jeannette?M. Hoogeboom Ans?M.W. van?den?Ouweland Sigrid?M.A. Swagemakers Maarten?H. Lequin Daniel Van?Antwerp Simon?J. McGowan Isabelle Westbury Kerry?A. Miller Steven?A. Wall WGS Consortium Peter?J. van?der?Spek Irene?M.J. Mathijssen Erwin Pauws Christa?S. Merzdorf Andrew?O.M. Wilkie 《American journal of human genetics》2015,97(3):378-388
929.
Verena Boschert Maarten van Dinther Stella Weidauer Katharina van Pee Eva-Maria Muth Peter ten Dijke Thomas D. Mueller 《PloS one》2013,8(11)
The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and therefore represents a promising therapeutic target. It exerts its biological task by inhibiting the Wnt (wingless and int1) signaling pathway, which participates in bone formation by promoting the differentiation of mesenchymal stem cells to osteoblasts. The core structure of Sclerostin consists of three loops with the first and third loop (Finger 1 and Finger 2) forming a structured β-sheet and the second loop being unstructured and highly flexible. Biochemical data showed that the flexible loop is important for binding of Sclerostin to Wnt co-receptors of the low-density lipoprotein related-protein family (LRP), by interacting with the Wnt co-receptors LRP5 or -6 it inhibits Wnt signaling. To further examine the structural requirements for Wnt inhibition, we performed an extensive mutational study within all three loops of the Sclerostin core domain involving single and multiple mutations as well as truncation of important regions. By this approach we could confirm the importance of the second loop and especially of amino acids Asn92 and Ile94 for binding to LRP6. Based on a Sclerostin variant found in a Turkish family suffering from Sclerosteosis we generated a Sclerostin mutant with cysteines 84 and 142 exchanged thereby removing the third disulfide bond of the cystine-knot. This mutant binds to LRP6 with reduced binding affinity and also exhibits a strongly reduced inhibitory activity against Wnt1 thereby showing that also elements outside the flexible loop are important for inhibition of Wnt by Sclerostin. Additionally, we examined the effect of the mutations on the inhibition of two different Wnt proteins, Wnt3a and Wnt1. We could detect clear differences in the inhibition of these proteins, suggesting that the mechanism by which Sclerostin antagonizes Wnt1 and Wnt3a is fundamentally different. 相似文献
930.
Bistability and regular spatial patterns in arid ecosystems 总被引:1,自引:0,他引:1
Sonia Kéfi Maarten B. Eppinga Peter C. de Ruiter Max Rietkerk 《Theoretical Ecology》2010,3(4):257-269
A variety of patterns observed in ecosystems can be explained by resource–concentration mechanisms. A resource–concentration
mechanism occurs when organisms increase the lateral flow of a resource toward them, leading to a local concentration of this
resource and to its depletion from areas farther away. In resource–concentration systems, it has been proposed that certain
spatial patterns could indicate proximity to discontinuous transitions where an ecosystem abruptly shifts from one stable
state to another. Here, we test this hypothesis using a model of vegetation dynamics in arid ecosystems. In this model, a
resource–concentration mechanism drives a positive feedback between vegetation and soil water availability. We derived the
conditions leading to bistability and pattern formation. Our analysis revealed that bistability and regular pattern formation
are linked in our model. This means that, when regular vegetation patterns occur, they indicate that the system is along a
discontinuous transition to desertification. Yet, in real systems, only observing regular vegetation patterns without identifying
the pattern-driving mechanism might not be enough to conclude that an ecosystem is along a discontinuous transition because
similar patterns can emerge from different ecological mechanisms. 相似文献