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STUART B. PIERTNEY REW D.C. MacCOLL XAVIER LAMBIN ROBERT MOSS JOHN F. DALLAS 《Biological journal of the Linnean Society. Linnean Society of London》1999,68(1-2):317-331
Several aspects of the ecology and biology of red grouse (Lagopus lagopus scoticus) could prevent the complete admixture of genes within and between populations. Male red grouse display a high degree of natal philopatry, are territorial, and show less aggression to kin man to non-kin. Such factors acting in combination predict limited male-mediated gene flow, which will promote social structure within a population by the formation of stable kin clusters, and facilitate a rapid rise in allelic coancestry and/or inbreeding. In this study we utilize hypervariable microsatellite polymorphisms to examine the extent of social affiliation between relatives in a moorland population of grouse from NE Scodand. Levels of genetic relatedness between individual male red grouse occupying territories at Glas Choille in die spring and autumn of 1995 were examined, and kin clusters delimited. Nine kin groups (mean size = 2.4 individuals) were identified prior to breeding in the spring, which increased to 11 kin groups (mean size =4.0 individuals) when territories were reformed in the autumn. The majority of tiiose individuals that were recruited into the adult population during the autumn already had a first-order male relative established, supporting the hypothesis that recruitment is facilitated by behavioural interactions among relatives. The demographic and population genetic consequences of philopatric recruitment and kin clustering are examined and discussed. 相似文献
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David Gendron Anne-Marie Lemay Claudine Tremblay Laetitia JA Lai Anick Langlois émilie Bernatchez Nicolas Flamand Marie-Renée Blanchet Anthony S Don Ynuk Bossé élyse Bissonnette David Marsolais 《Respiratory research》2015,16(1)
Background
In vivo phosphorylation of sphingosine analogs with their ensuing binding and activation of their cell-surface sphingosine-1-phosphate receptors is regarded as the main immunomodulatory mechanism of this new class of drugs. Prophylactic treatment with sphingosine analogs interferes with experimental asthma by impeding the migration of dendritic cells to draining lymph nodes. However, whether these drugs can also alleviate allergic airway inflammation after its onset remains to be determined. Herein, we investigated to which extent and by which mechanisms the sphingosine analog AAL-R interferes with key features of asthma in a murine model during ongoing allergic inflammation induced by Dermatophagoides pteronyssinus.Methods
BALB/c mice were exposed to either D. pteronyssinus or saline, intranasally, once-daily for 10 consecutive days. Mice were treated intratracheally with either AAL-R, its pre-phosphorylated form AFD-R, or the vehicle before every allergen challenge over the last four days, i.e. after the onset of allergic airway inflammation. On day 11, airway responsiveness to methacholine was measured; inflammatory cells and cytokines were quantified in the airways; and the numbers and/or viability of T cells, B cells and dendritic cells were assessed in the lungs and draining lymph nodes.Results
AAL-R decreased airway hyperresponsiveness induced by D. pteronyssinus by nearly 70%. This was associated with a strong reduction of IL-5 and IL-13 levels in the airways and with a decreased eosinophilic response. Notably, the lung CD4+ T cells were almost entirely eliminated by AAL-R, which concurred with enhanced apoptosis/necrosis in that cell population. This inhibition occurred in the absence of dendritic cell number modulation in draining lymph nodes. On the other hand, the pre-phosphorylated form AFD-R, which preferentially acts on cell-surface sphingosine-1-phosphate receptors, was relatively impotent at enhancing cell death, which led to a less efficient control of T cell and eosinophil responses in the lungs.Conclusion
Airway delivery of the non-phosphorylated sphingosine analog, but not its pre-phosphorylated counterpart, is highly efficient at controlling the local T cell response after the onset of allergic airway inflammation. The mechanism appears to involve local induction of lymphocyte apoptosis/necrosis, while mildly affecting dendritic cell and T cell accumulation in draining lymph nodes. 相似文献45.
The invasive freshwater snail Tarebia granifera (Lamarck, 1822) was first reported in South Africa in 1999 and it has become widespread across the country, with some evidence to suggest that it reduces benthic macroinvertebrate biodiversity. The current study aimed to identify the primary abiotic drivers behind abundance patterns of T. granifera, by comparing the current abundance of the snail in three different regions, and at three depths, of the highly modified Nseleni River in KwaZulu-Natal, South Africa. Tarebia granifera was well established throughout the Nseleni River system, with an overall preference for shallow waters and seasonal temporal patterns of abundance. Although it is uncertain what the ecological impacts of the snail in this system are, its high abundances suggest that it should be controlled where possible and prevented from invading other systems in the region. 相似文献
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Small amounts (5.6 or n-2 kg a.i./ha) of aldicarb or oxamyl, incorporated in the soil before potatoes were planted in spring, controlled potato cyst-nematodes (Heterodera rostochiensis and H. pallida) on susceptible cultivars equally well in sandy, peaty and silt loam soils. In soils treated with either nematicide, nematode numbers increased little or decreased; in untreated soils nematode numbers increased greatly. In contrast organophosphate nematicides, similarly applied, fenamiphos (proposed BSI common name for O-ethyl-O-(3-methyl-4-methylthiophenyI)-isopropylamido-phosphate), ethoprophos (proposed BSI common name for (O-ethyl S, 5-dipropyl phos-phorodithioate), CGA 12223 (O, O-diethyl O-[i-isopropyl-5-chloro-i,2,4-triazoIyl-(3)] phosphorothioate) and Dowco 275 (O, O-diethyl O-(6-fluoro-2 pyridyl) phosphorothioate), were ineffective at one or more of the experimental sites. Potato yields were greatly increased by oximecarbamate or organophosphate nematicides only in soils heavily infested with the nematodes. 相似文献
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Effects of pH and predation by Chaoborus larvae on the plankton of a shallow and acidic forest lake 总被引:1,自引:0,他引:1
1. Eutrophic acid lakes are not common. Delamere Lake in Cheshire, U.K. is shallow and acid (mean pH 4.5) with a very high phytoplankton crop (mean 290 μg chlorophyll a L?1), dominated by Dictyosphaerium pulchellum. Rotifers were dominant in the pelagic waters but small cladocerans (Alona guttata, Chydorus sphaericus and Scapholeberis mucronata) were occasional in the littoral waters. Chaoborus flavicans larvae were the top predators in this fishless lake. Two mesocosm experiments were carried out in which pH and Chaoborus populations were manipulated. 2. Progressively higher concentrations of D. pulchellum were maintained in the elevated pH treatments (pH 6 and 8; P < 0.001) with increased amounts of a Chlamydomonas species at the end of the experiment. Highest species richness was seen at ambient pH. Thus the low pH of Delamere Lake alone did not control the structure of the phytoplankton community. Keratella quadrata showed significantly higher abundance at pH 6 than in other pH treatments (P < 0.001). Species richness of rotifers was unaffected by pH. 3. Most Cladocera were C. sphaericus. Although never seen in the open lake, Daphnia pulex appeared in all the pH treatments. Low pH did not control small Cladocera abundance in Delamere Lake, but probably hampered reproduction in Daphnia. Negative correlations between chlorophyll a concentrations and Daphnia in the mesocosms (r2 = 0.215, P < 0.05), however, indicated the potential of large‐bodied daphniids in controlling phytoplankton. 4. Neither different combinations of Chaoborus instars (none, instars 1 and 2 and instars 3–5) nor different densities of instars 3–5 (0.15, 0.5 and 1.0 L?1) had a negative impact on Cladocera. Daphnia pulex remained unaffected in the experiment, perhaps because of its large size, and C. sphaericus because of its high reproductive rate compensating predatory losses. 5. Very low pH in Delamere Lake might suppress Daphnia by hampering its reproduction. Consequently, Daphnia may be vulnerable to invertebrate predation even at low predator density in the lake. 相似文献