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排序方式: 共有498条查询结果,搜索用时 296 毫秒
81.
Emanuela Frittoli Andrea Palamidessi Paola Marighetti Stefano Confalonieri Fabrizio Bianchi Chiara Malinverno Giovanni Mazzarol Giuseppe Viale Ines Martin-Padura Massimilliano Garré Dario Parazzoli Valentina Mattei Salvatore Cortellino Giovanni Bertalot Pier Paolo Di Fiore Giorgio Scita 《The Journal of cell biology》2014,206(2):307-328
The mechanisms by which tumor cells metastasize and the role of endocytic proteins in this process are not well understood. We report that overexpression of the GTPase RAB5A, a master regulator of endocytosis, is predictive of aggressive behavior and metastatic ability in human breast cancers. RAB5A is necessary and sufficient to promote local invasion and distant dissemination of various mammary and nonmammary tumor cell lines, and this prometastatic behavior is associated with increased intratumoral cell motility. Specifically, RAB5A is necessary for the formation of invadosomes, membrane protrusions specialized in extracellular matrix (ECM) degradation. RAB5A promotes RAB4- and RABENOSYN-5–dependent endo/exocytic cycles (EECs) of critical cargos (membrane-type 1 matrix metalloprotease [MT1-MMP] and β3 integrin) required for invadosome formation in response to motogenic stimuli. This trafficking circuitry is necessary for spatially localized hepatocyte growth factor (HGF)/MET signaling that drives invasive, proteolysis-dependent chemotaxis in vitro and for conversion of ductal carcinoma in situ to invasive ductal carcinoma in vivo. Thus, RAB5A/RAB4 EECs promote tumor dissemination by controlling a proteolytic, mesenchymal invasive program. 相似文献
82.
Novel Adeno‐Associated Viral Vector Delivering the Utrophin Gene Regulator Jazz Counteracts Dystrophic Pathology in mdx Mice 下载免费PDF全文
83.
Enrica Ciucci Pamela Calussi Ersilia Menesini Alessandra Mattei Martina Petralli Simone Orlandini 《International journal of biometeorology》2011,55(3):327-337
This study aimed to analyze the impact of winter weather conditions on young children’s behavior and affective states by examining
a group of 61 children attending day-care centers in Florence (Italy). Participants were 33 males, 28 females and their 11
teachers. The mean age of the children at the beginning of the observation period was 24.1 months. The day-care teachers observed
the children’s behavioral and emotional states during the morning before their sleeping time and filled in a questionnaire
for each baby five times over a winter period of 3 weeks. Air temperature, relative humidity, air pressure and solar radiation
data were collected every 15 min from a weather station located in the city center of Florence. At the same time, air temperature
and relative humidity data were collected in the classroom and in the garden of each day-care center. We used multilevel linear
models to evaluate the extent to which children’s emotional and behavioral states could be predicted by weather conditions,
controlling for child characteristics (gender and age). The data showed that relative humidity and solar radiation were the
main predictors of the children’s emotional and behavioral states. The outdoor humidity had a significant positive effect
on frustration, sadness and aggression; solar radiation had a significant negative effect only on sadness, suggesting that
a sunny winter day makes children more cheerful. The results are discussed in term of implications for parents and teachers
to improve children’s ecological environment. 相似文献
84.
Jean-Lou Justine Alain Lambert Xavier Mattei 《International journal for parasitology》1985,15(6):601-608
Justine J.-L., Lambert A. and Mattei X. 1985. Spermatozoon ultrastructure and phylogenetic relationships in the monogeneans (Platyhelminthes). International Journal for Parasitology15: 601–608. New observations reported in this study together with bibliographical data allow comparisons of spermatozoon ultrastructure in 28 genera of monogeneans, belonging to 19 families. The authors propose to compare and classify monogenean spermatozoa using two simple ultrastructural characteristics: (a) the number of axonemes, 1 or 2, (b) the presence or absence of cortical microtubules. These traits make it possible to group monogenean spermatozoa in four patterns. Pattern 1 (2 axonemes plus microtubules) is characteristic of the polyopisthocotyleans (9 families). The three other patterns are found in the monopisthocotyleans. Pattern 2 (2 axonemes without microtubules) is found in the Capsalidae and Dionchidae, which seem closely related, and also in the Udonellidae, Gyrodactylidae and Euzetrema. Pattern 3 (1 axoneme plus 1 altered axoneme plus microtubules) is found in the Monocotylidae and Loimoidae. Pattern 4 (1 axoneme without microtubules) is found in the Amphibdellatidae, Ancyrocephalidae, Calceostomatidae and Diplectanidae. A phylogeny of the monogeneans is drawn from the data of comparative spermatology; this scheme coincides in many points with the phylogeny of Lambert (1980) which was based on the study of chaetotaxy and ciliated cells of the oncomiracidium. 相似文献
85.
Gisele Grimber Colette Galand Michel Garbarz Marie-Genevieve Mattei Catherine Cavard Alain Zider Patrice Blanchet Pierre Boivin Pascale Briand Didier Dhermy 《Transgenic research》1992,1(6):268-274
In the process of generating transgenic mice, inserted foreign DNA can cause insertional inactivation of the flanking genetic
locus and simultaneously provide a molecular tag for localizing and cloning the inactivated gene. We describe the case of
an insertional mutation leading, in animals homozygous for the insertion, to severe anaemia that was lethal within a few days
after birth. The haemolytic anaemia and microspherocytosis of the red cells strongly suggested membrane abnormalities of the
erythrocytes. Byin situ localization of the integration site, protein analysis of the red cell membranes, northern and Southern blot analyses, we
were able to demonstrate that the integrated transgene had affected the α-spectrin gene locus. 相似文献
86.
P Collignon N Philip G Simonin J F Mattei F Giraud 《Genetic counseling (Geneva, Switzerland)》1992,3(4):221-222
We present a 5-year-old boy with developmental delay, severe microcephaly and preaxial polydactyly. These features are very similar to those previously described by Howard and Young (1) in their princeps report. 相似文献
87.
M Strambi R Mattei C De Felice P Borgogni 《Bollettino della Società italiana di biologia sperimentale》1992,68(4):271-275
Plasma lipids and apoprotein A and B levels were measured in 63 children, of both sexes, in the age range 11-14 years. The children have been subjected to a blood drawing after a 12 hour fast at least. Statistical analysis proves that total cholesterol (TC) is positively correlated with triglycerides (TG), HDL cholesterol (HDL) with apolipoproteins A (Apo A), apolipoproteins A (Apo A) with apoproteins B (Apo B). In the end we confirm the utility of determining plasma lipids and apoproteins to estimate lipidic risk for atherosclerosis in pediatric age. 相似文献
88.
89.
Che‐1 is targeted by c‐Myc to sustain proliferation in pre‐B‐cell acute lymphoblastic leukemia 下载免费PDF全文
Valentina Folgiero Matteo Pallocca Francesca De Nicola Frauke Goeman Valentina Bertaina Luisa Strocchio Paolo Romania Angela Pitisci Simona Iezzi Valeria Catena Tiziana Bruno Georgios Strimpakos Claudio Passananti Elisabetta Mattei Giovanni Blandino Maurizio Fanciulli 《EMBO reports》2018,19(3)
Despite progress in treating B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL), disease recurrence remains the main cause of treatment failure. New strategies to improve therapeutic outcomes are needed, particularly in high‐risk relapsed patients. Che‐1/AATF (Che‐1) is an RNA polymerase II‐binding protein involved in proliferation and tumor survival, but its role in hematological malignancies has not been clarified. Here, we show that Che‐1 is overexpressed in pediatric BCP‐ALL during disease onset and at relapse, and that its depletion inhibits the proliferation of BCP‐ALL cells. Furthermore, we report that c‐Myc regulates Che‐1 expression by direct binding to its promoter and describe a strict correlation between Che‐1 expression and c‐Myc expression. RNA‐seq analyses upon Che‐1 or c‐Myc depletion reveal a strong overlap of the respective controlled pathways. Genomewide ChIP‐seq experiments suggest that Che‐1 acts as a downstream effector of c‐Myc. These results identify the pivotal role of Che‐1 in the control of BCP‐ALL proliferation and present the protein as a possible therapeutic target in children with relapsed BCP‐ALL. 相似文献
90.